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domestic rabbit
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人类, 小鼠
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免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫印迹基因敲除验证
文章摘录数: 319
  • 免疫印迹; 人类; 图 6a
Guo S, Liu R, Wen Y, Liu L, Yuan L, Li Y, et al. Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis. Cancer Lett. 2020;468:27-40 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3e
Wang Q, Jia S, Jiao Y, Xu L, Wang D, Chen X, et al. SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway. Int J Med Sci. 2019;16:1573-1582 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 4f
  • 免疫印迹; 人类; 图 4e
Liu G, Zhang Q, Xia L, Shi M, Cai J, Zhang H, et al. RNA-binding protein CELF6 is cell cycle regulated and controls cancer cell proliferation by stabilizing p21. Cell Death Dis. 2019;10:688 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2g
Liu C, Wang X, Zhang Y. The Roles of HK2 on Tumorigenesis of Cervical Cancer. Technol Cancer Res Treat. 2019;18:1533033819871306 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:800; 图 7b
  • 免疫印迹; 人类; 1:1000; 图 3e, 5d
Sun B, Zhao X, Ming J, Liu X, Liu D, Jiang C. Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma. Oncogene. 2019;38:6142-6157 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1c
Khanal T, Leung Y, Jiang W, Timchenko N, Ho S, Kim K. NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries. FASEB J. 2019;:fj201801881RR pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 7b
  • 免疫印迹; 小鼠; 图 5a
Feng F, Wang Z, Li R, Wu Q, Gu C, Xu Y, et al. Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2. Biomed Pharmacother. 2019;112:108669 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 5a
Zhu X, Wang K, Zhang K, Zhang T, Yin Y, Xu F. Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis. Int J Mol Sci. 2016;17: pubmed
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 3
Ren X, Liu H, Zhang M, Wang M, Ma S. Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo. Mol Med Rep. 2016;14:2431-8 pubmed 出版商
Wei M, Xie M, Zhang Z, Wei Y, Zhang J, Pan H, et al. Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer. Eur J Med Chem. 2020;206:112677 pubmed 出版商
Wu Z, Zhan Y, Wang L, Tong J, Zhang L, Lin M, et al. Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells. Biomed Pharmacother. 2020;130:110556 pubmed 出版商
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J. Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways. Nutr Cancer. 2020;:1-12 pubmed 出版商
Yang H, Chen Y, Jiang Y, Wang D, Yan J, Zhou Z. TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents. Exp Ther Med. 2020;20:1415-1422 pubmed 出版商
Wang X, Lin Y, Zheng Y. Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration. Mol Med Rep. 2020;22:2318-2328 pubmed 出版商
Zhang S, Wang C, Ma B, Xu M, Xu S, Liu J, et al. Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion. Cell Rep. 2020;32:107879 pubmed 出版商
Hao Y, Huang Y, Chen J, Li J, Yuan Y, Wang M, et al. Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling. Cell Prolif. 2020;53:e12869 pubmed 出版商
Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, et al. Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice. Phytomedicine. 2020;76:153216 pubmed 出版商
Liu J, Fu W, Zheng X, Li W, Ren L, Wang J, et al. Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest. Acta Pharmacol Sin. 2020;: pubmed 出版商
Wu H, Sun H, He Z, Chen X, Li Y, Zhao X, et al. The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models. Exp Cell Res. 2020;394:112093 pubmed 出版商
Ma Y, Yan R, Wan Q, Lv B, Yang Y, Lv T, et al. Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells. J Physiol Biochem. 2020;76:373-382 pubmed 出版商
Takasugi M, Firsanov D, Tombline G, Ning H, Ablaeva J, Seluanov A, et al. Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties. Nat Commun. 2020;11:2376 pubmed 出版商
Wu C, Guo E, Ming J, Sun W, Nie X, Sun L, et al. Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21. Mol Ther Oncolytics. 2020;17:306-319 pubmed 出版商
Zhang H, Ma Y, Wang M, Elsabagh M, Loor J, Wang H. Dietary supplementation of l-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction. Food Funct. 2020;11:4456-4470 pubmed 出版商
Wang L, Tan Z, Zhang Y, Kady Keita N, Liu H, Zhang Y. ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells. Int J Oncol. 2020;56:1162-1174 pubmed 出版商
Chen Y, Jiang H, Wang T, He D, Tian R, Cui Z, et al. In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs' cleavage by CRISPR/Cas13a system. Antiviral Res. 2020;178:104794 pubmed 出版商
Jing X, Chen Y, Chen Y, Shi G, Lv S, Cheng N, et al. Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion. Cancer Manag Res. 2020;12:2185-2194 pubmed 出版商
Wu Q, Zhao M, Huang G, Zheng Z, Chen Y, Zeng W, et al. Fibroblast Activation Protein (FAP) Overexpression Induces Epithelial-Mesenchymal Transition (EMT) in Oral Squamous Cell Carcinoma by Down-Regulating Dipeptidyl Peptidase 9 (DPP9). Onco Targets Ther. 2020;13:2599-2611 pubmed 出版商
Almoiliqy M, Wen J, Xu B, Sun Y, Lian M, Li Y, et al. Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin. 2020;41:1208-1222 pubmed 出版商
Wang J, Zhang Z, Li F, Chen J, Gong X, Cao B, et al. Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells. Oncol Rep. 2020;43:1863-1874 pubmed 出版商
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, et al. Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor. Redox Biol. 2020;32:101514 pubmed 出版商
Liu X, Zhang Y, Wu S, Xu M, Shen Y, Yu M, et al. Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA. Biochem Pharmacol. 2020;175:113933 pubmed 出版商
Lin L, Wang D, Qu S, Zhao H, Lin Y. miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition. Drug Des Devel Ther. 2020;14:1127-1141 pubmed 出版商
Wang J, Li G, Ming S, Wang C, Shi L, Su B, et al. BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses. PLoS Pathog. 2020;16:e1008429 pubmed 出版商
Zhang Y, Cui N, Zheng G. Ubiquitination of P53 by E3 ligase MKRN2 promotes melanoma cell proliferation. Oncol Lett. 2020;19:1975-1984 pubmed 出版商
Zhao Q, Zhu H, Xie X, Mao Q, Liu Y, He X, et al. Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways. Int J Mol Sci. 2020;21: pubmed 出版商
Zhu L, Dai L, Yang N, Liu M, Ma S, Li C, et al. Transcription factorIRX5 promotes hepatocellular carcinoma proliferation and inhibits apoptosis by regulating the p53 signalling pathway. Cell Biochem Funct. 2020;: pubmed 出版商
Dou Y, Huang D, Zeng X, Zhou Y, Jiang X, Yue C, et al. All-trans retinoic acid enhances the effect of Fra-1 to inhibit cell proliferation and metabolism in cervical cancer. Biotechnol Lett. 2020;42:1051-1060 pubmed 出版商
Yu X, Li H, Zhu M, Hu P, Liu X, Qing Y, et al. Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition. J Invest Dermatol. 2020;: pubmed 出版商
Tseng S, Park S, Lam B, Tsai Y, Cheng M, Farmer E, et al. Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis. J Immunother Cancer. 2020;8: pubmed 出版商
