抗体

小鼠单克隆抗体FOXD3

30128

100μl

单克隆

小鼠

未共轭

5G9

小鼠单克隆抗体FOXD3

Human; Mouse; Monkey

5G9;

小鼠IgG1

100μl

4℃;-20℃为长期储存

FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development . This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation . FoxD3 is required for the maintenance of the mammalian neural crest; FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures . FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells .Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis .Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined .

纯化重组片段对应于人FOXD3在大肠杆菌中表达

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000

1. Blood. 1993 Jun 1;81(11):2854-9. ; 2. Am J Hum Genet. 2001 Mar;68(3):627-41. ;

单克隆抗体

48kDa

AIS1; HFH2; Genesis; FOXD3