产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
表皮生长因子受体抗体(DH8.3)- EGFRvIII, 突变体
目录 :
NBP2-50599
规格 :
0.1 ml (also 0.025 ml)
价格 :
299美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
DH8.3
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫沉淀, 流式细胞仪
更多信息或购买 :
文章摘录数: 7
参考文献
Banisadr A, Eick M, Beri P, Parisian A, Yeoman B, Placone J, et al. EGFRvIII uses intrinsic and extrinsic mechanisms to reduce glioma adhesion and increase migration. J Cell Sci. 2020;133: pubmed 出版商
Plichta Z, Horak D, Marekova D, Turnovcova K, Kaiser R, Jendelova P. Poly[N-(2-hydroxypropyl)methacrylamide]-Modified Magnetic γ-F2 O3 Nanoparticles Conjugated with Doxorubicin for Glioblastoma Treatment. ChemMedChem. 2020;15:96-104 pubmed 出版商
Brown C, Amante J, Chhoy P, Elaimy A, Liu H, Zhu L, et al. Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export. Dev Cell. 2019;51:575-586.e4 pubmed 出版商
Trujillo Alonso V, Pratt E, Zong H, Lara Martinez A, Kaittanis C, Rabie M, et al. FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels. Nat Nanotechnol. 2019;14:616-622 pubmed 出版商
Nishikawa R, Sugiyama T, Narita Y, Furnari F, Cavenee W, Matsutani M. Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma. Brain Tumor Pathol. 2004;21:53-6 pubmed
Jungbluth A, Stockert E, Huang H, Collins V, Coplan K, Iversen K, et al. A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor. Proc Natl Acad Sci U S A. 2003;100:639-44 pubmed
Johns T, Stockert E, Ritter G, Jungbluth A, Huang H, Cavenee W, et al. Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene. Int J Cancer. 2002;98:398-408 pubmed
图像
图像 1 :
Novus Biologicals NBP2-50599 图像 1
Flow Cytometry: EGFR Antibody (DH8.3) - EGFRvIII [NBP2-50599] - An intracellular stain was performed on A431 cells with EGFR [DH8.3] Antibody NBP2-50599R (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to DyLight 550.
产品信息
品牌 :
Novus
MasterCode :
NBP2-50599
SKU号 :
NBP2-50599
产品名称 :
表皮生长因子受体抗体(DH8.3)- EGFRvIII, 突变体
单位尺寸 :
0.1 ml (also 0.025 ml)
描述 :
The EGFR Antibody (DH8.3) - EGFRvIII, Mutant from Novus is a mouse monoclonal antibody to EGFR. This antibody reacts with human. The EGFR Antibody (DH8.3) - EGFRvIII, Mutant has been validated for the following applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunoprecipitation, CyTOF-ready.
靶标 :
表皮生长因子受体
类别 :
一抗
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
DH8.3
浓度 :
1毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
Synthetic peptide corresponding to the junctional region of the truncated receptor LEEKKGNYVVTDHC,conjugated to keyhole limpet haemcyanin.
抗体亚型 :
IgG1
纯度 :
蛋白质G纯化
物种 :
人类
特异性 :
Clone DH8.3 of EGF R/ErbB1 antibody is specific for Truncated EGFR which is also called EGFR type III, EGFRvIII or delta-EGFR (characterised by a deletion of 267 amino acids in the extracellular domain, leading to a receptor which is unable to bind ligand yet is constitutively active). Because of its impaired internalisation and degradation, EGFRvIII is known to enhance tumourigenesis. NOTE: Clone DH8.3 DOES NOT cross-react with full length or wildtype EGFR (wtEGFR).
基因符号 :
表皮生长因子受体
accessionNumbers :
Q01279
应用 :
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunoprecipitation, CyTOF-ready
美元 :
299美元
别名 :
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EC 2.7.10, EC 2.7.10.1, EGFR variant III, epidermal growth factor receptor, epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b)oncogene homolog), ERBB, ErbB1, ERBB1PIG61, HER1, mENA, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。