抗体

小鼠单克隆抗体毛细血管扩张性共济失调症突变蛋白

30173

100μl

341.00美元

单克隆

小鼠

nonconjugated

5-C-5

免疫印迹, 酶联免疫吸附测定

小鼠单克隆抗体毛细血管扩张性共济失调症突变蛋白

人类

5C5;

小鼠IgG1

100μl

4℃;-20℃为长期储存

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.

纯化重组片段对应于人毛细血管扩张性共济失调症突变蛋白在大肠杆菌中表达

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000

1. Am J Hum Genet. 2008 Aug;83(2):243-53. ; 2. Mol Cell. 2008 Jul 25;31(2):167-77.

341.00美元

单克隆抗体

351kDa

AT1;ATA;ATC;ATD;ATE;ATDC;TEL1;TELO1;MGC74674;DKFZp781A0353;毛细血管扩张性共济失调症突变蛋白