Yang Y, Chen S, Tao L, Gan S, Luo H, Xu Y, et al. Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro. Med Sci Monit. 2019;25:5375-5388 pubmed 出版商

Hos N, Ganesan R, Gutierrez S, Hos D, Klimek J, Abdullah Z, et al. Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses. J Cell Biol. 2017;216:4107-4121 pubmed 出版商

Ugun Klusek A, Tatham M, Elkharaz J, Constantin Teodosiu D, Lawler K, Mohamed H, et al. Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway. Cell Death Dis. 2017;8:e2531 pubmed 出版商

Park S, Han S, Choi I, Kim B, Park S, Joe E, et al. Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy. PLoS ONE. 2016;11:e0163029 pubmed 出版商

Tian Y, Wu K, Liu Q, Han N, Zhang L, Chu Q, et al. Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer. J Hematol Oncol. 2016;9:83 pubmed 出版商

Sakurai T, Isogaya K, Sakai S, Morikawa M, Morishita Y, Ehata S, et al. RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma. Oncogene. 2016;35:5000-9 pubmed 出版商

Sun B, Wang X, Liu X, Wang L, Ren F, Wang X, et al. Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease. Antioxidants (Basel). 2020;9: pubmed 出版商

Wang T, Jian Z, Baskys A, Yang J, Li J, Guo H, et al. MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system. Biomaterials. 2020;257:120264 pubmed 出版商

Lu Y, Sun Y, Liu Z, Lu Y, Zhu X, Lan B, et al. Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease. Sci Transl Med. 2020;12: pubmed 出版商

Liu J, Hu Y, Feng Y, Jiang Y, Guo Y, Liu Y, et al. BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer. J Exp Clin Cancer Res. 2020;39:123 pubmed 出版商

Tian Y, Liu Q, Yu S, Chu Q, Chen Y, Wu K, et al. NRF2-Driven KEAP1 Transcription in Human Lung Cancer. Mol Cancer Res. 2020;: pubmed 出版商

Nordgren K, Wallace K. Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo. Cardiovasc Toxicol. 2020;: pubmed 出版商

Chen X, Qi J, Wu Q, Jiang H, Wang J, Chen W, et al. High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression. Acta Biochim Biophys Sin (Shanghai). 2020;52:506-516 pubmed 出版商

Zhou H, Yuan D, Gao W, Tian J, Sun H, Yu S, et al. Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia. IUBMB Life. 2020;72:1659-1679 pubmed 出版商

Jiang Z, Fu L, Xu Y, Hu X, Yang H, Zhang Y, et al. Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses. Sci Rep. 2020;10:6427 pubmed 出版商

Fan Y, Xing Y, Xiong L, Wang J. Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation. Chem Biol Interact. 2020;324:109086 pubmed 出版商

Wang S, Cheng H, Wang L, Zhao R, Guan D. Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes. Int J Mol Sci. 2020;21: pubmed 出版商

Wang Z, Cai L, Li H, Liang M, Zhang Y, Wu Q, et al. Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats. J Food Biochem. 2020;44:e13180 pubmed 出版商

Mo M, Li S, Dong Z, Li C, Sun Y, Li A, et al. S-allylmercaptocysteine ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation and oxidative stress via nuclear factor kappa B and Keap1/Nrf2 pathways. Int Immunopharmacol. 2020;81:106273 pubmed 出版商

Deng S, Essandoh K, Wang X, Li Y, Huang W, Chen J, et al. Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage. Redox Biol. 2020;32:101453 pubmed 出版商

Xu A, Yang Y, Shao Y, Wu M, Sun Y. Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation. Cell Commun Signal. 2020;18:9 pubmed 出版商

Xu Q, Shi W, Lv P, Meng W, Mao G, Gong C, et al. Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy. Cell Death Dis. 2020;11:6 pubmed 出版商

Lee D, Park J, Lee Y, Han J, Lee D, Kwon S, et al. SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. Autophagy. 2020;:1-25 pubmed 出版商

Li G, Li A, Chen X, Zhang L, Wang T, Wang X, et al. Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells. Biomed Pharmacother. 2020;121:109669 pubmed 出版商

