抗体

小鼠单克隆抗体CDH1

30121

100μl

308.00美元

单克隆

小鼠

nonconjugated

7H12

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 流式细胞仪

小鼠单克隆抗体CDH1

Human; Mouse; Monkey

7H12;

小鼠IgG1

100μl

4℃;-20℃为长期储存

E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.

纯化重组片段对应于人CDH1在大肠杆菌中表达

腹水含0.03% 叠氮化钠。;

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000;FCM: 1/200 - 1/400

1. Nat Genet. 2009 Dec;41(12):1330-4. ; 2. Zhonghua Zhong Liu Za Zhi. 2009 Jul;31(7):515-9. ; 3. J Biol Chem. 2010 Feb 26;285(9):6658-69.

308.00美元

单克隆抗体

135kDa

UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1