抗体

小鼠单克隆抗体v-erb-b2成红细胞白血病病毒致瘤基因2

20209

100μl

352.00美元

单克隆

小鼠

nonconjugated

6C2B12

免疫印迹, 酶联免疫吸附测定, 免疫组化

小鼠单克隆抗体v-erb-b2成红细胞白血病病毒致瘤基因2

人类

6C2B12;

小鼠IgG1/小鼠IgG2b

100μl

4℃;-20℃为长期储存

ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian). This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized

纯化重组片段对应于人v-erb-b2成红细胞白血病病毒致瘤基因2(aa750-987)在大肠杆菌中表达。;

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000

1. RR Mehta, JH McDermott, TJ Hieken, et al. J. Clin. Oncol. 1998;16:2409 - 2416. ; 2. Hideko Y, Vered S, and Daniel F.H, et al. J. Clin. Oncol.2001;19:2334 - 2356. ; 3. Magali F, Kamel H, C閏ile B, et al. Clinical Cancer Research. 2000;6:4745-4754. ;

352.00美元

单克隆抗体

NEU;HER2;TKR1;CD340;HER-2