Liu S, Xu S, Wei R, Cui Z, Wu X, Wei R, et al. Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation. Biomed Res Int. 2019;2019:5198138 pubmed 出版商

Zhang Y, Wang H, Zhang L, Yuan Y, Yu D. Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress. Int J Biol Macromol. 2019;: pubmed 出版商

Shi Y, Fan S, Wu M, Zuo Z, Li X, Jiang L, et al. YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression. Nat Commun. 2019;10:4892 pubmed 出版商

Xu B, Lang L, Lian S, Guo J, Wang J, Yang H, et al. Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure. Brain Sci. 2019;9: pubmed 出版商

Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, et al. Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal. Front Pharmacol. 2019;10:1030 pubmed 出版商

Zhang J, Cai W, Fan Z, Yang C, Wang W, Xiong M, et al. MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway. Atherosclerosis. 2019;290:9-18 pubmed 出版商

Xian P, Hei Y, Wang R, Wang T, Yang J, Li J, et al. Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice. Theranostics. 2019;9:5956-5975 pubmed 出版商

Deng Z, Lim J, Wang Q, Purtell K, Wu S, Palomo G, et al. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway. Autophagy. 2019;:1-15 pubmed 出版商

Tocmo R, Parkin K. S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2. Free Radic Biol Med. 2019;143:164-175 pubmed 出版商

Wu X, Chen X, Zhou M, Hu H, Zhang J, Wang X, et al. Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells. Chem Biol Interact. 2019;310:108741 pubmed 出版商

Bao F, Tao L, Zhang H. Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation. Cell Mol Neurobiol. 2019;: pubmed 出版商

Lignitto L, LeBoeuf S, Homer H, Jiang S, Askenazi M, Karakousi T, et al. Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1. Cell. 2019;: pubmed 出版商

Liang M, Li H, Wang Z, Cai L, Yang L. Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats. J Sci Food Agric. 2019;: pubmed 出版商

Yan X, Fu X, Jia Y, Ma X, Tao J, Yang T, et al. Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells. Oxid Med Cell Longev. 2019;2019:2654910 pubmed 出版商

Xu B, Lang L, Li S, Guo J, Wang J, Wang D, et al. Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure. Cells. 2019;8: pubmed 出版商

Betharia S, Rondόn Ortiz A, Brown D. Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells. Neurochem Res. 2019;: pubmed 出版商

Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, et al. Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents. Nat Commun. 2019;10:2538 pubmed 出版商

Li A, Shen T, Wang T, Zhou M, Wang B, Song J, et al. Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis. Free Radic Biol Med. 2019;141:21-33 pubmed 出版商

Peng D, Lu H, Zhu S, Zhou Z, Hu T, Chen Z, et al. NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells. Cancer Lett. 2019;458:46-55 pubmed 出版商

Sparaneo A, Fabrizio F, la Torre A, Graziano P, Di Maio M, Fontana A, et al. Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors. Int J Mol Sci. 2019;20: pubmed 出版商

Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, et al. MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1. Pharmacol Res. 2019;146:104276 pubmed 出版商

Kukoyi A, Fan X, Staitieh B, Hybertson B, Gao B, McCord J, et al. MiR-144 mediates Nrf2 inhibition and alveolar epithelial dysfunction in HIV-1 transgenic rats. Am J Physiol Cell Physiol. 2019;: pubmed 出版商

Yan J, Pang Y, Zhuang J, Lin H, Zhang Q, Han L, et al. Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo. ACS Chem Neurosci. 2019;: pubmed 出版商

Park J, Lee Y, Lee D, Bae S. Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity. Free Radic Biol Med. 2019;137:143-157 pubmed 出版商

Ast T, Meisel J, Patra S, Wang H, Grange R, Kim S, et al. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019;: pubmed 出版商

Jia Y, Peng Y, Zhao Y, Cheng X, Zhou Y, Chai C, et al. Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs. J Agric Food Chem. 2019;: pubmed 出版商

