抗体

小鼠单克隆抗体SORL1

20164

100µl

352.00美元

单克隆

小鼠

nonconjugated

7D7B11

免疫印迹, 酶联免疫吸附测定

小鼠单克隆抗体SORL1

人类

7D7B11;

小鼠IgG1

100µl

4?;-20?为长期储存

SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

Purified recombinant fragment of SORL1 (aa2159-2214) expressed in E. Coli.

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000

1. Scherzer CR. Offe K. Gearing M. et al. Arch Neurol. 2004, Aug, 61(8):1200-5. ; 2. Gabrielsson BG. Olofsson LE. Sjogren A. et al. Obes Res. 2005, Apr, 13(4):649-52. ; 3. Shah S. Yu G. Mol Interv. 2006, Apr, 6(2):74-6, 58. Review.

352.00美元

单克隆抗体

SORL1