Liu H, Zhang W, Fang Y, Yang H, Tian L, Li K, et al. Neurotoxicity of aluminum oxide nanoparticles and their mechanistic role in dopaminergic neuron injury involving p53-related pathways. J Hazard Mater. 2020;392:122312 pubmed 出版商
Mao Y, Li W, Hua B, Gu X, Pan W, Chen Q, et al. Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells. Biomed Res Int. 2020;2020:2406159 pubmed 出版商
Shang Y, Wang Q, Li J, Zhao Q, Huang X, Dong H, et al. The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis. Onco Targets Ther. 2020;13:473-486 pubmed 出版商
Li D, Song J, Liang Z, Oskouei K, Xiao X, Hou W, et al. Apoptotic Effect of 1800 MHz Electromagnetic Radiation on NIH/3T3 Cells. Int J Environ Res Public Health. 2020;17: pubmed 出版商
Li Y, Chen F, Chen J, Chan S, He Y, Liu W, et al. Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways. Cancers (Basel). 2020;12: pubmed 出版商
Wang G, Sheng W, Tang J, Li X, Zhou J, Dong M. Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer. Biosci Rep. 2020;40: pubmed 出版商
Hou B, Li W, Li J, Ma J, Xia P, Liu Z, et al. Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway. Oncol Rep. 2020;43:536-548 pubmed 出版商
Lu W, Ma Y, Shao Q, Liang J, Qi T, Huang Y, et al. ROS/p53/miR‑335‑5p/Sp1 axis modulates the migration and epithelial to mesenchymal transition of JEG‑3 cells. Mol Med Rep. 2020;21:1208-1216 pubmed 出版商
Wang Q, Ren H, Xu Y, Jiang J, Wudu M, Liu Z, et al. GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway. Exp Cell Res. 2020;387:111806 pubmed 出版商
Li X, Yao Z, Yang D, Jiang X, Sun J, Tian L, et al. Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage. J Hazard Mater. 2020;387:121706 pubmed 出版商
Guo S, Jian L, Tao K, Chen C, Yu H, Liu S. Novel Breast-Specific Long Non-coding RNA LINC00993 Acts as a Tumor Suppressor in Triple-Negative Breast Cancer. Front Oncol. 2019;9:1325 pubmed 出版商
Wang S, Chen H, Tang L, Tu H, Liu B, Li N, et al. Upregulation of mitochondrial E3 ubiquitin ligase 1 in rat heart contributes to ischemia/reperfusion injury. Can J Physiol Pharmacol. 2019;: pubmed 出版商
Wu Z, Chen D, Wang K, Cao C, Xu X. Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma. Front Oncol. 2019;9:1260 pubmed 出版商
Lv X, Wang X, Wang Y, Zhou D, Li W, Wilson J, et al. Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism. Aging (Albany NY). 2019;11:10356-10373 pubmed 出版商
Li S, Hong X, Wei Z, Xie M, Li W, Liu G, et al. Ubiquitination of the HPV Oncoprotein E6 Is Critical for E6/E6AP-Mediated p53 Degradation. Front Microbiol. 2019;10:2483 pubmed 出版商
Liu L, Wang F, Tong Y, Li L, Liu Y, Gao W. Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction. Cell Prolif. 2019;:e12718 pubmed 出版商
Bai S, Zhu W, Coffman L, Vlad A, Schwartz L, Elishaev E, et al. CD105 Is Expressed in Ovarian Cancer Precursor Lesions and Is Required for Metastasis to the Ovary. Cancers (Basel). 2019;11: pubmed 出版商
Xu Y, Han X, Li Y, Min H, Zhao X, Zhang Y, et al. Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity. ACS Nano. 2019;13:13445-13455 pubmed 出版商
Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, et al. Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis. Cell Prolif. 2019;:e12706 pubmed 出版商
Hu Y, Ma S, Zhang X, Zhang Z, Zhu H, Ji Y, et al. Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression. Onco Targets Ther. 2019;12:8105-8115 pubmed 出版商
Liu X, Wu C, Han D, Liu J, Liu H, Jiang Z. Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats. Int J Mol Sci. 2019;20: pubmed 出版商
Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, et al. Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal. Front Pharmacol. 2019;10:1030 pubmed 出版商
Gao X, Zhang Y, Zhang R, Zhao Z, Zhang H, Wu J, et al. Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis. Exp Ther Med. 2019;18:3062-3070 pubmed 出版商
Liu X, Yang Y, Xu C, Yang H, Chen S, Chen H. RNA sequencing analysis of the CAL-27 cell response to over-expressed ZNF750 gene revealed an extensive regulation on cell cycle. Biomed Pharmacother. 2019;118:109377 pubmed 出版商
Pan J, Tang Y, Yu J, Zhang H, Zhang J, Wang C, et al. miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity. Cell Death Dis. 2019;10:668 pubmed 出版商
Guo Z, Tian Y, Guo Y, Li B, Liu X, Xie K, et al. RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration. Front Cell Neurosci. 2019;13:392 pubmed 出版商
Li Y, Shen R, Wu H, Yu L, Wang Z, Wang D. Liver changes induced by cadmium poisoning distinguished by confocal Raman imaging. Spectrochim Acta A Mol Biomol Spectrosc. 2019;225:117483 pubmed 出版商
Zhan S, Wang K, Song Y, Li S, Yin H, Luo R, et al. Long non-coding RNA HOTAIR modulates intervertebral disc degenerative changes via Wnt/β-catenin pathway. Arthritis Res Ther. 2019;21:201 pubmed 出版商
Li J, Jiang G, Zhao L, Yang F, Yuan W, Wang H, et al. Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression. Oncol Rep. 2019;: pubmed 出版商
Guo J, Wang Q, Zhang Y, Sun W, Zhang S, Li Y, et al. Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer. Pharmacol Res. 2019;147:104387 pubmed 出版商
Que Z, Zhou Z, Luo B, Dong C, Jiang Y, Li H, et al. Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells. BMC Complement Altern Med. 2019;19:204 pubmed 出版商
Liu X, Liu D, Lin G, Wu Y, Gao L, Ai C, et al. Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice. Int J Biol Macromol. 2019;139:342-351 pubmed 出版商
Liu M, Zhong J, Zeng Z, Huang K, Ye Z, Deng S, et al. Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein. Theranostics. 2019;9:4795-4810 pubmed 出版商
Saez I, Gerbracht J, Koyuncu S, Lee H, Horn M, Kroef V, et al. The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells. FEBS Lett. 2019;: pubmed 出版商
Cheng Y, Li J, Wang C, Yang H, Wang Y, Zhan T, et al. Inhibition of long non-coding RNA Malat1 attenuates high glucose-induced cardiomyocyte apoptosis via regulation of miR-181a-5p. Exp Anim. 2019;: pubmed 出版商
Xu J, Sheng Z, Li F, Wang S, Yuan Y, Wang M, et al. NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export. Exp Cell Res. 2019;:111505 pubmed 出版商
Fan X, Wang Y, Song J, Wu H, Yang M, Lu L, et al. MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma. Cancer Biol Ther. 2019;:1-9 pubmed 出版商
Yang J, Zeng Z, Qiao L, Jiang X, Ma J, Wang J, et al. Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer. Mol Cancer Res. 2019;: pubmed 出版商
Li X, Zhang T, Kamara M, Lu G, Xu H, Wang D, et al. Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity. Cell Death Dis. 2019;10:532 pubmed 出版商
Zhao W, Yan W, Chen D, Dai L, Yang Y, Kang X, et al. Genome-scale CRISPR activation screening identifies a role of ELAVL2-CDKN1A axis in paclitaxel resistance in esophageal squamous cell carcinoma. Am J Cancer Res. 2019;9:1183-1200 pubmed
Zhang L, Li F, Su X, Li Y, Wang Y, Fang R, et al. Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction. Exp Mol Med. 2019;51:73 pubmed 出版商
Gao Y, Yin H, Zhang Y, Dong Y, Yang F, Wu X, et al. Dexmedetomidine protects hippocampal neurons against hypoxia/reoxygenation-induced apoptosis through activation HIF-1α/p53 signaling. Life Sci. 2019;232:116611 pubmed 出版商
