抗体

小鼠单克隆抗体RET

20169

100µl

308.00美元

单克隆

小鼠

nonconjugated

6E4C4

免疫印迹, 酶联免疫吸附测定

小鼠单克隆抗体RET

人类

6E4C4;

小鼠IgG1

100µl

4?;-20?为长期储存

RET (ret proto-oncogene) is a member of the cadherin superfamily and a receptor tyrosine kinase, which are cell-surface molecules that transduce signals for cell growth and differentiation. It can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.

Purified recombinant fragment of RET (aa896-1063) expressed in E. Coli. ;

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000

1. Young HM. Anderson RB. Anderson CR. Auton Neurosci. 2004, May 31,112(1-2):1-14. ; 2. Myers SM. Mulligan LM. Cancer Res. 2004, Jul 1,64(13):4453-63.

308.00美元

单克隆抗体

RET