抗体

小鼠单克隆抗体RAF1

30325

0.1毫克

341.00美元

单克隆

小鼠

nonconjugated

4G4

免疫印迹, 酶联免疫吸附测定, 免疫组化, 流式细胞仪

小鼠单克隆抗体RAF1

人类

4G4;

小鼠IgG1

0.1毫克

4℃;-20℃为长期储存

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

纯化重组片段对应于人RAF1在大肠杆菌中表达。;

Purified antibody in PBS with 0.05% sodium azide

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000;FCM: 1/200 - 1/400

1. Am J Hum Genet. 2009 Nov;85(5):628-42. ; 2. Mol Cancer Res. 2009 Oct;7(10):1635-44. ;

341.00美元

单克隆抗体

NS5; CRAF; Raf-1; c-Raf