抗体

小鼠单克隆抗体肿瘤坏死因子受体超家族成员6

30328

0.1毫克

341.00美元

单克隆

小鼠

nonconjugated

4F8D6

免疫印迹, 酶联免疫吸附测定, 流式细胞仪

小鼠单克隆抗体肿瘤坏死因子受体超家族成员6

人类

4F8D6;

小鼠IgG1

0.1毫克

4℃;-20℃为长期储存

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

纯化重组片段对应于人肿瘤坏死因子受体超家族成员6在大肠杆菌中表达。;

Purified antibody in PBS with 0.05% sodium azide

ELISA: 1/10000;WB: 1/500 - 1/2000;FCM: 1/200 - 1/400

Int J Surg Pathol. 2010 Dec;18(6):493-8 ; Am J Hum Genet. 2009 Nov;85(5):628-42 ;

341.00美元

单克隆抗体

37.7kDa

APT1;CD95;FAS1;ApoE基因-1;FASTM;ALPS1A;TNFRSF6