抗体

小鼠单克隆抗体INHA

30113

100μl

308.00美元

单克隆

小鼠

nonconjugated

4 E2

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 免疫细胞化学

小鼠单克隆抗体INHA

人类;小鼠

4E2;

小鼠IgG1

100μl

4℃;-20℃为长期储存

Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Inhibins are also involved in regulating diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins, as inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibin has 2 subunits (alpha and beta) that are coded by separate genes. The alpha subunit determines whether inhibin or activin will be produced. The alpha subunit remains constant, such that the various types of inhibin are defined by the beta subunit (a,b,c,d). Inhibin A is a dimer of alpha and beta A. Inhibin B is a dimer of alpha and beta B. Proteolytic processing yields a number of inhibin alpha bioactive forms: the 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N terminal propeptide linked through a disulfide bond to the mature alpha chain, and the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono or diglycosylated, causing the mass difference.

纯化重组片段对应于人INHA在大肠杆菌中表达

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000;ICC: 1/200 - 1/1000

1. Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3567-72. ; 2. Acta Histochem. 2009;111(4):360-5. ; 3. Hum Reprod. 2009 Aug;24(8):2023-8.

308.00美元

单克隆抗体

40kDa

INHA