抗体

小鼠单克隆抗体snail 1锌指蛋白

30145

100μl

341.00美元

单克隆

小鼠

nonconjugated

6D2

免疫印迹, 酶联免疫吸附测定

小鼠单克隆抗体snail 1锌指蛋白

人类

6D2;

小鼠IgG1

100μl

4℃;-20℃为长期储存

Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.

纯化重组片段对应于人snail 1锌指蛋白在大肠杆菌中表达

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000

1. Exp Cell Res. 2008 Aug 1;314(13):2448-53. ; 2. Mol Cell Biol. 2008 Aug;28(15):4772-81.

341.00美元

单克隆抗体

29kDa

SNA;SNAH;SLUGH2;dJ710H13.1;snail 1锌指蛋白