Liang M, Li H, Wang Z, Cai L, Yang L. Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats. J Sci Food Agric. 2019;: pubmed 出版商
Khan M, Zhao P, Khan A, Raza F, Raza S, Sarfraz M, et al. Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity. Int J Nanomedicine. 2019;14:3753-3771 pubmed 出版商
Gao J, Wang Y, Yang J, Zhang W, Meng K, Sun Y, et al. RNF128 Promotes Invasion and Metastasis Via the EGFR/MAPK/MMP-2 Pathway in Esophageal Squamous Cell Carcinoma. Cancers (Basel). 2019;11: pubmed 出版商
Hou S, Qu D, Li Y, Zhu B, Liang D, Wei X, et al. XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence. Nucleic Acids Res. 2019;47:8239-8254 pubmed 出版商
Wu G, Chen Z, Wang P, Zhao M, Fujino M, Zhang C, et al. Hydrogen inhalation protects hypoxic-ischemic brain damage by attenuating inflammation and apoptosis in neonatal rats. Exp Biol Med (Maywood). 2019;244:1017-1027 pubmed 出版商
Chen D, Zhao Y, Wang X, Liao W, Chen P, Deng K, et al. Regulatory factor X5 promotes hepatocellular carcinoma progression by transactivating tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta and suppressing apoptosis. Chin Med J (Engl). 2019;132:1572-1581 pubmed 出版商
Gao F, Liang Y, Zhou P, Cheng J, Ding K, Wang Y. Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin. Eur J Med Chem. 2019;178:177-194 pubmed 出版商
Lin Y, Liu B, Deng T, Zhong J, Feng Z, Zeng Q, et al. Normoxia is not favorable for maintaining stemness of human endothelial progenitor cells. Stem Cell Res. 2019;38:101464 pubmed 出版商
Luo X, Jiang X, Li J, Bai Y, Li Z, Wei P, et al. Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53-progerin interaction. Cell Death Dis. 2019;10:451 pubmed 出版商
Wang S, Wang W, Liu J, Song Y, Li P, Sun X, et al. Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide. Cell Cycle. 2019;18:1573-1587 pubmed 出版商
Tang S, Wang J, Liu J, Huang Y, Zhou Y, Yang S, et al. Niban protein regulates apoptosis in HK-2 cells via caspase-dependent pathway. Ren Fail. 2019;41:455-466 pubmed 出版商
Ren Y, Li Y, Lv J, Guo X, Zhang J, Zhou D, et al. Parthenolide regulates oxidative stress-induced mitophagy and suppresses apoptosis through p53 signaling pathway in C2C12 myoblasts. J Cell Biochem. 2019;120:15695-15708 pubmed 出版商
Wu X, Ansari A, Pang X, Li H, Zhang Z, Luo Y, et al. Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice. Arch Immunol Ther Exp (Warsz). 2019;: pubmed 出版商
Zhang W, Shao W, Dong Z, Zhang S, Liu C, Chen S. Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ. Cell Death Dis. 2019;10:404 pubmed 出版商
Yu W, Yang Z, Huang R, Min Z, Ye M. SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species. Onco Targets Ther. 2019;12:2861-2868 pubmed 出版商
Liu H, Zhao J, Fu R, Zhu C, Fan D. The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway. PLoS ONE. 2019;14:e0216759 pubmed 出版商
Yuan J, Yin Z, Tan L, Zhu W, Tao K, Wang G, et al. Interferon regulatory factor-1 reverses chemoresistance by downregulating the expression of P-glycoprotein in gastric cancer. Cancer Lett. 2019;457:28-39 pubmed 出版商
Huang Z, Li Q, Luo K, Zhang Q, Geng J, Zhou X, et al. miR-340-FHL2 axis inhibits cell growth and metastasis in ovarian cancer. Cell Death Dis. 2019;10:372 pubmed 出版商
Sun Z, Liu Y, Yu F, Xu Y, Yanli L, Liu N. Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline. Biomed Pharmacother. 2019;115:108933 pubmed 出版商
Guo D, Shen Y, Li W, Li Q, Zhao Y, Pan C, et al. 6-Bromoindirubin-3'-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver. Front Pharmacol. 2019;10:320 pubmed 出版商
Zhou X, Li W, Wang S, Zhang P, Wang Q, Xiao J, et al. YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis. Cell Rep. 2019;27:1176-1189.e5 pubmed 出版商
Feng X, Yan N, Sun W, Zheng S, Jiang S, Wang J, et al. miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways. Cell Death Discov. 2019;5:89 pubmed 出版商
Dong S, Ji J, Hu L, Wang H. Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration. Life Sci. 2019;227:20-29 pubmed 出版商
Lin F, Xie Y, Zhang X, Huang T, Xu H, Mei Y, et al. GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner. J Exp Clin Cancer Res. 2019;38:152 pubmed 出版商
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, et al. Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma. J Enzyme Inhib Med Chem. 2019;34:909-926 pubmed 出版商
Li E, Lin Q, Meng Y, Zhang L, Song P, Li N, et al. 2,4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K. Eur J Med Chem. 2019;172:36-47 pubmed 出版商
Fu R, Yang P, Sajid A, Li Z. Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth. J Agric Food Chem. 2019;67:4808-4816 pubmed 出版商
Xu S, Wu W, Huang H, Huang R, Xie L, Su A, et al. The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway. Aging Cell. 2019;18:e12918 pubmed 出版商
Bie Y, Gu P, Chen Y, Zhou X, Tian Y, Yang Q, et al. TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway. J Transl Med. 2019;17:72 pubmed 出版商
Sheng X, Zhou Y, Wang H, Shen Y, Liao Q, Rao Z, et al. Establishment and characterization of a radiation-induced dermatitis rat model. J Cell Mol Med. 2019;23:3178-3189 pubmed 出版商
Cao D, Qi Z, Pang Y, Li H, Xie H, Wu J, et al. Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer. Cancer Res. 2019;79:2604-2618 pubmed 出版商
Sun C, Nie J, Zheng Z, Zhao J, Wu L, Zhu Y, et al. Renoprotective effect of scutellarin on cisplatin-induced renal injury in mice: Impact on inflammation, apoptosis, and autophagy. Biomed Pharmacother. 2019;112:108647 pubmed 出版商
Chen X, Zeng K, Xu M, Liu X, Hu X, Xu T, et al. P53-induced miR-1249 inhibits tumor growth, metastasis, and angiogenesis by targeting VEGFA and HMGA2. Cell Death Dis. 2019;10:131 pubmed 出版商
Wudu M, Ren H, Hui L, Jiang J, Zhang S, Xu Y, et al. DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53. J Exp Clin Cancer Res. 2019;38:72 pubmed 出版商
Luo P, Wang Q, Ye Y, Zhang J, Lu D, Cheng L, et al. MiR-223-3p functions as a tumor suppressor in lung squamous cell carcinoma by miR-223-3p-mutant p53 regulatory feedback loop. J Exp Clin Cancer Res. 2019;38:74 pubmed 出版商
Gu X, Wang Z, Gao J, Han D, Zhang L, Chen P, et al. SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride. Toxicol In Vitro. 2019;57:28-38 pubmed 出版商
Wang G, Sheng W, Shi X, Li X, Zhou J, Dong M. Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53. FEBS J. 2019;286:1668-1682 pubmed 出版商
Mao Z, Han X, Chen D, Xu Y, Xu L, Yin L, et al. Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage. Br J Pharmacol. 2019;176:919-937 pubmed 出版商
Xu J, Liu H, Yang Y, Wang X, Liu P, Li Y, et al. Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1. MBio. 2019;10: pubmed 出版商
Negi H, Merugu S, Mangukiya H, Li Z, Zhou B, Sehar Q, et al. Anterior Gradient-2 monoclonal antibody inhibits lung cancer growth and metastasis by upregulating p53 pathway and without exerting any toxicological effects: A preclinical study. Cancer Lett. 2019;449:125-134 pubmed 出版商
Han Y, Wu P, Wang Z, Zhang Z, Sun S, Liu J, et al. Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation. EBioMedicine. 2019;40:92-105 pubmed 出版商
