抗体

小鼠单克隆抗体EPCAM

30049

100μl

308.00美元

单克隆

小鼠

nonconjugated

7E11

免疫印迹, 酶联免疫吸附测定, 免疫组化

小鼠单克隆抗体EPCAM

人类

7E11;

小鼠IgG1

100μl

4℃;-20℃为长期储存

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.Tissue specificity: This protein is expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas.ABCAM:Epithelial Cell Adhesion Molecule (EpCAM) is a 40 kDa cell surface antigen. This antigen has been identified independently by a number of groups, and has been known by a variety of names. Several monoclonal antibodies have been raised against EpCAM, many of which have been described as tumour specific molecules on carcinomas. EpCAM is a Type 1 transmembrane glycoprotein. It is expressed on the basolateral membrane of cells by the majority of epithelial tissues, with the exception of adult squamous epithelium and some specific epithelial cell types including hepatocytes and gastric epithelial cells. EpCAM expression has been reported to be a possible marker of early malignancy, with expression being increased in tumour cells, and de novo expression being seen in dysplastic squamous epithelium.BIOLEGEND:This cell surface, glycosyl;ated 40kD protein is highly expressed in the bone marrow, colon, lung, and most normal epithelial cells and is expressed on carcinomas of gastrointestinal origin.

纯化重组片段对应于人EPCAM在大肠杆菌中表达。;

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000

1. Int J Oncol. 2007 Jan;30(1):171-9. ; 2. Int J Cancer. 2008 Jul 15;123(2):484-9.

308.00美元

单克隆抗体

35kDa

ESA;KSA;M4S1;MK-1;DIAR5;EGP-2;EGP40;KS1/4;MIC18;TROP1;TACSTD1;EPCAM