抗体

小鼠单克隆抗体NACC1

30137

100μl

308.00美元

单克隆

小鼠

nonconjugated

6H2

免疫印迹, 酶联免疫吸附测定, 免疫组化

小鼠单克隆抗体NACC1

人类

6H2;

小鼠IgG1

100μl

4℃;-20℃为长期储存

NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors . NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system . NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene . The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway . NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4 . Tissue specificity: Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer .

纯化重组片段对应于人NACC1在大肠杆菌中表达

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000

1. Neuroscience. 2002;110(3):421-9. ; 2. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5.

308.00美元

单克隆抗体

58kDa

NAC1;BEND8;新来港学童-1;BTBD14B;FLJ37383;NACC1