抗体

小鼠单克隆抗体CD45

20298

100μl

308.00美元

单克隆

小鼠

nonconjugated

4A8A4C7A2

免疫印迹, 酶联免疫吸附测定, 免疫组化

小鼠单克隆抗体CD45

人类

4A8A4C7A2;

小鼠IgG1

100μl

4℃;-20℃为长期储存

CD45, also known as TPRC(protein tyrosine phosphatase, receptor type, C). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Purified recombinant fragment of CD45 expressed in E. Coli. ; ;

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000

1. Biol Chem. 2008 May;389(5):561-8. ; 2. Immunology. 2008 Dec;125(4):558-69.

308.00美元

单克隆抗体

LCA;LY5;B220;CD45;T200;CD45R;GP180;蛋白酪氨酸磷酸酶受体C