产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
RPA2[p Ser4, p Ser8]抗体
目录 :
NBP1-23017
规格 :
100微升
价格 :
499美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
H1beta234
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 106
出版应用/物种/样本/稀释 | 参考文献 |
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Taylor S, Bagnall J, Mason D, Levy R, Fernig D, See V. Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility. Open Biol. 2016;6: pubmed
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Xiang L, Gilkes D, Hu H, Luo W, Bullen J, Liang H, et al. HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells. Oncotarget. 2015;6:11768-78 pubmed
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Xiang L, Gilkes D, Hu H, Takano N, Luo W, Lu H, et al. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget. 2014;5:12509-27 pubmed
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Hu H, Takano N, Xiang L, Gilkes D, Luo W, Semenza G. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 2014;5:8853-68 pubmed
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Puppo M, Battaglia F, Ottaviano C, Delfino S, Ribatti D, Varesio L, et al. Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha. Mol Cancer Ther. 2008;7:1974-84 pubmed 出版商
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Engebretsen B, Irwin D, Valdez M, O Donovan M, Tucker A, van Patot M. Acute hypobaric hypoxia (5486 m) induces greater pulmonary HIF-1 activation in hilltop compared to madison rats. High Alt Med Biol. 2007;8:312-21 pubmed
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Baek J, Liu Y, McDonald K, Wesley J, Zhang H, Semenza G. Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. J Biol Chem. 2007;282:33358-66 pubmed
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Cheng G, Shao Z, Chaudhari B, Agrawal D. Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007;293:L1339-47 pubmed
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Hu C, Sataur A, Wang L, Chen H, Simon M. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell. 2007;18:4528-42 pubmed
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Baek J, Liu Y, McDonald K, Wesley J, Hubbi M, Byun H, et al. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. J Biol Chem. 2007;282:23572-80 pubmed
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Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller K, et al. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell. 2007;11:407-20 pubmed
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Shimojo N, Jesmin S, Zaedi S, Otsuki T, Maeda S, Yamaguchi N, et al. Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol. 2007;293:H474-81 pubmed
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Asikainen T, Chang L, Coalson J, Schneider B, Waleh N, Ikegami M, et al. Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB J. 2006;20:1698-700 pubmed
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Slomiany M, Rosenzweig S. Hypoxia-inducible factor-1-dependent and -independent regulation of insulin-like growth factor-1-stimulated vascular endothelial growth factor secretion. J Pharmacol Exp Ther. 2006;318:666-75 pubmed
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Nakamura K, Martin K, Jackson J, Beppu K, Woo C, Thiele C. Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells. Cancer Res. 2006;66:4249-55 pubmed
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Hu C, Iyer S, Sataur A, Covello K, Chodosh L, Simon M. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol. 2006;26:3514-26 pubmed
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Okuyama H, Krishnamachary B, Zhou Y, Nagasawa H, Bosch Marce M, Semenza G. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. J Biol Chem. 2006;281:15554-63 pubmed
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Hui A, Bauer A, Striet J, Schnell P, Czyzyk Krzeska M. Calcium signaling stimulates translation of HIF-alpha during hypoxia. FASEB J. 2006;20:466-75 pubmed
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Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, et al. Activation of hypoxia-inducible factor 1 during macrophage differentiation. Am J Physiol Cell Physiol. 2006;291:C104-13 pubmed
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Amir S, Wang R, Matzkin H, Simons J, Mabjeesh N. MSF-A interacts with hypoxia-inducible factor-1alpha and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis. Cancer Res. 2006;66:856-66 pubmed
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Schultz K, Fanburg B, Beasley D. Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2006;290:H2528-34 pubmed
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Hirota K, Fukuda R, Takabuchi S, Kizaka Kondoh S, Adachi T, Fukuda K, et al. Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling. J Biol Chem. 2004;279:41521-8 pubmed
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Slomiany M, Rosenzweig S. IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1 alpha expression and activity in retinal pigment epithelial cell line D407. Invest Ophthalmol Vis Sci. 2004;45:2838-47 pubmed
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Arsham A, Plas D, Thompson C, Simon M. Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer Res. 2004;64:3500-7 pubmed
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Slomiany M, Rosenzweig S. Autocrine effects of IGF-I-induced VEGF and IGFBP-3 secretion in retinal pigment epithelial cell line ARPE-19. Am J Physiol Cell Physiol. 2004;287:C746-53 pubmed
