抗体

小鼠单克隆抗体DDR1

20242

100μl

264.00美元

单克隆

小鼠

nonconjugated

2G4E12

免疫印迹, 酶联免疫吸附测定

小鼠单克隆抗体DDR1

人类

2G4E12;

小鼠IgG1

100μl

4℃;-20℃为长期储存

DDR1: discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

Purified recombinant fragment of DDR1 (aa602-681) expressed in E. Coli. ;

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000

1. FASEB J. 2000 May;14(7):973-81. ; 2. Exp Eye Res. 2001 Jan;72(1):87-92. ; 3. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903.

264.00美元

单克隆抗体

CAK;DDR;NEP;PTK3;RTK6;TRKE;CD167