IKK甲抗体(14A231)-无叠氮物 | Novus Biologicals NBP2-27409 产品信息

产品简要

公司名称 :

Novus Biologicals

其他品牌 :

IMGENEX

产品类型 :

抗体

产品名称 :

IKK甲抗体(14A231)-无叠氮物

NBP2-27409

规格 :

0.1毫克

价格 :

449美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

14A231

反应物种 :

人类, 小鼠, 大鼠

应用 :

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片

更多信息或购买 :

Novus Biologicals 产品网页

文章摘录数: 41

参考文献
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle N, et al. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017;32:824-839.e8 pubmed 出版商
Cui J, Li Y, Zhu L, Liu D, Songyang Z, Wang H, et al. NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4. Nat Immunol. 2012;13:387-95 pubmed 出版商
Bakkar N, Ladner K, Canan B, Liyanarachchi S, Bal N, Pant M, et al. IKK? and alternative NF-?B regulate PGC-1? to promote oxidative muscle metabolism. J Cell Biol. 2012;196:497-511 pubmed 出版商
Delhase M, Kim S, Lee H, Naiki Ito A, Chen Y, Ahn E, et al. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012;109:E177-86 pubmed 出版商
Harikumar K, Sung B, Pandey M, Guha S, Krishnan S, Aggarwal B. Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. Mol Pharmacol. 2010;77:818-27 pubmed 出版商
Huang J, Ren T, Guan H, Jiang Y, Cheng H. HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB. J Biol Chem. 2009;284:6208-17 pubmed 出版商
Eckmann L, Nebelsiek T, Fingerle A, Dann S, Mages J, Lang R, et al. Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A. 2008;105:15058-63 pubmed 出版商
Otipoby K, Sasaki Y, Schmidt Supprian M, Patke A, Gareus R, Pasparakis M, et al. BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells. Proc Natl Acad Sci U S A. 2008;105:12435-8 pubmed 出版商
Pandey M, Sung B, Kunnumakkara A, Sethi G, Chaturvedi M, Aggarwal B. Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis. Cancer Res. 2008;68:5370-9 pubmed 出版商
Kasinski A, Du Y, Thomas S, Zhao J, Sun S, Khuri F, et al. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Mol Pharmacol. 2008;74:654-61 pubmed 出版商
Beraza N, Ludde T, Assmus U, Roskams T, Vander Borght S, Trautwein C. Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury. Gastroenterology. 2007;132:2504-17 pubmed
Jackson Bernitsas D, Ichikawa H, Takada Y, Myers J, Lin X, Darnay B, et al. Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma. Oncogene. 2007;26:1385-97 pubmed
Sethi G, Ahn K, Sandur S, Lin X, Chaturvedi M, Aggarwal B. Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway. J Biol Chem. 2006;281:23425-35 pubmed
Ichikawa H, Aggarwal B. Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation. Clin Cancer Res. 2006;12:662-8 pubmed
Vinolo E, Sebban H, Chaffotte A, Israel A, Courtois G, Veron M, et al. A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation. J Biol Chem. 2006;281:6334-48 pubmed
Ichikawa H, Takada Y, Murakami A, Aggarwal B. Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. J Immunol. 2005;174:7383-92 pubmed
Ruocco M, Maeda S, Park J, Lawrence T, Hsu L, Cao Y, et al. I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med. 2005;201:1677-87 pubmed
Nonaka M, Horie R, Itoh K, Watanabe T, Yamamoto N, Yamaoka S. Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts. Oncogene. 2005;24:3976-86 pubmed
Panopoulos A, Harraz M, Engelhardt J, Zandi E. Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem. 2005;280:2912-23 pubmed
Shishodia S, Aggarwal B. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem. 2004;279:47148-58 pubmed
Shishodia S, Koul D, Aggarwal B. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. J Immunol. 2004;173:2011-22 pubmed
Takada Y, Fang X, Jamaluddin M, Boyd D, Aggarwal B. Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J Biol Chem. 2004;279:39541-54 pubmed
Chandrasekar B, Vemula K, Surabhi R, Li Weber M, Owen Schaub L, Jensen L, et al. Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death. J Biol Chem. 2004;279:20221-33 pubmed
Takada Y, Singh S, Aggarwal B. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem. 2004;279:15096-104 pubmed
Takada Y, Aggarwal B. Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J Biol Chem. 2004;279:4750-9 pubmed
Saito N, Courtois G, Chiba A, Yamamoto N, Nitta T, Hironaka N, et al. Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines. J Biol Chem. 2003;278:46565-75 pubmed
Chen L, Egan L, Li Z, Greten F, Kagnoff M, Karin M. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med. 2003;9:575-81 pubmed
Majumdar S, Aggarwal B. Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types. Oncogene. 2003;22:1206-18 pubmed
Ashikawa K, Majumdar S, Banerjee S, Bharti A, Shishodia S, Aggarwal B. Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. J Immunol. 2002;169:6490-7 pubmed
Chinanonwait N, Miura H, Yamamoto N, Yamaoka S. A recessive mutant cell line with a constitutive IkappaB kinase activity. FEBS Lett. 2002;531:553-60 pubmed
Dejardin E, Droin N, Delhase M, Haas E, Cao Y, Makris C, et al. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity. 2002;17:525-35 pubmed
Makris C, Roberts J, Karin M. The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation. Mol Cell Biol. 2002;22:6573-81 pubmed
Anto R, Mukhopadhyay A, Shishodia S, Gairola C, Aggarwal B. Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. Carcinogenesis. 2002;23:1511-8 pubmed
Majumdar S, Lamothe B, Aggarwal B. Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester. J Immunol. 2002;168:2644-51 pubmed
Agou F, Ye F, Goffinont S, Courtois G, Yamaoka S, Israel A, et al. NEMO trimerizes through its coiled-coil C-terminal domain. J Biol Chem. 2002;277:17464-75 pubmed
Cao Y, Bonizzi G, Seagroves T, Greten F, Johnson R, Schmidt E, et al. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 2001;107:763-75 pubmed
Majumdar S, Aggarwal B. Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation. J Immunol. 2001;167:2911-20 pubmed
Miller B, Zandi E. Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation. J Biol Chem. 2001;276:36320-6 pubmed
Koul D, Yao Y, Abbruzzese J, Yung W, Reddy S. Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway. J Biol Chem. 2001;276:11402-8 pubmed
Manna S, Mukhopadhyay A, Aggarwal B. Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. J Immunol. 2000;165:5962-9 pubmed
Manna S, Mukhopadhyay A, Aggarwal B. IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis. J Immunol. 2000;165:4927-34 pubmed

