抗体

小鼠单克隆抗体ABL1

20244

100μl

308.00美元

单克隆

小鼠

nonconjugated

7B11D6

免疫印迹, 酶联免疫吸附测定

小鼠单克隆抗体ABL1

人类

7B11D6;

小鼠IgG1

100μl

4℃;-20℃为长期储存

ABL1: c-abl oncogene 1, receptor tyrosine kinase. The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

Purified recombinant fragment of ABL1 (aa577-650) expressed in E. Coli.

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000

1. Cell. 2006 Nov 3;127(3):635-48. ; 2. Biochem Biophys Res Commun. 2007 Jan 12;352(2):431-6.

308.00美元

单克隆抗体

ABL; JTK7; p150; c-ABL; v-abl