Yang J, Yu F, Guan J, Wang T, Liu C, Wang Y, et al. Knockdown of RNF2 enhances radiosensitivity of lung squamous cell carcinoma cells. Biochem Cell Biol. 2019;: pubmed 出版商
Li E, Sun Y, Lv G, Li Y, Zhang Z, Hu Z, et al. Sinoporphyrin sodium based sonodynamic therapy induces anti-tumor effects in hepatocellular carcinoma and activates p53/caspase 3 axis. Int J Biochem Cell Biol. 2019;: pubmed 出版商
Wang Y, Zhang J, Li J, Gui R, Nie X, Huang R. CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p. Bosn J Basic Med Sci. 2019;19:155-163 pubmed 出版商
Zhou Y, Niu W, Luo Y, Li H, Xie Y, Wang H, et al. The p53/LDHA axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53. Cancer Sci. 2019;: pubmed 出版商
Hou L, Zhang Y, Yang X, Tian C, Yan Y, Zhang H, et al. Intracellular NO-Generator Based on Enzyme Trigger for Localized Tumor-Cytoplasm Rapid Drug Release and Synergetic Cancer Therapy. ACS Appl Mater Interfaces. 2019;11:255-268 pubmed 出版商
Zhang X, Liu J, Gu Y, Sun C, Qu F. Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs. Cell Biol Int. 2019;43:158-166 pubmed 出版商
Shan H, Li T, Zhang L, Yang R, Li Y, Zhang M, et al. Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence. EBioMedicine. 2019;39:59-68 pubmed 出版商
Zheng D, Chang X, Liu Y, Xu J, Gou W, Li Z, et al. 2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol reverses EGF-induced cell migration and invasion through down-regulation of MDM2 in breast cancer cell lines. Cancer Biol Ther. 2019;20:513-523 pubmed 出版商
Xie Z, Guo Z, Lei J, Yu J. Scutellarin synergistically enhances cisplatin effect against ovarian cancer cells through enhancing the ability of cisplatin binding to DNA. Eur J Pharmacol. 2019;844:9-16 pubmed 出版商
Guo J, Tang Q, Wang Q, Sun W, Pu Z, Wang J, et al. Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells. Eur J Pharm Sci. 2019;128:61-72 pubmed 出版商
Liu H, Wu Q, Cao J, Wang X, Song Y, Mei W, et al. A phenanthroline derivative enhances radiosensitivity of hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis. Eur J Pharmacol. 2019;843:285-291 pubmed 出版商
Li S, Zhao X, Chang S, Li Y, Guo M, Guan Y. ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel. Int J Oncol. 2019;54:249-260 pubmed 出版商
Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, et al. PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis. Apoptosis. 2019;24:135-144 pubmed 出版商
Qu C, Ma J, Zhang Y, Han C, Huang L, Shen L, et al. Estrogen receptor variant ER-α36 promotes tamoxifen agonist activity in glioblastoma cells. Cancer Sci. 2019;110:221-234 pubmed 出版商
Pan J, Zhou H, Zhu S, Huang J, Zhao X, Ding H, et al. Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer. J Cell Physiol. 2019;234:4385-4395 pubmed 出版商
Sun Y, Liu W, Wang C, Meng Q, Liu Z, Huo X, et al. Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein. J Cell Physiol. 2019;234:3685-3696 pubmed 出版商
Daicheng H, Shiwen X, Huaping Z, Yong L, Qianqian Z, Changxia H. Fangchinoline Ameliorates the Expressions of Angiogenic Molecule in Cerebral Ischemia Induced Neuronal Degeneration in Neonatal Rats. Transl Neurosci. 2018;9:117-122 pubmed 出版商
Fang J, Zhu Y, Wang H, Cao B, Fei M, Niu W, et al. Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy. Front Neurosci. 2018;12:1006 pubmed 出版商
Sha J, Zhang H, Zhao Y, Feng X, Hu X, Wang C, et al. Dexmedetomidine attenuates lipopolysaccharide-induced liver oxidative stress and cell apoptosis in rats by increasing GSK-3β/MKP-1/Nrf2 pathway activity via the α2 adrenergic receptor. Toxicol Appl Pharmacol. 2018;364:144-152 pubmed 出版商
Liu B, Jin J, Zhang Z, Zuo L, Jiang M, Xie C. Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway. Biochem Cell Biol. 2018;:1-9 pubmed 出版商
Sui Y, Han Y, Zhao X, Li D, Li G. Long non-coding RNA GClnc1 promotes tumorigenesis in osteosarcoma by inhibiting p53 signaling. Biochem Biophys Res Commun. 2018;507:36-42 pubmed 出版商
Aratani S, Tagawa M, Nagasaka S, Sakai Y, Shimizu A, Tsuruoka S. Radiation-induced premature cellular senescence involved in glomerular diseases in rats. Sci Rep. 2018;8:16812 pubmed 出版商
Ding W, Ji T, Xiong W, Li T, Pu D, Liu R. Realgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway. Drug Des Devel Ther. 2018;12:3459-3469 pubmed 出版商
Brabetz S, Leary S, Gröbner S, Nakamoto M, Seker Cin H, Girard E, et al. A biobank of patient-derived pediatric brain tumor models. Nat Med. 2018;24:1752-1761 pubmed 出版商
Cheng B, Lu J, Li T, Meng Z, Liu M, Sun M, et al. 1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells. Food Chem Toxicol. 2018;122:143-150 pubmed 出版商
Liu L, Sun Y, Zhao Y, Wang Q, Guo H, Guo R, et al. Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis. Cancer Sci. 2018;109:3762-3773 pubmed 出版商
Zhu Y, Wang H, Fang J, Dai W, Zhou J, Wang X, et al. SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury. Oxid Med Cell Longev. 2018;2018:4783602 pubmed 出版商
Li Q, Pang P, Zheng K, Sun L, Wang J, Chen X. Xin-Jia-Xiang-Ru-Yin alleviated H1N1-induced acute lung injury and inhibited the IFN-γ-related regulatory pathway in summer flu. Biomed Pharmacother. 2018;108:201-207 pubmed 出版商
Zhang X, Wang K, Gao J, Li R, Guan Q, Song L. Study on the expression of p53 and MMP-2 in patients with lung cancer after interventional therapy. Oncol Lett. 2018;16:4291-4296 pubmed 出版商
Gao P, Wang X, Jin Y, Hu W, Duan Y, Shi A, et al. Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells. Breast Cancer Res. 2018;20:112 pubmed 出版商
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, et al. Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells. Mol Pharm. 2018;15:4974-4984 pubmed 出版商
Li H, Wang Z, Jiang M, Fang R, Shi H, Shen Y, et al. The oncoprotein HBXIP promotes human breast cancer growth through down-regulating p53 via miR-18b/MDM2 and pAKT/MDM2 pathways. Acta Pharmacol Sin. 2018;39:1787-1796 pubmed 出版商
Fu Y, Hong L, Xu J, Zhong G, Gu Q, Gu Q, et al. Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo. Autophagy. 2018;:1-17 pubmed 出版商
Zou G, Ren B, Liu Y, Fu Y, Chen P, Li X, et al. Inhibin B suppresses anoikis resistance and migration through the transforming growth factor-β signaling pathway in nasopharyngeal carcinoma. Cancer Sci. 2018;109:3416-3427 pubmed 出版商
Wang N, Zou C, Zhao S, Wang Y, Han C, Zheng Z. Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway. Invest Ophthalmol Vis Sci. 2018;59:4210-4217 pubmed 出版商
Meng X, Gao X, Zhang Z, Zhou X, Wu L, Yang M, et al. Protective effect and mechanism of rat recombinant S100 calcium-binding protein A4 on oxidative stress injury of rat vascular endothelial cells. Oncol Lett. 2018;16:3614-3622 pubmed 出版商
Ma J, Li X. Insight into the negative impact of ionic liquid: A cytotoxicity mechanism of 1-methyl-3-octylimidazolium bromide. Environ Pollut. 2018;242:1337-1345 pubmed 出版商
Hu M, Liu L, Yao W. Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells. Gene. 2018;678:261-269 pubmed 出版商
Song X, Liu Y, Shao J, Zhang Z, Xie C, Qiao X, et al. Rapid induction of apoptosis in tumor cells treated with a new platinum(II) complex based on amino-thiazolidinone. Eur J Med Chem. 2018;157:188-197 pubmed 出版商
