抗体

胱氨酸-天冬氨酸蛋白酶7抗体

3465

0.02毫克, 0.1毫克

79, 315美元

多克隆

兔

nonconjugated

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化

胱氨酸-天冬氨酸蛋白酶7抗体

兔

多克隆

未共轭

一抗

0.02毫克, 0.1毫克

79, 315美元

IgG

人类, 小鼠, 大鼠

Caspase-7 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression.

Caspase-7 Antibody: MCH3, CMH-1, LICE2, CASP-7, ICE-LAP3, MCH3, Caspase-7, Apoptotic protease Mch-3

Caspase-7 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Caspase-7.

Depending on cell lines or tissues used, other cleavage products may be observed.

Caspase-7 Antibody is affinity chromatography purified via peptide column.

Caspase-7 Antibody is supplied in PBS containing 0.02% sodium azide.

1毫克/毫升

E, 免疫印迹, 免疫组化

Casp-7 antibody can be used for the detection of Caspase-7 by Western blot at 0.5 to 1 g/mL. Antibody can also be used for immunohistochemistry starting at 2 g/mL.

Caspase-7 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.

Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.

Wolf BB and Green DR. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 1999; 274:20049-52.

Juan TSC, McNiece IK, Argento JM, et al. Identification and mapping of Casp7, a cysteine protease resembling CPP32b, Interleukin-1b converting enzyme, and CED-3. Genomics 1997; 40:86-93.