产品简要
公司名称 :
ProSci
产品类型 :
抗体
产品名称 :
胱氨酸-天冬氨酸蛋白酶8抗体
目录 :
3473
规格 :
0.02毫克, 0.1毫克
价格 :
79, 315美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学
更多信息或购买 :
文章摘录数: 1
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 图 s1j
Strilic B, Yang L, Albarrán Juárez J, Wachsmuth L, Han K, Müller U, et al. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature. 2016;536:215-8 pubmed
产品信息
目录代码 :
3473
产品名称 :
胱氨酸-天冬氨酸蛋白酶8抗体
宿主物种 :
克隆性 :
多克隆
共轭 :
未共轭
产品类型 :
一抗
规格 :
0.02毫克, 0.1毫克
标价 :
79, 315美元
抗体亚型 :
IgG
交叉活性 :
人类, 小鼠, 大鼠
背景 :
Caspase-8 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation. FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis.
别名 :
Caspase-8 Antibody: CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8, Caspase-8, Apoptotic cysteine protease, CASP-8
免疫原 :
Caspase-8 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Caspase-8 isoform A.
特异性 :
Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.
纯度 :
Caspase-8 Antibody is affinity chromatography purified via peptide column.
缓冲液 :
Caspase-8 Antibody is supplied in PBS containing 0.02% sodium azide.
浓度 :
1毫克/毫升
用途 :
E, 免疫印迹, 免疫细胞化学, IF
应用摘要 :
Caspase-8 antibody can be used for the detection of caspase-8 by Western blot at 0.5 to 2 g/mL. Antibody can also be used for immunocytochemistry starting at 2 g/mL. For immunofluorescence start at 20 g/mL.
储存 :
Caspase-8 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
一般参考 :
Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.
一般参考 :
Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.
一般参考 :
Wolf BB and Green DR. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 1999; 274:20049-52.
一般参考 :
Muzio M, Chinnaiyan AM, Kischkel FC, et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 1996; 85:817-27.
更多信息或购买 :
公司信息
ProSci
12170 Flint Place
Poway, CA 92064
info@prosci-inc.com
www.prosci-inc.com
1-888-513-9525 1-858-513-2638
公司总部: 美国