产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
BLIMP1/PRDM1抗体(3H2-E8)
目录 :
NB600-235
规格 :
0.1 ml (also 0.025 ml)
价格 :
349美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
3H2-E8
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 45
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 2b
Ye Y, Liu M, Tang L, Du F, Liu Y, Hao P, et al. Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis. Arthritis Res Ther. 2019;21:92 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s7a
Cao Y, Trillo Tinoco J, Sierra R, Anadon C, Dai W, Mohamed E, et al. ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression. Nat Commun. 2019;10:1280 pubmed 出版商
  • 流式细胞仪; 小鼠
  • 免疫印迹; 小鼠
Jang K, Mano H, Aoki K, Hayashi T, Muto A, Nambu Y, et al. Mitochondrial function provides instructive signals for activation-induced B-cell fates. Nat Commun. 2015;6:6750 pubmed 出版商
  • 免疫印迹; 人类
Rasul E, Salamon D, Nagy N, Leveau B, Banati F, Szenthe K, et al. The MEC1 and MEC2 lines represent two CLL subclones in different stages of progression towards prolymphocytic leukemia. PLoS ONE. 2014;9:e106008 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
  • 流式细胞仪; 小鼠
  • 免疫细胞化学; 小鼠
Kim J, Nakasaki M, Todorova D, Lake B, Yuan C, Jamora C, et al. p53 Induces skin aging by depleting Blimp1+ sebaceous gland cells. Cell Death Dis. 2014;5:e1141 pubmed 出版商
  • 免疫印迹; 人类
Horn M, Geisen C, Cermak L, Becker B, Nakamura S, Klein C, et al. DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation. Dev Cell. 2014;28:697-710 pubmed 出版商
  • 免疫印迹; 小鼠
Lin M, Yeh L, Chen S, Chiou H, Chu C, Yen L, et al. T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells. Clin Immunol. 2014;151:101-13 pubmed 出版商
  • 免疫印迹; 小鼠
Severa M, Islam S, Waggoner S, Jiang Z, Kim N, Ryan G, et al. The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8. J Immunol. 2014;192:2291-304 pubmed 出版商
  • 流式细胞仪; 小鼠
Kim E, Gasper D, Lee S, Plisch E, Svaren J, Suresh M. Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice. J Immunol. 2014;192:985-95 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Wong L, Brulois K, Toth Z, Inn K, Lee S, O Brien K, et al. The product of Kaposi's sarcoma-associated herpesvirus immediate early gene K4.2 regulates immunoglobulin secretion and calcium homeostasis by interacting with and inhibiting pERP1. J Virol. 2013;87:12069-79 pubmed 出版商
  • 免疫印迹; 人类
Parlato S, Bruni R, Fragapane P, Salerno D, Marcantonio C, Borghi P, et al. IFN-? regulates Blimp-1 expression via miR-23a and miR-125b in both monocytes-derived DC and pDC. PLoS ONE. 2013;8:e72833 pubmed 出版商
  • 免疫印迹; 小鼠
Lin M, Chou F, Yeh L, Fu S, Chiou H, Lin K, et al. B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes in NOD mice by suppressing Th1 and Th17 cells. Diabetologia. 2013;56:136-46 pubmed 出版商
  • 免疫印迹; 小鼠
Lee S, Rutan J, Monteith A, Jones S, Kang S, Krum K, et al. Receptor cross-talk spatially restricts p-ERK during TLR4 stimulation of autoreactive B cells. J Immunol. 2012;189:3859-68 pubmed 出版商
  • 免疫组化; 人类
Takata K, Sato Y, Nakamura N, Tokunaka M, Miki Y, Yukie Kikuti Y, et al. Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics. Mod Pathol. 2013;26:22-31 pubmed 出版商
  • 免疫沉淀; 人类
Morgan M, Mould A, Li L, Robertson E, Bikoff E. Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions. Mol Cell Biol. 2012;32:3403-13 pubmed 出版商
  • 免疫印迹; 人类
Ramon S, Gao F, Serhan C, Phipps R. Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells. J Immunol. 2012;189:1036-42 pubmed 出版商
  • 免疫印迹; 人类
Le Gallou S, Caron G, Delaloy C, Rossille D, Tarte K, Fest T. IL-2 requirement for human plasma cell generation: coupling differentiation and proliferation by enhancing MAPK-ERK signaling. J Immunol. 2012;189:161-73 pubmed 出版商