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Tissot van Patot M, Bendrick Peart J, Beckey V, Serkova N, Zwerdlinger L. Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004;287:L525-32 pubmed
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Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker R, Melillo G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res. 2004;64:1475-82 pubmed
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Alam H, Maizels E, Park Y, Ghaey S, Feiger Z, Chandel N, et al. Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of f. J Biol Chem. 2004;279:19431-40 pubmed
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Hu C, Wang L, Chodosh L, Keith B, Simon M. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol. 2003;23:9361-74 pubmed
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Fukuda R, Kelly B, Semenza G. Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Res. 2003;63:2330-4 pubmed
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Mabjeesh N, Escuin D, LaVallee T, Pribluda V, Swartz G, Johnson M, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell. 2003;3:363-75 pubmed
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Mabjeesh N, Willard M, Harris W, Sun H, Wang R, Zhong H, et al. Dibenzoylmethane, a natural dietary compound, induces HIF-1 alpha and increases expression of VEGF. Biochem Biophys Res Commun. 2003;303:279-86 pubmed
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Elvert G, Kappel A, Heidenreich R, Englmeier U, Lanz S, Acker T, et al. Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1). J Biol Chem. 2003;278:7520-30 pubmed
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Volm M, Koomagi R, Mattern J, Efferth T. Protein expression profiles indicative for drug resistance of non-small cell lung cancer. Br J Cancer. 2002;87:251-7 pubmed
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Rapisarda A, Uranchimeg B, Scudiero D, Selby M, Sausville E, Shoemaker R, et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res. 2002;62:4316-24 pubmed
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Fukuda R, Hirota K, Fan F, Jung Y, Ellis L, Semenza G. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem. 2002;277:38205-11 pubmed
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Bernaudin M, Tang Y, Reilly M, Petit E, Sharp F. Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J Biol Chem. 2002;277:39728-38 pubmed
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Mabjeesh N, Post D, Willard M, Kaur B, Van Meir E, Simons J, et al. Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res. 2002;62:2478-82 pubmed
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Zhong H, Hanrahan C, van der Poel H, Simons J. Hypoxia-inducible factor 1alpha and 1beta proteins share common signaling pathways in human prostate cancer cells. Biochem Biophys Res Commun. 2001;284:352-6 pubmed
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Tendler D, Bao C, Wang T, Huang E, Ratovitski E, Pardoll D, et al. Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis. Cancer Res. 2001;61:3682-8 pubmed
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Zagzag D, Zhong H, Scalzitti J, Laughner E, Simons J, Semenza G. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 2000;88:2606-18 pubmed
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产品信息
品牌 :
Novus
MasterCode :
NBP1-23017
SKU号 :
NBP1-23017
产品名称 :
RPA2[p Ser4, p Ser8]抗体
描述 :
The RPA2 [p Ser4, p Ser8] Antibody from NBP1-23017 is a nbp1-23017 antibody to . This antibody reacts with phospho specific. The RPA2 [p Ser4, p Ser8] Antibody has been validated for the following applications: NP_002937.1.
靶标 :
RPA2
类别 :
一抗
单位尺寸 :
100微升
缓冲液 :
三羟甲基氨基甲烷柠檬酸盐/磷酸盐(pH值7.0-8.0)
克隆性 :
多克隆
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
兔
免疫原 :
Immunogen was a dually phosphorylated synthetic peptide, which represented a portion of human replication protein A2, 32 kDa surrounding phosphorylated serines that corresponded to positions 4 and 8 using the numbering given in entry NP_002937.1 (GeneID
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠
基因符号 :
RPA2
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/RPA2-[p-Ser4--p-Ser8]-Antibody-Western-Blot-NBP1-23017-img0047.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/RPA2-[p-Ser4--p-Ser8]-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-23017-img0046.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/RPA2-[p-Ser4--p-Ser8]-Antibody-Immunohistochemistry-Paraffin-NBP1-23017-img0050.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/RPA2-[p-Ser4--p-Ser8]-Antibody-Western-Blot-NBP1-23017-img0003.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/RPA2-[p-Ser4--p-Ser8]-Antibody-Western-Blot-NBP1-23017-img0042.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/RPA2-[p-Ser4--p-Ser8]-Antibody-Immunohistochemistry-Paraffin-NBP1-23017-img0049.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/RPA2-[p-Ser4--p-Ser8]-Antibody-Immunoprecipitation-NBP1-23017-img0048.jpg
accessionNumbers :
NP_002937.1
应用 :
Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Knockdown Validated
美元 :
499美元
别名 :
REPA2, Replication factor A protein 2, replication protein A 32 kDa subunit, Replication protein A 34 kDa subunit, replication protein A2 (32kD), replication protein A2, 32kDa, RF-A protein 2, RP-A p32, RP-A p34, RPA32, RPA34
储存 :
存放在4C。 不冻结
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。