产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
GLI-1抗体
目录 :
NB600-600
规格 :
0.1 ml (also 0.025 ml)
价格 :
349美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 狗
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片
更多信息或购买 :
Novus Biologicals 产品网页
文章摘录数: 24
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类
Jiang H, Li F, He C, Wang X, Li Q, Gao H. Expression of Gli1 and Wnt2B correlates with progression and clinical outcome of pancreatic cancer. Int J Clin Exp Pathol. 2014;7:4531-8 pubmed
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Nye M, Almada L, Fernández Barrena M, Marks D, Elsawa S, Vrabel A, et al. The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor ?-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner. J Biol Chem. 2014;289:15495-506 pubmed 出版商
  • 免疫印迹; 人类
Huang L, Walter V, Hayes D, Onaitis M. Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer. Clin Cancer Res. 2014;20:1566-75 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Mazumdar T, Sandhu R, Qadan M, DeVecchio J, Magloire V, Agyeman A, et al. Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells. PLoS ONE. 2013;8:e75253 pubmed 出版商
  • 免疫印迹; 小鼠
Regard J, Malhotra D, Gvozdenovic Jeremic J, Josey M, Chen M, Weinstein L, et al. Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med. 2013;19:1505-12 pubmed 出版商
  • 免疫组化; 人类
Karlou M, Lu J, Wu G, Maity S, Tzelepi V, Navone N, et al. Hedgehog signaling inhibition by the small molecule smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b. Prostate. 2012;72:1638-47 pubmed 出版商
  • 免疫组化; 人类
Tzelepi V, Karlou M, Wen S, Hoang A, Logothetis C, Troncoso P, et al. Expression of hedgehog pathway components in prostate carcinoma microenvironment: shifting the balance towards autocrine signalling. Histopathology. 2011;58:1037-47 pubmed 出版商
  • 免疫印迹; 人类
Mazumdar T, DeVecchio J, Shi T, Jones J, Agyeman A, Houghton J. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011;71:1092-102 pubmed 出版商
Mazzone A, Gibbons S, Eisenman S, Strege P, Zheng T, D Amato M, et al. Direct repression of anoctamin 1 (ANO1) gene transcription by Gli proteins. FASEB J. 2019;33:6632-6642 pubmed 出版商
Wang K, Chen D, Qian Z, Cui D, Gao L, Lou M. Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma. Cancer Cell Int. 2017;17:117 pubmed 出版商
Tanno B, Leonardi S, Babini G, Giardullo P, De Stefano I, Pasquali E, et al. Nanog-driven cell-reprogramming and self-renewal maintenance in Ptch1 +/- granule cell precursors after radiation injury. Sci Rep. 2017;7:14238 pubmed 出版商
Wei R, Lv M, Li F, Cheng T, Zhang Z, Jiang G, et al. Human CAFs promote lymphangiogenesis in ovarian cancer via the Hh-VEGF-C signaling axis. Oncotarget. 2017;8:67315-67328 pubmed 出版商
Schneider R, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, van Strien P, et al. Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target. Cell Stem Cell. 2017;20:785-800.e8 pubmed 出版商
Xu T, Zhang H, Park S, Venneti S, Kuick R, Ha K, et al. Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis. Neoplasia. 2017;19:216-225 pubmed 出版商
Puri P, Bushnell D, Schaefer C, Bates C. Six2creFrs2? knockout mice are a novel model of renal cystogenesis. Sci Rep. 2016;6:36736 pubmed 出版商
Wu M, Ingram L, Tolosa E, Vera R, Li Q, Kim S, et al. Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. J Biol Chem. 2016;291:25749-25760 pubmed
Vidal M, Lourenço S, Soares F, Gurgel C, Studart E, Valverde L, et al. The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration. Tumour Biol. 2016;37:9587-601 pubmed 出版商
Valverde L, Pereira T, Dias R, Guimarães V, Ramos E, Santos J, et al. Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation. Tumour Biol. 2016;37:9233-41 pubmed 出版商
Comba A, Almada L, Tolosa E, Iguchi E, Marks D, Vara Messler M, et al. Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid. J Biol Chem. 2016;291:1933-47 pubmed 出版商
Yeddula N, Xia Y, Ke E, Beumer J, Verma I. Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinoma. Proc Natl Acad Sci U S A. 2015;112:E6476-85 pubmed 出版商
Jackson D, Smith T, Amarsaikhan N, Han W, Neil M, Boi S, et al. Modulation of the IL-6 Receptor α Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells. J Immunol. 2015;195:2908-16 pubmed 出版商
Mazumdar T, DeVecchio J, Agyeman A, Shi T, Houghton J. Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. Cancer Res. 2011;71:5904-14 pubmed 出版商
Qualtrough D, Buda A, Gaffield W, Williams A, Paraskeva C. Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment. Int J Cancer. 2004;110:831-7 pubmed
Niemann C, Unden A, Lyle S, Zouboulis C, Toftgard R, Watt F. Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. Proc Natl Acad Sci U S A. 2003;100 Suppl 1:11873-80 pubmed
产品信息
SKU号 :
NB600-600
产品名称 :
GLI-1抗体
单位尺寸 :
0.1 ml (also 0.025 ml)
描述 :
The GLI-1 Antibody from Novus is a rabbit polyclonal antibody to GLI-1. This antibody reacts with human, mouse, canine. The GLI-1 Antibody has been validated for the following applications: Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoblotting, Flow (Intracellular).
靶标 :
GLI-1
类别 :
一抗
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1毫克/毫升
共轭标签 :
未共轭
宿主 :
兔
免疫原 :
A synthetic peptide made toward the C-terminus portion of the human GLI-1 protein (between residues 800-850) [Uniprot: P08151]
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 狗
特异性 :
This is directed against Gli1 from mouse brain
基因符号 :
GLI1
catalog number base :
NB600-600
accessionNumbers :
P08151
应用 :
Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoblotting, Flow (Intracellular)
2020 Proposedprice USD :
349美元
别名 :
GLI family zinc finger 1, Glioma-associated oncogene, glioma-associated oncogene family zinc finger 1, glioma-associated oncogene homolog 1 (zinc finger protein), GLIzinc finger protein GLI1, Oncogene GLI
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
Novus Biologicals 产品网页
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工，Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外，Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂，Novus Biologicals扮演市场上重要的角色。