抗体

小鼠单克隆抗体血管内皮生长因子A

30971

0.1毫克

341.00美元

单克隆

小鼠

nonconjugated

6G5B5

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪

小鼠单克隆抗体血管内皮生长因子A

人类;

6G5B5;

小鼠IgG1

0.1毫克

4℃;-20℃为长期储存

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.;

纯化重组片段对应于人血管内皮生长因子A(AA: 207-371)在大肠杆菌中表达

Purified antibody in PBS with 0.05% sodium azide

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC:;ICC: 1/200 - 1/1000;FCM:

1.Oncol Rep. 2014 Dec;32(6):2359-64. ; 2.Eur J Cancer. 2014 Nov;50(16):2855-65. ;

341.00美元

单克隆抗体

27kDa

VPF;血管内皮生长因子;MVCD1