湖南远泰生物技术有限公司

抗体

小鼠单克隆抗体CDC2

30038

100μl

308.00美元

单克隆

小鼠

8C5A6;

免疫印迹, 酶联免疫吸附测定, 免疫组化

30038

小鼠单克隆抗体CDC2

人类

8C5A6;

小鼠IgG1

100μl

4℃;-20℃为长期储存

The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

Purified recombinant fragment of CDC2 expressed in E. Coli.

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000

1. Mol Biol Cell. 2008 Aug;19(8):3536-43. ; 2. Eur J Cancer. 2009 May;45(8):1466-73.

308.00美元

单克隆抗体

34kDa

CDC2;CDC28A;P34CDC2;MGC111195;DKFZp686L20222;CDK1