产品简要
公司名称 :
湖南远泰生物技术有限公司
产品类型 :
抗体
产品名称 :
小鼠单克隆抗体乳腺癌1号基因
目录 :
30509
规格 :
0.1毫克
价格 :
341.00美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
6C6D2
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
更多信息或购买 :
图像
图像 1 :
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
图像 2 :
Figure 1: Western blot analysis using BRCA1 mAb against human BRCA1 recombinant protein. (Expected MW is 37.5 kDa)
图像 3 :
Figure 2: Western blot analysis using BRCA1 mAb against HEK293 (1) and BRCA1 (AA: 229-335)-hIgGFc transfected HEK293 (2) cell lysate.
产品信息
目录 :
30509
标题 :
小鼠单克隆抗体乳腺癌1号基因
物种 :
人类;
克隆 :
6C6D2;
同种型 :
小鼠IgG1
规格 :
0.1毫克
储存 :
4℃;-20℃为长期储存
描述 :
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. ; ; ;
免疫原 :
纯化重组片段对应于人乳腺癌1号基因(AA: 229-335)在大肠杆菌中表达
配方 :
Purified antibody in PBS with 0.05% sodium azide
应用 :
ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000
参考文献 :
1. Cancer Res. 2013 Jan 15;73(2):706-15. ; 2. J Biol Chem. 2012 Nov 23;287(48):40618-28. ;
标价(美元) :
341.00美元
类型 :
单克隆抗体
分子量 :
207.7kDa
别名 :
IRIS;PSCP;BRCAI;BRCC1;PNCA4;RNF53;BROVCA1;PPP1R53
更多信息或购买 :
公司信息
湖南远泰生物技术有限公司
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