抗体

小鼠单克隆抗体SMAD家族成员2

30242

100μl

341.00美元

单克隆

小鼠

nonconjugated

5G7

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪

小鼠单克隆抗体SMAD家族成员2

人类

5G7;

小鼠IgG1

100μl

4℃;-20℃为长期储存

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed.

纯化重组片段对应于人SMAD家族成员2在大肠杆菌中表达。;

腹水含0.03% 叠氮化钠

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000;ICC: 1/200 - 1/1000;FCM: 1/200 - 1/400

1. J Biol Chem. 2009 Dec 4;284(49):34145-56. ; 2. Cloning Stem Cells. 2009 Sep;11(3):427-35.

341.00美元

单克隆抗体

52kDa

JV18;MADH2;MADR2;JV18-1;hMAD-2;hSMAD2;MGC22139;MGC34440