抗体

小鼠单克隆抗体AR

20273

100μl

308.00美元

单克隆

小鼠

nonconjugated

1A9D12

免疫印迹, 酶联免疫吸附测定

小鼠单克隆抗体AR

人类

1A9D12;

小鼠IgG1

100μl

4℃;-20℃为长期储存

AR: androgen receptor. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Purified recombinant fragment of AR (aa689-919) expressed in E. Coli. ;

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000

1. Cancer Res. 2006 Nov 15;66(22):11077-83. ; 2. Mol Cell Biol. 2007 Oct;27(20):7125-42.

308.00美元

单克隆抗体

KD;AIS;TFM;DHTR;SBMA