  • 流式细胞仪; 小鼠
Altin J, Goodnow C, Cook M. IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation. J Immunol. 2012;188:5478-88 pubmed 出版商
  • 免疫印迹; 人类
Nagy N, Adori M, Rasul A, Heuts F, Salamon D, Ujvári D, et al. Soluble factors produced by activated CD4+ T cells modulate EBV latency. Proc Natl Acad Sci U S A. 2012;109:1512-7 pubmed 出版商
  • 免疫沉淀; 小鼠
Shimshon L, Michaeli A, Hadar R, Nutt S, David Y, Navon A, et al. SUMOylation of Blimp-1 promotes its proteasomal degradation. FEBS Lett. 2011;585:2405-9 pubmed 出版商
  • 免疫细胞化学; 人类
Julaton V, Reijo Pera R. NANOS3 function in human germ cell development. Hum Mol Genet. 2011;20:2238-50 pubmed 出版商
  • 免疫组化-冰冻切片; 人类
  • 免疫组化-石蜡切片; 人类
Courts C, Montesinos Rongen M, Brunn A, Bug S, Siemer D, Hans V, et al. Recurrent inactivation of the PRDM1 gene in primary central nervous system lymphoma. J Neuropathol Exp Neurol. 2008;67:720-7 pubmed 出版商
  • 免疫细胞化学; 小鼠
Robertson E, Charatsi I, Joyner C, Koonce C, Morgan M, Islam A, et al. Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice. Development. 2007;134:4335-45 pubmed
  • 免疫印迹; 小鼠
John S, Clements J, Russell L, Garrett Sinha L. Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1. J Biol Chem. 2008;283:951-62 pubmed
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
Liu Y, Leboeuf C, Shi J, Li J, Wang L, Shen Y, et al. Rituximab plus CHOP (R-CHOP) overcomes PRDM1-associated resistance to chemotherapy in patients with diffuse large B-cell lymphoma. Blood. 2007;110:339-44 pubmed
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
Cattoretti G, Angelin Duclos C, Shaknovich R, Zhou H, Wang D, Alobeid B. PRDM1/Blimp-1 is expressed in human B-lymphocytes committed to the plasma cell lineage. J Pathol. 2005;206:76-86 pubmed
  • 免疫组化-石蜡切片; 小鼠
Chang D, Cattoretti G, Calame K. The dynamic expression pattern of B lymphocyte induced maturation protein-1 (Blimp-1) during mouse embryonic development. Mech Dev. 2002;117:305-9 pubmed
Wang Y, Wang C, Cai X, Mou C, Cui X, Zhang Y, et al. IL-21 Stimulates the expression and activation of cell cycle regulators and promotes cell proliferation in EBV-positive diffuse large B cell lymphoma. Sci Rep. 2020;10:12326 pubmed 出版商
Meer S, Perner Y, McAlpine E, Willem P. Extraoral plasmablastic lymphomas in a high human immunodeficiency virus endemic area. Histopathology. 2020;76:212-221 pubmed 出版商
Tian Y, Seumois G, De Oliveira Pinto L, Mateus J, Herrera de la Mata S, Kim C, et al. Molecular Signatures of Dengue Virus-Specific IL-10/IFN-γ Co-producing CD4 T Cells and Their Association with Dengue Disease. Cell Rep. 2019;29:4482-4495.e4 pubmed 出版商
Wu L, Ehlin Henriksson B, Zhou X, Zhu H, Ernberg I, Kis L, et al. Epstein-Barr virus (EBV) provides survival factors to EBV+ diffuse large B-cell lymphoma (DLBCL) lines and modulates cytokine induced specific chemotaxis in EBV+  DLBCL. Immunology. 2017;152:562-573 pubmed 出版商
McCarthy C, Kenny L. Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia. Sci Rep. 2016;6:32683 pubmed 出版商
Ramon S, Baker S, Sahler J, Kim N, Feldsott E, Serhan C, et al. The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant?. J Immunol. 2014;193:6031-40 pubmed 出版商
Gosal K, Dunlop K, Dhaliwal R, Ivanovska J, Kantores C, Desjardins J, et al. Rho kinase mediates right ventricular systolic dysfunction in rats with chronic neonatal pulmonary hypertension. Am J Respir Cell Mol Biol. 2015;52:717-27 pubmed 出版商
Joo H, Li D, Dullaers M, Kim T, Duluc D, Upchurch K, et al. C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses. Immunity. 2014;41:592-604 pubmed 出版商