Yang X, Qu S, Wang L, Zhang H, Yang Z, Wang J, et al. PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612. Oncogene. 2018;37:6399-6413 pubmed 出版商
Luo W, Wang Y, Yang H, Dai C, Hong H, Li J, et al. Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling. Aging (Albany NY). 2018;10:1722-1744 pubmed 出版商
Xie Z, Guo Z, Wang Y, Lei J, Yu J. Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy. Phytother Res. 2018;32:2256-2263 pubmed 出版商
Zhang Y, Wang C, Jin Y, Yang Q, Meng Q, Liu Q, et al. Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link. Oxid Med Cell Longev. 2018;2018:2876350 pubmed 出版商
Pei S, Huang J, Chen J, Hu S, Lei L, Fu C, et al. UVB-inhibited H19 activates melanogenesis by paracrine effects. Exp Dermatol. 2018;27:1120-1125 pubmed 出版商
Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, et al. DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling. Cell Res. 2018;28:833-854 pubmed 出版商
Liu S, Gao X, Zhang L, Qin S, Wei M, Liu N, et al. A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/?-catenin signaling pathway. Eur J Med Chem. 2018;156:21-42 pubmed 出版商
Yang H, Hong H, Luo W, Dai C, Chen X, Wang L, et al. mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway. Acta Pharmacol Sin. 2018;39:1837-1846 pubmed 出版商
Li W, Liu J, Fu W, Zheng X, Ren L, Liu S, et al. 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase. J Exp Clin Cancer Res. 2018;37:132 pubmed 出版商
Yang T, Cheng J, You J, Yan B, Liu H, Li F. S100B promotes chemoresistance in ovarian cancer stem cells by regulating p53. Oncol Rep. 2018;40:1574-1582 pubmed 出版商
Li Y, Peng Z, Wang C, Li L, Leng Y, Chen R, et al. Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence. Am J Physiol Heart Circ Physiol. 2018;315:H571-H580 pubmed 出版商
Jiang Y, Dong G, Song Y. Nucleus pulposus cell senescence is alleviated by resveratrol through regulating the ROS/NF-κB pathway under high-magnitude compression. Biosci Rep. 2018;38: pubmed 出版商
Liu X, Zhao Y, Zhang W, Gao Y, Huo M, Liu M, et al. Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis. Onco Targets Ther. 2018;11:3087-3100 pubmed 出版商
Ling Z, Guan H, You Z, Wang C, Hu L, Zhang L, et al. Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo. Onco Targets Ther. 2018;11:2735-2743 pubmed 出版商
Hou G, Zhao H, Teng H, Li P, Xu W, Zhang J, et al. N-Cadherin Attenuates High Glucose-Induced Nucleus Pulposus Cell Senescence Through Regulation of the ROS/NF-κB Pathway. Cell Physiol Biochem. 2018;47:257-265 pubmed 出版商
Wang X, Su G, Zhao C, Qu F, Wang P, Zhao Y. Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells. J Ginseng Res. 2018;42:133-143 pubmed 出版商
Guo P, Qiu Y, Ma X, Li T, Ma X, Zhu L, et al. Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis. Exp Cell Res. 2018;368:59-66 pubmed 出版商
Chen L, Yan F, Chen W, Zhao L, Zhang J, Lu Q, et al. Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cells DU145. Chem Biol Interact. 2018;288:12-23 pubmed 出版商
Jia W, Jiang X, Liu W, Wang L, Zhu B, Zhu H, et al. Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells. Int J Oncol. 2018;52:1787-1800 pubmed 出版商
Tang X, Liu B, Wang X, Yu Q, Fang R. Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis. Int J Mol Sci. 2018;19: pubmed 出版商
Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, et al. Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer. Cancer Med. 2018;7:1546-1559 pubmed 出版商
Wang H, Zhong Q, Yang T, Qi Y, Fu M, Yang X, et al. Comparative characterization of SHED and DPSCs during extended cultivation in vitro. Mol Med Rep. 2018;17:6551-6559 pubmed 出版商
Wang Z, Chen L, Qiu Z, Chen X, Liu Y, Li J, et al. Ginsenoside Rg1 ameliorates testicular senescence changes in D‑gal‑induced aging mice via anti‑inflammatory and antioxidative mechanisms. Mol Med Rep. 2018;17:6269-6276 pubmed 出版商
Gao M, Chen M, Li C, Xu M, Liu Y, Cong M, et al. Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress. Cell Discov. 2018;4:5 pubmed 出版商
Zhang T, Wang P, Liu Y, Zhou J, Shi Z, Cheng K, et al. Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo. Cell Tissue Res. 2018;373:379-393 pubmed 出版商
Cui Q, Kong D, Li Z, Ahiable P, Wang K, Wu K, et al. Dachshund 1 is Differentially Expressed Between Male and Female Breast Cancer: A Matched Case-Control Study of Clinical Characteristics and Prognosis. Clin Breast Cancer. 2018;18:e875-e882 pubmed 出版商
Li L, Peng J, Zhou W, Qiao H, Deng X, Li Z, et al. Potent hydrazone derivatives targeting esophageal cancer cells. Eur J Med Chem. 2018;148:359-371 pubmed 出版商
Lin C, Zhang J, Lu Y, Li X, Zhang W, Zhang W, et al. NIT1 suppresses tumour proliferation by activating the TGFβ1-Smad2/3 signalling pathway in colorectal cancer. Cell Death Dis. 2018;9:263 pubmed 出版商
Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, et al. MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development. J Exp Clin Cancer Res. 2018;37:28 pubmed 出版商
Zhang J, Yuan J, Wang Q, Shao L, Liu S, Firestone R, et al. Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer. Oncotarget. 2018;9:1957-1968 pubmed 出版商
Li C, Sun J, Gao Y, Shi F, Pan Y, Wang Y, et al. Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells. Cell Death Dis. 2018;9:147 pubmed 出版商
Ruan W, Zhao F, Zhao S, Zhang L, Shi L, Pang T. Knockdown of long noncoding RNA MEG3 impairs VEGF-stimulated endothelial sprouting angiogenesis via modulating VEGFR2 expression in human umbilical vein endothelial cells. Gene. 2018;649:32-39 pubmed 出版商
Jin Y, Hu W, Liu T, Rana U, Aguilera Barrantes I, Kong A, et al. Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel. Cancer Lett. 2018;419:233-244 pubmed 出版商
Shen H, Zhan M, Zhang Y, Huang S, Xu S, Huang X, et al. PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2. Cell Death Dis. 2018;9:71 pubmed 出版商
Zhang Z, Zhang H, Zhang Q, Lai S, Feng Y, Zhou Y, et al. High expression of TMEM40 is associated with the malignant behavior and tumorigenesis in bladder cancer. J Transl Med. 2018;16:9 pubmed 出版商
Liu D, Cheng Y, Cai R, Wang Bd W, Cui H, Liu M, et al. The enhancement of siPLK1 penetration across BBB and its anti glioblastoma activity in vivo by magnet and transferrin co-modified nanoparticle. Nanomedicine. 2018;14:991-1003 pubmed 出版商
Welcker D, Jain M, Khurshid S, Jokic M, Höhne M, Schmitt A, et al. AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer. Oncogene. 2018;37:1503-1518 pubmed 出版商
Zhou P, Liang Y, Zhang H, Jiang H, Feng K, Xu P, et al. Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents. Eur J Med Chem. 2018;144:817-842 pubmed 出版商
Zhang W, Yao F, Zhang H, Li N, Zou X, Sui L, et al. The Potential Roles of the Apoptosis-Related Protein PDRG1 in Diapause Embryo Restarting of Artemia sinica. Int J Mol Sci. 2018;19: pubmed 出版商
Hao B, Xiao Y, Song F, Long X, Huang J, Tian M, et al. Metformin-induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16. Int J Mol Med. 2018;41:1365-1376 pubmed 出版商
Niu M, Ma F, Qian J, Li J, Wang T, Gao Y, et al. N?cadherin attenuates nucleus pulposus cell senescence under high?magnitude compression. Mol Med Rep. 2018;17:2879-2884 pubmed 出版商
