产品简要
公司名称 :
ProSci
产品类型 :
抗体
产品名称 :
XIAP抗体
目录 :
3331
规格 :
0.02毫克, 0.1毫克
价格 :
79, 315美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学
更多信息或购买 :
文章摘录数: 1
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000
Xu L, Ouyang Y, Xiong X, Stary C, Giffard R. Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia. Exp Neurol. 2015;264:1-7 pubmed 出版商
产品信息
目录代码 :
3331
产品名称 :
XIAP抗体
宿主物种 :
克隆性 :
多克隆
共轭 :
未共轭
产品类型 :
一抗
规格 :
0.02毫克, 0.1毫克
标价 :
79, 315美元
抗体亚型 :
IgG
交叉活性 :
人类, 小鼠
背景 :
XIAP Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The X-chromosome linked inhibitor of apoptosis (XIAP) contains 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases-3, -7, and -9. Upregulation of XIAP expression can protect cells from apoptosis induced by low level radiation; conversely, decreased XIAP expression by antisense targeting resulted in increased cell death following low level radiation. Two negative regulators, termed XAF-1 and Smac, can bind and inhibit XIAP activity.
别名 :
XIAP Antibody: API3, ILP1, MIHA, XLP2, BIRC4, IAP-3, hIAP3, hIAP-3, API3, IAP3, E3 ubiquitin-protein ligase XIAP, Baculoviral IAP repeat-containing protein 4, ILP
免疫原 :
XIAP antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human XIAP.
纯度 :
XIAP Antibody is affinity chromatography purified via peptide column.
缓冲液 :
XIAP Antibody is supplied in PBS containing 0.02% sodium azide.
浓度 :
1毫克/毫升
用途 :
E, 免疫印迹, 免疫组化, IF
应用摘要 :
XIAP antibody can be used for the detection of XIAP by Western blot at 0.5 to 2 g/mL. Antibody can also be used for immunohistochemistry starting at 2 g/mL. For immunofluorescence start at 10 g/mL.
储存 :
XIAP antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
一般参考 :
Schimmer AD. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res. 2004; 64:7183-90.
一般参考 :
Deveraux QL, Takahashi R, Savesan GS, et al. X-linked IAP is a direct inhibitor of cell-death proteases. Nature 1997; 388:300-4.
一般参考 :
Deveraux QL, Leo E, Stennicke HR, et al. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J. 1999; 18:5242-51.
一般参考 :
Holcik M, Yeh C, Korneluk RG, et al. Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death. Oncogene 2000; 19:4174-7.
更多信息或购买 :
公司信息
ProSci
12170 Flint Place
Poway, CA 92064
info@prosci-inc.com
www.prosci-inc.com
1-888-513-9525 1-858-513-2638
公司总部: 美国