产品简要
信息索取 :
公司名称 :
ProSci
产品类型 :
抗体
产品名称 :
DR4抗体
目录 :
1139
规格 :
0.02毫克, 0.1毫克
价格 :
79, 315美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 流式细胞仪, immunohistochemistry - free floating section
更多信息或购买 :
文章摘录数: 8
| 已发表的文献中的应用方法／种属／稀释度 | 参考文献 |
|---|---|
| |
| Lonergan M, Aponso D, Marvin K, Helliwell R, Sato T, Mitchell M, et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), TRAIL receptors, and the soluble receptor osteoprotegerin in human gestational membranes and amniotic fluid during pregnancy and labor at term and preterm. J Clin Endocrinol Metab. 2003;88:3835-44 pubmed
|
| |
| Malhi H, Barreyro F, Isomoto H, Bronk S, Gores G. Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. Gut. 2007;56:1124-31 pubmed
|
| Bäurle J, Frischmuth S, Kranda K. TRAIL-related death receptors in normal, Lurcher and weaver mutant mouse brain. Neurosci Lett. 2004;372:46-51 pubmed
|
Drosopoulos K, Roberts M, Cermak L, Sasazuki T, Shirasawa S, Andera L, et al. Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. J Biol Chem. 2005;280:22856-67 pubmed
|
产品信息
目录代码 :
1139
产品名称 :
DR4抗体
宿主物种 :
兔
克隆性 :
多克隆
共轭 :
未共轭
产品类型 :
一抗
规格 :
0.02毫克, 0.1毫克
标价 :
79, 315美元
抗体亚型 :
IgG
交叉活性 :
人类
背景 :
DR4 Antibody: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL2, 3, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF- B activation in many tissues and cells.
别名 :
DR4 Antibody: DR4, APO2, CD261, TRAILR1, TRAILR-1, DR4, Tumor necrosis factor receptor superfamily member 10A, Death receptor 4, TRAIL receptor 1
免疫原 :
DR4 antibody was raised against a peptide corresponding to 19 amino acids near the carboxy terminus of human DR4 protein.
纯度 :
DR4 Antibody is Antibody is affinity chromatography purified via peptide column.
缓冲液 :
DR4 Antibody is supplied in PBS containing 0.02% sodium azide.
浓度 :
1毫克/毫升
用途 :
E, 免疫印迹, 免疫细胞化学
应用摘要 :
DR4 antibody can be used for detection of DR4 expression by Western blot at 0.5 g/mL. Antibody can also be used for immunocytochemistry starting at 10 g/mL.
储存 :
DR4 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
一般参考 :
Pan G; O'Rourke K; Chinnaiyan AM; O'Rourke K; Gentz R; Ebner R; Ni J; Dixit VM. The receptor for the cytotoxic ligand TRAIL. Science; 1997;276:111-113
一般参考 :
Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, Sutherland GR, Smith TD, Rauch C, Smith CA, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995;3:673-682
一般参考 :
Pitti RM; Marsters SA; Ruppert S; Donahue CJ; Moore A; Ashkenazi A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 1996;271:12687-90
一般参考 :
Schneider P, Thome M, Burns K, Bodmer JL, Hofmann K, Kataoka T, Holler N, Tschopp J. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF- B. Immunity 1997;7:831-836 (RD1299)
更多信息或购买 :
公司信息
ProSci
12170 Flint Place
Poway, CA 92064
Poway, CA 92064
info@prosci-inc.com
www.prosci-inc.com1-888-513-9525 1-858-513-2638
公司总部: 美国