Ma J, Li Y, Wu M, Li X. Oxidative stress-mediated p53/p21WAF1/CIP1 pathway may be involved in microcystin-LR-induced cytotoxicity in HepG2 cells. Chemosphere. 2018;194:773-783 pubmed 出版商
Zhang J, Zhang Y, Peng J, Li N, Xiong X, Ma Q, et al. Atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats through a mechanism involving down-regulation of miR-21-5p/203a-3p. Mech Ageing Dev. 2018;169:10-18 pubmed 出版商
Guo X, Deng X, Wei Y. Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation. Stem Cells. 2018;36:406-419 pubmed 出版商
Liu L, Zhang L, Wang J, Zhao X, Xu Q, Lu Y, et al. Downregulation of TRIM28 inhibits growth and increases apoptosis of nude mice with non?small cell lung cancer xenografts. Mol Med Rep. 2018;17:835-842 pubmed 出版商
Ma D, Chen X, Zhang P, Zhang H, Wei L, Hu S, et al. Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth. Oncogene. 2018;37:1041-1048 pubmed 出版商
Ai T, Sun J, Du L, Shi C, Li C, Sun X, et al. Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62. Cell Death Differ. 2018;25:319-329 pubmed 出版商
Zhu X, Wang K, Yao Y, Zhang K, Zhou F, Zhu L. Triggering p53 activation is essential in ziyuglycoside I-induced human retinoblastoma WERI-Rb-1 cell apoptosis. J Biochem Mol Toxicol. 2018;32: pubmed 出版商
Wang W, Cai G, Chen X. Dietary restriction delays the secretion of senescence associated secretory phenotype by reducing DNA damage response in the process of renal aging. Exp Gerontol. 2018;107:4-10 pubmed 出版商
Sun Y, Wang C, Meng Q, Liu Z, Huo X, Sun P, et al. Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca2+ -mediated apoptosis pathways in MCF-7/ADR and K562/ADR. J Cell Physiol. 2018;233:3066-3079 pubmed 出版商
Yin S, Du W, Wang F, Han B, Cui Y, Yang D, et al. MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway. Cancer Biol Ther. 2018;19:260-270 pubmed 出版商
Ren G, Hu J, Shang Y, Zhong Y, Yu Z, An J. Tributylphosphate (TBP) and tris (2-butoxyethyl) phosphate (TBEP) induced apoptosis and cell cycle arrest in HepG2 cells. Toxicol Res (Camb). 2017;6:902-911 pubmed 出版商
Deng X, Song L, Zhao W, Wei Y, Guo X. HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway. Front Cell Neurosci. 2017;11:420 pubmed 出版商
Zhao W, Lu D, Liu L, Cai J, Zhou Y, Yang Y, et al. Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability. Oncotarget. 2017;8:93672-93687 pubmed 出版商
Duan H, Wang R, Yan X, Liu H, Zhang Y, Mu D, et al. Phloretin induces apoptosis of human esophageal cancer via a mitochondria-dependent pathway. Oncol Lett. 2017;14:6763-6768 pubmed 出版商
Zhang M, Liang Y, Li H, Liu M, Wang Y. Design, synthesis, and biological evaluation of hydantoin bridged analogues of combretastatin A-4 as potential anticancer agents. Bioorg Med Chem. 2017;25:6623-6634 pubmed 出版商
Ding Z, Jiao X, Wu D, Zhang J, Chen F, Wang Y, et al. Bisphenol AF negatively affects oocyte maturation of mouse in vitro through increasing oxidative stress and DNA damage. Chem Biol Interact. 2017;278:222-229 pubmed 出版商
Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J. Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver. Plant Foods Hum Nutr. 2017;72:425-431 pubmed 出版商
Hu D, Cao S, Zhang G, Xiao Y, Liu S, Shang Y. Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts. Sci Rep. 2017;7:13554 pubmed 出版商
Liu L, Zhang P, Guo H, Tang X, Liu L, Li J, et al. Co?expression of murine double minute 2 siRNA and wild?type p53 induces G1 cell cycle arrest in H1299 cells. Mol Med Rep. 2017;16:9137-9142 pubmed 出版商
Gao M, Huang Y, Wang L, Huang M, Liu F, Liao S, et al. HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators. Cell Death Dis. 2017;8:e3082 pubmed 出版商
Li X, Jiang Z, Feng J, Zhang X, Wu J, Chen W. 2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G2/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer. Oncotarget. 2017;8:61846-61860 pubmed 出版商
Li S, Zhao H, Wang Y, Shao Y, Li J, Liu J, et al. The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart. Chemosphere. 2017;189:489-497 pubmed 出版商
Cai X, Cao C, Li J, Chen F, Zhang S, Liu B, et al. Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1. Oncotarget. 2017;8:58338-58352 pubmed 出版商
Wang H, Zhu L, Feng X, Zhang H, Luo Q, Chen F. Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma. Eur J Pharmacol. 2017;815:282-289 pubmed 出版商
Drosos Y, Escobar D, Chiang M, Roys K, Valentine V, Valentine M, et al. ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer. Sci Rep. 2017;7:11144 pubmed 出版商
Lei C, Tang H, Ye C, You C, Zhang J, Zhang C, et al. MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1. Sci Rep. 2017;7:10393 pubmed 出版商
Alessio N, Capasso S, Ferone A, Di Bernardo G, Cipollaro M, Casale F, et al. Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence. Neoplasia. 2017;19:781-790 pubmed 出版商
Tang Q, Ji F, Wang J, Guo L, Li Y, Bao Y. Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin. Eur J Pharm Sci. 2017;109:223-232 pubmed 出版商
Chen Z, Liu J, Zhang Y. Role of Epithelial Cell Transforming Sequence 2 (ECT2) in Predicting Prognosis of Osteosarcoma. Med Sci Monit. 2017;23:3861-3868 pubmed
Tang H, Yao X, Yao C, Zhao X, Zuo H, Li Z. Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites. Sci Rep. 2017;7:7599 pubmed 出版商
Pan Y, Zhang F, Zhao Y, Shao D, Zheng X, Chen Y, et al. Berberine Enhances Chemosensitivity and Induces Apoptosis Through Dose-orchestrated AMPK Signaling in Breast Cancer. J Cancer. 2017;8:1679-1689 pubmed 出版商
Ye J, Wei X, Shang Y, Pan Q, Yang M, Tian Y, et al. Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity. Oncogene. 2017;36:6391-6407 pubmed 出版商
Xia C, Shui L, Lou G, Ye B, Zhu W, Wang J, et al. 0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop. Sci Rep. 2017;7:4396 pubmed 出版商
Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, et al. Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain. J Agric Food Chem. 2017;65:5973-5984 pubmed 出版商
Pan Y, Shao D, Zhao Y, Zhang F, Zheng X, Tan Y, et al. Berberine Reverses Hypoxia-induced Chemoresistance in Breast Cancer through the Inhibition of AMPK- HIF-1α. Int J Biol Sci. 2017;13:794-803 pubmed 出版商
Ma X, Jiang C, Li Y, Feng L, Liu J, Wang J. Inhibition effect of tacrolimus and platelet-derived growth factor-BB on restenosis after vascular intimal injury. Biomed Pharmacother. 2017;93:180-189 pubmed 出版商
Su W, Lin Y, Yu X, Wang Y, Lin X, Su Q, et al. Mitochondria-Associated Apoptosis in Human Melanoma Cells Induced by Cardanol Monoene from Cashew Nut Shell Liquid. J Agric Food Chem. 2017;65:5620-5631 pubmed 出版商
Zhai Y, Wu R, Kuick R, Sessine M, Schulman S, Green M, et al. High-grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease. J Pathol. 2017;243:16-25 pubmed 出版商
Ren Y, Li Y, Yan J, Ma M, Zhou D, Xue Z, et al. Adiponectin modulates oxidative stress-induced mitophagy and protects C2C12 myoblasts against apoptosis. Sci Rep. 2017;7:3209 pubmed 出版商
Hu T, Yang C, Fu M, Yang J, Du R, Ran X, et al. Cytotoxic effects of docetaxel as a candidate drug of drug-eluting stent on human umbilical vein endothelial cells and the signaling pathway of cell migration inhibition, adhesion delay and shape change. Regen Biomater. 2017;4:167-178 pubmed 出版商
