抗体

小鼠单克隆抗体CTCF

30149

100μl

308.00美元

单克隆

小鼠

nonconjugated

1D11

免疫印迹, 酶联免疫吸附测定

小鼠单克隆抗体CTCF

Human; Monkey

1D11;

小鼠IgG1

100μl

4℃;-20℃为长期储存

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.Tissue specificity: Ubiquitous. Absent in primary spermatocytes.

纯化重组片段对应于人CTCF在大肠杆菌中表达

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000

1. J Mol Med. 2008 Sep;86(9):1057-66. ; 2. J Exp Med. 2008 Apr 14;205(4):785-98. ; 3. EMBO J. 2008 Feb 20;27(4):654-66.

308.00美元

单克隆抗体

83kDa

CTCF