产品简要
公司名称 :
ProSci
产品类型 :
抗体
产品名称 :
趋化因子受体4抗体
目录 :
1009
规格 :
0.02毫克, 0.1毫克
价格 :
79, 315美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀, 流式细胞仪
更多信息或购买 :
文章摘录数: 1
产品信息
目录代码 :
1009
产品名称 :
趋化因子受体4抗体
宿主物种 :
兔
克隆性 :
多克隆
共轭 :
未共轭
产品类型 :
一抗
规格 :
0.02毫克, 0.1毫克
标价 :
79, 315美元
抗体亚型 :
IgG
交叉活性 :
人类, 小鼠
背景 :
CXCR4 Antibody: Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites.
别名 :
CXCR4 Antibody: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E
免疫原 :
CXCR4 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human CXCR4.
特异性 :
CXCR4 Antibody is predicted to not cross-react with other CXCR familiy members.
纯度 :
CXCR4 Antibody is affinity chromatography purified via peptide column.
缓冲液 :
CXCR4 Antibody is supplied in PBS containing 0.02% sodium azide.
浓度 :
1毫克/毫升
用途 :
E, 免疫印迹, 免疫细胞化学, 免疫沉淀, IF, 流式细胞仪
应用摘要 :
CXCR4 antibody can be used for Western blot at 1 - 2 g/mL dilution and for immunoprecipitation and immunocytochemistry at 10 g/mL. Immunofluorescence starting at 20 g/mL. Flow Cytometry at 0.1 g/ml
储存 :
CXCR4 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
一般参考 :
Dimitrov DS. Cell 1997;91:721-730
一般参考 :
Feng Y et al. Science 1996;272:872-7
一般参考 :
Berson JF et al. J Virol 1996;70:6288-95
一般参考 :
Doranz BJ et al. Cell 1996;85:1149-1158
更多信息或购买 :
公司信息
ProSci
12170 Flint Place
Poway, CA 92064
Poway, CA 92064
info@prosci-inc.com
www.prosci-inc.com1-888-513-9525 1-858-513-2638
公司总部: 美国