抗体

小鼠单克隆抗体肿瘤坏死因子甲

20161

100µl

308.00美元

单克隆

小鼠

nonconjugated

2A9B9

免疫印迹, 酶联免疫吸附测定

小鼠单克隆抗体肿瘤坏死因子甲

人类

2A9B9;

小鼠IgG1

100µl

4?;-20?为长期储存

TNF-alpha (tumor necrosis factor alpha) is an important cytokine produced by numerous cell types including neutrophils, activated lymphocytes, macrophages and NK cells. It plays a critical role in inflammatory responses and in apoptosis. TNF-alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF-alpha exists as a multimer of two, three, or five non covalently linked units, but shows a single 17 kDa band following SDS PAGE under non reducing conditions. Although it has little effect on many cultured normal human cells, TNF-alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF-alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF-alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

Recombinant Human TNF-alpha (BioSource company, Cat.No. PHC3013)

纯化抗体在PBS含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000

1. Knowlton KU. Yajima T. J Am Coll Cardiol. 2004,Sep 15, 44(6):1298-300. ; 2. Reynolds JL. Ignatowski TA. Gallant S.et al. Brain Res. 2004,Oct 8, 1023(1):112-20. ; 3. Dulak J. Tomala K. Loboda A. et al. Life Sci. 2004,Oct 8, 75(21):2573-86. ;

308.00美元

单克隆抗体

DIF;TNFA;TNFSF2;肿瘤坏死因子甲