图像

图像 1 :

Western Blot: IKK alpha Antibody (14A231) - Azide Free [NBP2-27409] - Total protein from various Human, Mouse and Rat cell lines were separated on a 12% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 1.0 ug/mL anti-IKK-alpha in 1% non-fat milk in TBST and detected with an anti-mouse HRP secondary antibody using chemiluminescence. Image using the BSA free format of this product.

产品信息

品牌 :

Novus Biologicals, a Bio-Techne Brand

catalog number base :

NBP2-27409

SKU号 :

NBP2-27409

产品名称 :

IKK甲抗体(14A231)-无叠氮物

描述 :

The IKK alpha Antibody (14A231) - Azide Free from Novus is a mouse monoclonal antibody to IKK alpha. This antibody reacts with human, mouse, rat, primate. The IKK alpha Antibody (14A231) - Azide Free has been validated for the following applications: Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), CyTOF-ready.

靶标 :

IKK甲

类别 :

一抗

单位尺寸 :

0.1毫克

缓冲液 :

PBS

克隆性 :

单克隆

克隆 :

14A231

浓度 :

1.0毫克/毫升

共轭标签 :

未共轭

宿主 :

小鼠

免疫原 :

这通过免疫制备抗体a多聚组氨酸标签全长人类IKK甲蛋白

抗体亚型 :

IgG1 Kappa

纯度 :

蛋白质G纯化

物种 :

人类, 小鼠, 大鼠, 灵长类动物

基因符号 :

CHUK

应用 :

Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), CyTOF-ready

美元 :

449美元

别名 :

conserved helix-loop-helix ubiquitous kinaseIKBKA, EC 2.7.11, EC 2.7.11.10, IkappaB kinase, I-kappa-B kinase 1, I-kappa-B kinase alpha, IkBKA, IKK1I-kappa-B kinase-alpha, IKK-A, IKKAIkB kinase alpha subunit, IKK-alphainhibitor of nuclear factor kappa-B kinase subunit alpha, NFKBIKAIKK-a kinase, Nuclear factor NFkappaB inhibitor kinase alpha, Nuclear factor NF-kappa-B inhibitor kinase alpha, TCF16, TCF-16, Transcription factor 16

储存 :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

更多信息或购买 :

Novus Biologicals 产品网页

公司信息

Novus Biologicals

10771 E Easter Ave
Centennial, CO 80112

technical@novusbio.com

https://www.novusbio.com

1-888-506-6887 303-730-1950

公司总部: 美国

Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工，Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外，Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂，Novus Biologicals扮演市场上重要的角色。