抗体

小鼠单克隆抗体SHH

30375

0.1毫克

341.00美元

单克隆

小鼠

nonconjugated

5H4

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 流式细胞仪

小鼠单克隆抗体SHH

Human; Mouse; Monkey

5H4;

小鼠IgG1

0.1毫克

4℃;-20℃为长期储存

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

纯化重组片段对应于人SHH(AA: 26-161)在大肠杆菌中表达。;;

Purified antibody in PBS with 0.05% sodium azide

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000;FCM: 1/200 - 1/400

1.Br J Cancer. 2010 Feb 16;102(4):738-47. ; 2.Mol Cancer. 2009 Dec 16;8:123. ;

341.00美元

单克隆抗体

49.6kDa

TPT;HHG1;HLP3;HPE3;SMMCI;TPTPS;MCOPCB5