Lu Q, Zhuang J, Guo H. Renal cell carcinoma with synchronous ipsilateral urothelial carcinoma of the renal pelvis. Oncol Lett. 2017;13:4521-4525 pubmed 出版商
Smith S, Mellor P, Ward A, Kendall S, McDonald M, Vizeacoumar F, et al. Molecular characterization of breast cancer cell lines through multiple omic approaches. Breast Cancer Res. 2017;19:65 pubmed 出版商
Wu W, Hou C, Mu X, Sun C, Zhu Y, Wang M, et al. H2S Donor NaHS Changes the Production of Endogenous H2S and NO in D-Galactose-Induced Accelerated Ageing. Oxid Med Cell Longev. 2017;2017:5707830 pubmed 出版商
Wang X, Zhang X, Wang G, Wang L, Lin Y, Sun F. Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells. Gene. 2017;626:344-353 pubmed 出版商
Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, et al. The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis. Oncotarget. 2017;8:47250-47268 pubmed 出版商
Yao C, Cao X, Fu Z, Tian J, Dong W, Xu J, et al. Boschniakia Rossica Polysaccharide Triggers Laryngeal Carcinoma Cell Apoptosis by Regulating Expression of Bcl-2, Caspase-3, and P53. Med Sci Monit. 2017;23:2059-2064 pubmed
Jiang H, Guo S, Xiao D, Bian X, Wang J, Wang Y, et al. Arginine deiminase expressed in vivo, driven by human telomerase reverse transcriptase promoter, displays high hepatoma targeting and oncolytic efficiency. Oncotarget. 2017;8:37694-37704 pubmed 出版商
Wang Q, Ding W, Ding Y, Ma J, Qian Z, Shao J, et al. Homoharringtonine suppresses imatinib resistance via the Bcl-6/p53 pathway in chronic myeloid leukemia cell lines. Oncotarget. 2017;8:37594-37604 pubmed 出版商
Liu L, Liu Y, Chen X, Wang M, Zhou Y, Zhou P, et al. Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma. Oncotarget. 2017;8:43990-44003 pubmed 出版商
Liu Y, Tang Q, Shao S, Chen Y, Chen W, Xu X. Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells. Int J Biol Sci. 2017;13:327-338 pubmed 出版商
Lu C, Lee C, Tseng C, Tarn W. Y14 governs p53 expression and modulates DNA damage sensitivity. Sci Rep. 2017;7:45558 pubmed 出版商
Wang Y, Xiao H, Wu H, Yao C, He H, Wang C, et al. G protein subunit ? q regulates gastric cancer growth via the p53/p21 and MEK/ERK pathways. Oncol Rep. 2017;37:1998-2006 pubmed 出版商
Zhang J, Liu W, Peng J, Ma Q, Peng J, Luo X. miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1. Mech Ageing Dev. 2017;164:8-19 pubmed 出版商
Shen Y, Liu S, Fan J, Jin Y, Tian B, Zheng X, et al. Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions. EMBO Rep. 2017;18:536-548 pubmed 出版商
Wang H, Xu Y, Wang M, Cheng C, Bian R, Yuan H, et al. Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders. Int J Mol Med. 2017;39:819-830 pubmed 出版商
Shi L, Song R, Yao X, Ren Y. Effects of selenium on the proliferation, apoptosis and testosterone production of sheep Leydig cells in vitro. Theriogenology. 2017;93:24-32 pubmed 出版商
Li P, Gan Y, Xu Y, Wang L, Ouyang B, Zhang C, et al. 17beta-estradiol Attenuates TNF-?-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/NF-?B Pathway. Int J Biol Sci. 2017;13:145-156 pubmed 出版商
Li Z, Guo G, Wang H, Si X, Zhou G, Xiong Y, et al. TRPC5 channel modulates endothelial cells senescence. Eur J Pharmacol. 2017;802:27-35 pubmed 出版商
Li P, Gan Y, Xu Y, Song L, Wang L, Ouyang B, et al. The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway. Sci Rep. 2017;7:42938 pubmed 出版商
Zhang M, Yao F, Qin T, Hou L, Zou X. Identification, expression pattern and functional characterization of As-kip2 in diapause embryo restarting process of Artemia sinica. Gene. 2017;608:28-40 pubmed 出版商
Mao X, Li P, Wang Y, Liang Z, Liu J, Li J, et al. CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells. Cell Death Dis. 2017;8:e2546 pubmed 出版商
Yin Y, Zhou Z, Liu W, Chang Q, Sun G, Dai Y. Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway. Int J Biochem Cell Biol. 2017;84:22-34 pubmed 出版商
Ye Q, Pang S, Zhang W, Guo X, Wang J, Zhang Y, et al. Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia. Arterioscler Thromb Vasc Biol. 2017;37:476-484 pubmed 出版商
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, et al. Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin. Oncotarget. 2017;8:8622-8632 pubmed 出版商
Zhou M, Chen F, Chen H, Wan X, Zhou X, Fang Q, et al. ISG15 inhibits cancer cell growth and promotes apoptosis. Int J Mol Med. 2017;39:446-452 pubmed 出版商
Wang X, Sun Y, Zhao C, Qu F, Zhao Y. 12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis. Eur J Pharmacol. 2017;798:49-56 pubmed 出版商
Song X, Shi Q, Liu Z, Wang Y, Wang Y, Song E, et al. Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone. Chem Res Toxicol. 2016;29:2184-2193 pubmed
Yang J, Qiao L, Zeng Z, Wang J, Zhu T, Wei J, et al. The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD. Toxicol Lett. 2017;265:131-139 pubmed 出版商
Tang Q, Ji F, Sun W, Wang J, Guo J, Guo L, et al. Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects. Phytomedicine. 2016;23:1778-1786 pubmed 出版商
Zhou Z, Yin Y, Chang Q, Sun G, Lin J, Dai Y. Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells. Cell Prolif. 2017;50: pubmed 出版商
Zhao S, Li L, Wang S, Yu C, Xiao B, Lin L, et al. H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway. Oncotarget. 2016;7:84839-84850 pubmed 出版商
Wu H, Yang P, Hu W, Wang Y, Lu Y, Zhang L, et al. Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability. Oncotarget. 2016;7:78069-78082 pubmed 出版商
Chen L, Lv D, Wang D, Chen X, Zhu Z, Cao Y, et al. A novel strategy of profiling the mechanism of herbal medicines by combining network pharmacology with plasma concentration determination and affinity constant measurement. Mol Biosyst. 2016;12:3347-3356 pubmed
Wang Y, Zhang X, Xie W, Zheng Y, Cao J, Cao P, et al. The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression. Nutrients. 2016;8: pubmed
Zu G, Yao J, Ji A, Ning S, Luo F, Li Z, et al. Nurr1 promotes intestinal regeneration after ischemia/reperfusion injury by inhibiting the expression of p21 (Waf1/Cip1). J Mol Med (Berl). 2017;95:83-95 pubmed 出版商
Yang T, Cheng J, Yang Y, Qi W, Zhao Y, Long H, et al. S100B Mediates Stemness of Ovarian Cancer Stem-Like Cells Through Inhibiting p53. Stem Cells. 2017;35:325-336 pubmed 出版商
Tang Q, Ji F, Guo J, Wang J, Li Y, Bao Y. Directional modification of chrysin for exerting apoptosis and enhancing significantly anti-cancer effects of 10-hydroxy camptothecin. Biomed Pharmacother. 2016;82:693-703 pubmed 出版商
Gamallat Y, Meyiah A, Kuugbee E, Hago A, Chiwala G, Awadasseid A, et al. Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model. Biomed Pharmacother. 2016;83:536-541 pubmed 出版商
Yuan S, Wen J, Cheng J, Shen W, Zhou S, Yan W, et al. Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway. Cell Cycle. 2016;15:2895-2905 pubmed
Huang C, Lei K, Tsang N. Paper-based microreactor array for rapid screening of cell signaling cascades. Lab Chip. 2016;16:2911-20 pubmed 出版商
