产品简要
公司名称 :
ProSci
产品类型 :
抗体
产品名称 :
PDL-1抗体
目录 :
4059
规格 :
0.02毫克, 0.1毫克
价格 :
79, 315美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 4
出版应用/物种/样品/稀释 | 参考文献 |
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产品信息
目录代码 :
4059
产品名称 :
PDL-1抗体
宿主物种 :
兔
克隆性 :
多克隆
共轭 :
未共轭
产品类型 :
一抗
规格 :
0.02毫克, 0.1毫克
标价 :
79, 315美元
抗体亚型 :
IgG
交叉活性 :
人类, 小鼠, 大鼠
背景 :
PDL-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. PDL-1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. At least two isoforms of PDL-1 are known to exist; this antibody is specific to the larger isoform.
别名 :
PDL-1 Antibody: B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, Programmed cell death 1 ligand 1, B7 homolog 1
免疫原 :
PDL-1 antibody was raised against a 17 amino acid synthetic peptide from near the center of human PDL-1.
特异性 :
PDL-1 antibody has no cross-reactivity to PDL-2.
纯度 :
PDL-1 Antibody is affinity chromatography purified via peptide column.
缓冲液 :
PDL-1 Antibody is supplied in PBS containing 0.02% sodium azide.
浓度 :
1毫克/毫升
用途 :
E, 免疫印迹, 免疫组化, IF, 流式细胞仪
应用摘要 :
PDL-1 antibody can be used for detection of PDL-1 by Western blot at 0.5 - 1 g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 g/mL. For immunofluorescence start at 20 g/mL. Flow cytometry at 0.5 g/ml.
储存 :
PDL-1 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
一般参考 :
Holling TM, Schooten E, and van Den Elsing PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum. Immunol. 2004; 65:282-90.
一般参考 :
Ishida Y, Agata Y, Shibahara K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992; 11:3887-95.
一般参考 :
LaGier J and Pober JS. Immune accessory functions of human endothelial cells are modulated by overexpression of B7-H1 (PDL1). Hum. Immunol. 2006; 67:568-78.
更多信息或购买 :
公司信息
ProSci
12170 Flint Place
Poway, CA 92064
Poway, CA 92064
info@prosci-inc.com
www.prosci-inc.com1-888-513-9525 1-858-513-2638
公司总部: 美国
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