产品简要
公司名称 :
ProSci
产品类型 :
抗体
产品名称 :
STIM1抗体
目录 :
4119
规格 :
0.02毫克, 0.1毫克
价格 :
79, 315美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫组化-冰冻切片
更多信息或购买 :
ProSci 产品网页
文章摘录数: 5
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 大鼠; 1:500; 图 s1
Garcia Alvarez G, Lu B, Yap K, Wong L, Thevathasan J, Lim L, et al. STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs. Mol Biol Cell. 2015;26:1141-59 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 1:1500
  • 免疫印迹; 大鼠; 1:500
Gemes G, Bangaru M, Wu H, Tang Q, Weihrauch D, Koopmeiners A, et al. Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury. J Neurosci. 2011;31:3536-49 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Edwards J, Murphy R, Cully T, von Wegner F, Friedrich O, Launikonis B. Ultra-rapid activation and deactivation of store-operated Ca(2+) entry in skeletal muscle. Cell Calcium. 2010;47:458-67 pubmed 出版商
Garcia Alvarez G, Shetty M, Lu B, Yap K, Oh Hora M, Sajikumar S, et al. Impaired spatial memory and enhanced long-term potentiation in mice with forebrain-specific ablation of the Stim genes. Front Behav Neurosci. 2015;9:180 pubmed 出版商
Lefievre L, Nash K, Mansell S, Costello S, Punt E, Correia J, et al. 2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm. Biochem J. 2012;448:189-200 pubmed 出版商
产品信息
目录代码 :
4119
产品名称 :
STIM1抗体
宿主物种 :
兔
克隆性 :
多克隆
共轭 :
未共轭
产品类型 :
一抗
规格 :
0.02毫克, 0.1毫克
标价 :
79, 315美元
抗体亚型 :
IgG
交叉活性 :
人类, 小鼠, 大鼠
背景 :
STIM1 Antibody: In T lymphocytes, the sole pathway for Ca 2+ entry following antigen-receptor binding is through store-operated Ca 2+ -release-activated Ca 2+ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca 2+ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca 2+ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca 2+ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca 2+ entry.
别名 :
STIM1 Antibody: GOK, TAM, IMD10, D11S4896E, GOK, Stromal interaction molecule 1
免疫原 :
STIM1 antibody was raised against a 24 amino acid synthetic peptide from near the carboxy terminus of human STIM1.
特异性 :
At least two isoforms of STIM1 are known to exist; this antibody will detect only the larger form. This STIM1 antibody is predicted to have no cross-reactivity to STIM2.
纯度 :
STIM1 Antibody is affinity chromatography purified via peptide column.
缓冲液 :
STIM1 Antibody is supplied in PBS containing 0.02% sodium azide.
浓度 :
1毫克/毫升
用途 :
E, 免疫印迹, 免疫组化
应用摘要 :
STIM1 antibody can be used for detection of STIM1 by Western blot at 1 - 2 g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 g/mL.
储存 :
STIM1 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
一般参考 :
Luik RM and Lewis RS. New insights into the molecular mechanisms of store-operated Ca 2+ signaling in T cells. Trends Mol. Med. 2007; 13:103-7.
一般参考 :
Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006; 441:179-85.
一般参考 :
Zhang SL, Yu Y, Roos J, et al. STIM1 is a Ca 2+ sensor that activates CRAC channels and migrates from the Ca 2+ store to the plasma membrane. Nature 2005; 437:902-5.
一般参考 :
Spassova MA, Soboloff J, He L-P, et al. STIM1 has a plasma membrane role in the activation of store-operated Ca2+ channels. Proc. Natl. Acad. Sci. USA 2006; 103:4040-5.
更多信息或购买 :
ProSci 产品网页
公司信息
ProSci
12170 Flint Place
Poway, CA 92064
info@prosci-inc.com
www.prosci-inc.com
1-888-513-9525 1-858-513-2638
公司总部: 美国