湖南远泰生物技术有限公司

抗体

小鼠单克隆抗体PAX5

30395

0.1毫克

341.00美元

单克隆

小鼠

7D3;

免疫印迹, 酶联免疫吸附测定, 免疫组化

30395

小鼠单克隆抗体PAX5

人类;

7D3;

小鼠IgG1

0.1毫克

4℃;-20℃为长期储存

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

纯化重组片段对应于人PAX5(AA: 235-382)在大肠杆菌中表达

Purified antibody in PBS with 0.05% sodium azide

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000

1.Cancer Res. 2011 Dec 15;71(24):7345-50. 2.Am J Clin Pathol. 2010 Jan;133(1):41-8.

341.00美元

单克隆抗体

45kDa

BSAP