产品简要
公司名称 :
ProSci
产品类型 :
抗体
产品名称 :
ORAI1抗体[3F6H5]
目录 :
PM-5205
规格 :
0.02毫克, 0.1毫克
价格 :
79, 315美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
3F6H5
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学
更多信息或购买 :
ProSci 产品网页
文章摘录数: 1
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 图 1b
Kondratska K, Kondratskyi A, Yassine M, Lemonnier L, Lepage G, Morabito A, et al. Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma. Biochim Biophys Acta. 2014;1843:2263-9 pubmed 出版商
产品信息
目录代码 :
PM-5205
产品名称 :
ORAI1抗体[3F6H5]
宿主物种 :
小鼠
克隆性 :
单克隆
共轭 :
未共轭
产品类型 :
一抗
规格 :
0.02毫克, 0.1毫克
标价 :
79, 315美元
克隆 :
3F6H5
抗体亚型 :
IgG1
交叉活性 :
人类, 小鼠, 大鼠
背景 :
ORAI1 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
别名 :
ORAI1抗体[3F6H5]: IMD9, ORAT1, CRACM1, TMEM142A
免疫原 :
Mouse monoclonal ORAI1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1.
特异性 :
ORAI1 antibody is predicted to have no cross reactivity to other members in the ORAI family.
纯度 :
ORAI1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
缓冲液 :
ORAI1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
浓度 :
1毫克/毫升
用途 :
E, 免疫印迹, 免疫组化, IF
应用摘要 :
ORAI1 antibody can be used for detection of ORAI1 by Western blot at 1 - 2 g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 g/mL. For immunofluorescence start at 20 g/mL.
储存 :
ORAI1 monoclonal antibody can be stored at -20 C, stable for one year.
一般参考 :
Lewis RS. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 2001; 19:497-521.
一般参考 :
Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006; 441:179-85.
一般参考 :
Soboloff J, Spassova MA, Dziadek MA, et al. Calcium signals mediated by STIM and Orai proteins - a new paradigm in inter-organelle communication. Biochim. Biophys. Acta. 2006; 1763:1161-8.
更多信息或购买 :
ProSci 产品网页
公司信息
ProSci
12170 Flint Place
Poway, CA 92064
info@prosci-inc.com
www.prosci-inc.com
1-888-513-9525 1-858-513-2638
公司总部: 美国