Fan C, Lee L, Yu M, Tzen C, Chou C, Chang M. Upregulated hPuf-A promotes breast cancer tumorigenesis. Tumour Biol. 2013;34:2557-64 pubmed 出版商
Gao Y, Kazama H, Yonehara S. Bim regulates B-cell receptor-mediated apoptosis in the presence of CD40 signaling in CD40-pre-activated splenic B cells differentiating into plasma cells. Int Immunol. 2012;24:283-92 pubmed 出版商
Maseda D, Smith S, DiLillo D, Bryant J, Candando K, Weaver C, et al. Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo. J Immunol. 2012;188:1036-48 pubmed 出版商
Matsushita T, Tedder T. Identifying regulatory B cells (B10 cells) that produce IL-10 in mice. Methods Mol Biol. 2011;677:99-111 pubmed 出版商
Nishikawa K, Nakashima T, Hayashi M, Fukunaga T, Kato S, Kodama T, et al. Blimp1-mediated repression of negative regulators is required for osteoclast differentiation. Proc Natl Acad Sci U S A. 2010;107:3117-22 pubmed 出版商
Brzezinski J, Lamba D, Reh T. Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development. 2010;137:619-29 pubmed 出版商
Garcia Bates T, Baglole C, Bernard M, Murant T, Simpson Haidaris P, Phipps R. Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation. J Immunol. 2009;183:6903-12 pubmed 出版商
Wang X, Belguise K, O Neill C, Sánchez Morgan N, Romagnoli M, Eddy S, et al. RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1. Mol Cell Biol. 2009;29:3832-44 pubmed 出版商
Gong D, Malek T. Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production. J Immunol. 2007;178:242-52 pubmed
Severa M, Coccia E, Fitzgerald K. Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. J Biol Chem. 2006;281:26188-95 pubmed
图像
图像 1 :
Novus Biologicals NB600-235 图像 1
Western Blot: BLIMP1/PRDM1 Antibody (3H2-E8) [NB600-235] - The effect of IL-21 and CD40L exposure on MEC1 and MEC2 cells. Expression of EBNA-2 and LMP-1 in IL-21 treated cells. Expression of EBNA-2, LMP-1 and Blimp-1 by immunoblotting; positive control: CBM1-Ral-STO, negative control: Ramos. 1.5x105 cells were loaded in the control lanes and 5x105 were loaded in both untreated and IL-21 treated MEC1 and MEC2 lanes. Note low expression of EBNA-2 and high expression of LMP-1 after IL-21 treatment and induction of Blimp-1 after IL-21 treatment. Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.pone.0106008), licensed under a CC-BY licence.
产品信息
品牌 :
Novus
master code :
NB600-235
SKU号 :
NB600-235
产品名称 :
BLIMP1/PRDM1抗体(3H2-E8)
描述 :
The BLIMP1/PRDM1 Antibody (3H2-E8) from Novus is a mouse monoclonal antibody to BLIMP1/PRDM1. This antibody reacts with human, mouse, porcine. The BLIMP1/PRDM1 Antibody (3H2-E8) has been validated for the following applications: Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.
靶标 :
BLIMP1/PRDM1
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
3H2-E8
浓度 :
1毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
A fragment of mouse Blimp-1 corresponding to residues 199-409. [UniProt# Q60636]
抗体亚型 :
IgG1
纯度 :
蛋白质G纯化
物种 :
人类, 小鼠, 猪
基因符号 :
PRDM1
catalog number base :
NB600-235
应用 :
免疫印迹, 染色质免疫沉淀 , 流式细胞仪, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学/免疫荧光, 免疫沉淀, 免疫组化石蜡, 免疫组化冷冻
美元 :
349美元
别名 :
Beta-interferon gene positive regulatory domain I-binding factor, beta-interferon gene positive-regulatory domain I binding factor, BLIMP-1, BLIMP1MGC118925, blmp-1, B-lymphocyte-induced maturation protein 1, MGC118922, MGC118923, Positive regulatory domain I-binding factor 1, PR domain containing 1, with ZNF domain, PR domain zinc finger protein 1, PR domain-containing protein 1, PRDI-BF1MGC118924, PRDI-binding factor 1, PRDI-binding factor-1, PR-domain zinc finger protein 1
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。