抗体

小鼠单克隆抗体CD38

20413

100μl

308.00美元

单克隆

小鼠

nonconjugated

6E12D

免疫印迹, 酶联免疫吸附测定, 免疫组化

小鼠单克隆抗体CD38

人类

6E12D;

小鼠IgG1

100μl

4℃;-20℃为长期储存

CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lym- phocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabo- lites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.

纯化重组片段对应于人CD38在大肠杆菌中表达

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000

1. Trends Biochem Sci. 1992 Dec;17(12):495. ; 2. J Cell Biol. 1999 Sep 6;146(5):1161-72. ; 3. Exp Hematol. 2002 Jun;30(6):582-9. ; 4. Mol Immunol. 2006 Mar;43(7):1029-39. ;

308.00美元

单克隆抗体

34kDa

T10;CD38