抗体

小鼠单克隆抗体CD40

20366

100μl

308.00美元

单克隆

小鼠

nonconjugated

9G10

酶联免疫吸附测定, 免疫细胞化学

小鼠单克隆抗体CD40

人类

9G10;

小鼠IgG1

100μl

4℃;-20℃为长期储存

CD40 molecule, TNF receptor superfamily member 5. It is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Purified recombinant fragment of CD40 expressed in E. Coli.

腹水含0.03% 叠氮化钠

ELISA: 1/10000;ICC: 1/200 - 1/1000

1. Clin Cancer Res. 2003 Feb;9(2):722-8. ; 2. Clin Cancer Res. 2003 Feb;9(2):619-24. ; 3. Immunity. 1999 Sep;11(3):339-48.

308.00美元

单克隆抗体

p50;Bp50;CDW40;TNFRSF5