产品简要
公司名称 :
ProSci
产品类型 :
抗体
产品名称 :
ORAI1抗体
目录 :
4041
规格 :
0.02毫克, 0.1毫克
价格 :
79, 315美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学
更多信息或购买 :
ProSci 产品网页
文章摘录数: 6
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 图 s2
Albarrán L, Lopez J, Amor N, Martin Cano F, Berna Erro A, Smani T, et al. Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry. Sci Rep. 2016;6:24452 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Huang Y, Chang S, Harn H, Huang H, Lin H, Shen M, et al. Mechanosensitive store-operated calcium entry regulates the formation of cell polarity. J Cell Physiol. 2015;230:2086-97 pubmed 出版商
Kuras Z, Yun Y, Chimote A, Neumeier L, Conforti L. KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells. PLoS ONE. 2012;7:e43859 pubmed 出版商
Lefievre L, Nash K, Mansell S, Costello S, Punt E, Correia J, et al. 2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm. Biochem J. 2012;448:189-200 pubmed 出版商
Edwards J, Murphy R, Cully T, von Wegner F, Friedrich O, Launikonis B. Ultra-rapid activation and deactivation of store-operated Ca(2+) entry in skeletal muscle. Cell Calcium. 2010;47:458-67 pubmed 出版商
Bisaillon J, Motiani R, Gonzalez Cobos J, Potier M, Halligan K, Alzawahra W, et al. Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration. Am J Physiol Cell Physiol. 2010;298:C993-1005 pubmed 出版商
产品信息
目录代码 :
4041
产品名称 :
ORAI1抗体
宿主物种 :
兔
克隆性 :
多克隆
共轭 :
未共轭
产品类型 :
一抗
规格 :
0.02毫克, 0.1毫克
标价 :
79, 315美元
抗体亚型 :
IgG
交叉活性 :
人类, 小鼠
背景 :
ORAI1 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.
别名 :
ORAI1 Antibody: IMD9, ORAT1, CRACM1, TMEM142A, Calcium release-activated calcium channel protein 1, Protein orai-1
免疫原 :
ORAI1 antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human ORAI1.
特异性 :
This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
纯度 :
ORAI1 Antibody is affinity chromatography purified via peptide column.
缓冲液 :
ORAI1 Antibody is supplied in PBS containing 0.02% sodium azide.
浓度 :
1毫克/毫升
用途 :
E, 免疫印迹, 免疫组化, IF
应用摘要 :
ORAI1 antibody can be used for detection of ORAI1 by Western blot at 1 g/mL. Antibody can also be used for immunohistochemistry starting at 10 g/mL. For immunofluorescence start at 20 g/mL.
储存 :
ORAI1 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
一般参考 :
Lewis RS. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 2001; 19:497-521.
一般参考 :
Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006; 441:179-85.
一般参考 :
Soboloff J, Spassova MA, Dziadek MA, et al. Calcium signals mediated by STIM and Orai proteins - a new paradigm in inter-organelle communication. Biochim. Biophys. Acta. 2006; 1763:1161-8.
更多信息或购买 :
ProSci 产品网页
公司信息
ProSci
12170 Flint Place
Poway, CA 92064
info@prosci-inc.com
www.prosci-inc.com
1-888-513-9525 1-858-513-2638
公司总部: 美国