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, et al. Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation. Environ Toxicol Pharmacol. 2016;45:193-201 pubmed 出版商
Hu Y, Wu S, Zhao J, Ma X, Lu J, Xiu J, et al. VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet. J Lipid Res. 2016;57:1398-411 pubmed 出版商
Zhao X, Tao X, Xu L, Yin L, Qi Y, Xu Y, et al. Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. Molecules. 2016;21: pubmed 出版商
Du J, Cong B, Yu Q, Wang H, Wang L, Wang C, et al. Upregulation of microRNA-22 contributes to myocardial ischemia-reperfusion injury by interfering with the mitochondrial function. Free Radic Biol Med. 2016;96:406-17 pubmed 出版商
Lu Y, Wang J, Dapeng C, Wu D, Cai G, Chen X. Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells. BMC Nephrol. 2016;17:39 pubmed 出版商
Hua X, Lu T, Zhang J, Miao Q, Bian Z, Zhang H, et al. Hypoxia-inducible factor-2? promotes hepatocyte apoptosis during cholestasis. Hepatol Res. 2017;47:95-102 pubmed 出版商
Hu K, Tian Y, Du Y, Huang L, Chen J, Li N, et al. Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling. Int J Oncol. 2016;48:2166-74 pubmed 出版商
Wang G, Yao J, Li Z, Zu G, Feng D, Shan W, et al. miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling. Antioxid Redox Signal. 2016;24:961-73 pubmed 出版商
Si L, Zheng L, Xu L, Yin L, Han X, Qi Y, et al. Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion. Eur J Pharmacol. 2016;774:105-17 pubmed 出版商
Dong C, Zhao B, Long F, Liu Y, Liu Z, Li S, et al. Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein. Oncotarget. 2016;7:8850-65 pubmed 出版商
Inoue K, Tsubamoto H, Sakata K, Sakane R, Hao H, Hirota S, et al. Expression of Hedgehog Signals and Growth Inhibition by Itraconazole in Endometrial Cancer. Anticancer Res. 2016;36:149-53 pubmed
Zhan W, Han T, Zhang C, Xie C, Gan M, Deng K, et al. TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins. PLoS ONE. 2015;10:e0142596 pubmed 出版商
Ying Q, Ansong E, Diamond A, Yang W. A Critical Role for Cysteine 57 in the Biological Functions of Selenium Binding Protein-1. Int J Mol Sci. 2015;16:27599-608 pubmed 出版商
Yu J, Ren P, Zhong T, Wang Y, Yan M, Xue B, et al. Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma. Mol Med Rep. 2015;12:7195-202 pubmed 出版商
Yang Y, Jiang L, She Y, Chen M, Li Q, Yang G, et al. Olaquindox induces DNA damage via the lysosomal and mitochondrial pathway involving ROS production and p53 activation in HEK293 cells. Environ Toxicol Pharmacol. 2015;40:792-9 pubmed 出版商
Song X, Li L, Shi Q, Lehmler H, Fu J, Su C, et al. Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells. Chem Res Toxicol. 2015;28:2160-9 pubmed 出版商
Zhang H, Jiang S, Zhang X, Zhou Z, Pan Q, Chen C, et al. Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma. Oncotarget. 2015;6:34800-17 pubmed 出版商
Yuan H, Wang J, Wang F, Zhang N, Li Q, Xie F, et al. Mucin 1 gene silencing inhibits the growth of SMMC-7721 human hepatoma cells through Bax-mediated mitochondrial and caspase-8-mediated death receptor apoptotic pathways. Mol Med Rep. 2015;12:6782-8 pubmed 出版商
Lu Y, Wen J, Chen D, Wu L, Li Q, Xie Y, et al. Modulation of cyclins and p53 in mesangial cell proliferation and apoptosis during Habu nephritis. Clin Exp Nephrol. 2016;20:178-86 pubmed 出版商
Liu F, Zhang W, You X, Liu Y, Li Y, Wang Z, et al. The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer. Oncotarget. 2015;6:27199-213 pubmed 出版商
Li H, Liu Q, Wang Z, Fang R, Shen Y, Cai X, et al. The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer. J Biol Chem. 2015;290:22649-61 pubmed 出版商
Li P, Zhao M, Parris A, Feng X, Yang X. p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2015;464:1267-74 pubmed 出版商
Liu J, Huang W, Ren C, Wen Q, Liu W, Yang X, et al. Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways. Sci Rep. 2015;5:11614 pubmed 出版商
Zheng H, Fu Y, Pan Z, Yang T, Sun L, Chen Y, et al. The effect of mesenchymal stem cells on the p53 methylation in irradiation-induced thymoma in C57BL/6 mice. J Cancer Res Ther. 2015;11:403-8 pubmed 出版商
Jin Y, Cao B, Zhang M, Zhan Q, Herman J, Yu M, et al. RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker. Genes Cancer. 2015;6:231-40 pubmed
Wang X, Han L, Zhang J, Xia Q. Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma. Dig Dis Sci. 2015;60:3011-8 pubmed 出版商
Sun S, Cheng B, Sun P, Wu X, Wu Q, He P. RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation. Exp Biol Med (Maywood). 2015;240:1606-13 pubmed 出版商
Gu Y, He Y, Zhang X, Shi Y, Yang Q, Yu L, et al. Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice. Mol Reprod Dev. 2015;82:475-88 pubmed 出版商
Huang M, Li D, Huang Y, Cui X, Liao S, Wang J, et al. HSF4 promotes G1/S arrest in human lens epithelial cells by stabilizing p53. Biochim Biophys Acta. 2015;1853:1808-17 pubmed 出版商
Dong H, Shi Q, Song X, Fu J, Hu L, Xu D, et al. Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis. Toxicol Appl Pharmacol. 2015;286:10-6 pubmed 出版商
Dan J, Sun X, Li W, Zhang Y, Li X, Xu H, et al. 5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Promotes Phenotypic Switching from Dedifferentiated to Differentiated Phenotype via Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase in Vascular Smooth Muscle Cells. Ultrasound Med Biol. 2015;41:1681-9 pubmed 出版商
Zhang X, Pan Q, Pan K, Weng D, Wang Q, Zhao J, et al. Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma. Mol Carcinog. 2016;55:64-76 pubmed 出版商
Mei L, Chen Y, Wang Z, Wang J, Wan J, Yu C, et al. Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21. Br J Pharmacol. 2015;172:2232-45 pubmed 出版商
Hu Z, Ding W, Zhu D, Yu L, Jiang X, Wang X, et al. TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy. J Clin Invest. 2015;125:425-36 pubmed 出版商
Zhu D, Yuan Y, Qiao J, Yu C, Yang X, Wang L, et al. Enhanced anticancer activity of a protein phosphatase 2A inhibitor on chemotherapy and radiation in head and neck squamous cell carcinoma. Cancer Lett. 2015;356:773-80 pubmed 出版商
Li X, Liu X, Xu Y, He Y, Liu J, Xie M. Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins. Int J Oncol. 2015;46:677-84 pubmed 出版商
Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, et al. Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo. Int J Oncol. 2015;46:360-8 pubmed 出版商
目录号 :
AntigenName :
Package :
价格 :
Exsists20ul :
20ul trial size available
FullName :
免疫原 :
物种 :
artemia, artemia sinica, human, mouse, pig, rat, sheep, swine
宿主 :
IsConjugated :
AntigenSpecies :
应用 :
免疫印迹, 免疫沉淀, IF, CoIP, chIP, 酶联免疫吸附测定
Clonlity :
抗体亚型 :
同义词 :
Antigen NY CO 13, Cellular tumor antigen p53, LFS1, P53, Phosphoprotein p53, TP53, TRP53, tumor protein p53, Tumor suppressor p53
PrimaryOrSecondary :
抗体缓冲液 :
PBS含0.1%叠氮化钠和50% 甘油pH值7.3
GenBank登录号 :
类别 :
Apoptosis;Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Disease Related;IVD;Metabolism;Neurology;Oncogene(s) and Tumor Suppressor(s);Senescence;
PurifyMethod :
NewAb :
IsSellable :
Feature :
AppTiter :
IF 1:50;免疫沉淀1:1000;免疫印迹1:3000;
4006 900 926, 027-87531629 / 027-87531627
公司总部: 美国
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