抗体

小鼠单克隆抗体GSK3B

30006

100μl

308.00美元

单克隆

小鼠

nonconjugated

3D10

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪

小鼠单克隆抗体GSK3B

Human; Mouse; Monkey; Rat;

3D10;

小鼠IgG2a

100μl

4℃;-20℃为长期储存

Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription factors and structural proteins, and is part of the signal transduction cascade of a large number of growth factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt: Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β, S6K, RSK, PKA and PKC), dephosphorylation (PP1 and PP2A), and by binding to protein complexes (with beta-catenin, axin, CK1 and the APC complex).

纯化重组片段对应于人GSK3B在大肠杆菌中表达.;

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000;ICC: 1/200 - 1/1000;FCM: 1/200 - 1/400

1. EMBO J. 1998 Mar 2;17(5):1371-84. ; ; 2. Curr Biol. 2001 Jan 9;11(1):44-9. ; ; 3. Cancer Lett. 2003 Sep 25;199(2):201-8.

308.00美元

单克隆抗体

46kDa

GSK-3β;GSK3乙