抗体

小鼠单克隆抗体BCL-10

20003

100µl

264.00美元

单克隆

小鼠

nonconjugated

4F8

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪

小鼠单克隆抗体BCL-10

人类;小鼠

4F8;

小鼠IgG1

100µl

4?;-20?为长期储存

Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

纯化重组片段对应于人BCL-10在大肠杆菌中表达

纯化抗体在PBS含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000;ICC: 1/200 - 1/1000;FCM: 1/200 - 1/400

1. Willis, T.G., et al. (1999) Cell. 96, 35-45. ; 2. Lucas, P.C., et al. (2001) J. Biol.Chem. 276, 19012-19019. ; 3. Wang, L., et al. (2001) J. Biol.Chem. 276, 21405-21409 ;

264.00美元

单克隆抗体

26kDa

CLAP;Me10;CIPER;c-E10;CARMEN