湖南远泰生物技术有限公司

抗体

小鼠单克隆抗体CD80

20341

100μl

308.00美元

单克隆

小鼠

2A2;

酶联免疫吸附测定, 免疫组化, 免疫细胞化学

20341

小鼠单克隆抗体CD80

人类

2A2;

小鼠IgG1

100μl

4℃;-20℃为长期储存

The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans. Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body. Osteoclast differentiation is inhibited by osteoprotegerin; Estrogen stimulates osteoprotegerin production.

Purified recombinant fragment of CD80 expressed in E. Coli.

腹水含0.03% 叠氮化钠

ELISA: 1/10000;IHC: 1/200 - 1/1000;ICC: 1/200 - 1/1000

1. Transplant Proc. 2008 Oct;40(8):2729-33. ; 2. Nat Med. 2007 Dec;13(12):1440-9.

308.00美元

单克隆抗体

55kDa

CD28LG;LAB7;B7.1