Zhang B, Wang G, He J, Yang Q, Li D, Li J, et al. Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner. J Neuroinflammation. 2019;16:92 pubmed 出版商

Wang Z, Liang M, Li H, Cai L, He H, Wu Q, et al. l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats. J Sci Food Agric. 2019;99:4849-4862 pubmed 出版商

Hu T, Schreiter F, Bagchi R, Tatman P, Hannink M, McKinsey T. HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression. J Biol Chem. 2019;294:8640-8652 pubmed 出版商

Qi Y, Li R, Xu L, Yin L, Xu Y, Han X, et al. Neuroprotective Effect of Dioscin on the Aging Brain. Molecules. 2019;24: pubmed 出版商

Yamada M, Iwata M, Warabi E, Oishi H, Lira V, Okutsu M. p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle. FASEB J. 2019;:fj201900133R pubmed 出版商

Park J, Lee D, Lee Y, Oh E, Bae K, Oh K, et al. Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity. Autophagy. 2019;:1-20 pubmed 出版商

Zhang B, Wu J, Cai Y, Luo M, Wang B, Gu Y. TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer. Acta Biochim Biophys Sin (Shanghai). 2019;51:375-385 pubmed 出版商

Wang P, Geng J, Gao J, Zhao H, Li J, Shi Y, et al. Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis. Nat Commun. 2019;10:755 pubmed 出版商

Wang H, Wei W, Lan X, Liu N, Li Y, Ma H, et al. Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway. ACS Chem Neurosci. 2019;10:2276-2286 pubmed 出版商

Zhou X, Zhu C, Wu Z, Guo X, Zou W. The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis. Oncogene. 2019;38:4028-4046 pubmed 出版商

Karras P, Riveiro Falkenbach E, Cañón E, Tejedo C, Calvo T, Martínez Herranz R, et al. p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors. Cancer Cell. 2019;35:46-63.e10 pubmed 出版商

Yang Q, Lin J, Zhang H, Liu Y, Kan M, Xiu Z, et al. Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments. J Mol Neurosci. 2019;67:62-71 pubmed 出版商

Qiao Y, Sun Y, Shen T, Zhang J, Zhou J, Li Y, et al. Diterpenoids from the Chinese liverwort Frullania hamatiloba and their Nrf2 inducing activities. Phytochemistry. 2019;158:77-85 pubmed 出版商

Ullah O, Li Z, Ali I, Xu L, Liu H, Shah S, et al. Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos. J Reprod Dev. 2019;65:73-81 pubmed 出版商

Beneduce E, Matte A, De Falco L, Mbiandjeu S, Chiabrando D, Tolosano E, et al. Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis. Am J Hematol. 2019;94:10-20 pubmed 出版商

Kanamoto M, Tsuchiya Y, Nakao Y, Suzuki T, Motohashi H, Yamamoto M, et al. Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding. PLoS ONE. 2018;13:e0203978 pubmed 出版商

Cai J, Pires K, Ferhat M, Chaurasia B, Buffolo M, Smalling R, et al. Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk. Cell Rep. 2018;25:1708-1717.e5 pubmed 出版商

Shin D, Kim E, Lee J, Roh J. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018;129:454-462 pubmed 出版商

Li Y, Fu S, Li E, Sun X, Xu H, Meng Y, et al. Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice. Phytother Res. 2018;32:2480-2486 pubmed 出版商

Li Y, Li G, Zhou M, Xiang L, Ren D, Lou H, et al. Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults. Bioorg Med Chem. 2018;26:5140-5150 pubmed 出版商

Eckhardt M, Zhang W, Gross A, Von Dollen J, Johnson J, Franks Skiba K, et al. Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network. Cancer Discov. 2018;8:1474-1489 pubmed 出版商

Cloer E, Siesser P, Cousins E, Goldfarb D, Mowrey D, Harrison J, et al. p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2. Mol Cell Biol. 2018;38: pubmed 出版商

Zhang X, Li X, Fang J, Hou X, Fang H, Guo F, et al. (2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating. J Cell Biochem. 2018;119:8981-8995 pubmed 出版商

Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, et al. Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro. Regul Toxicol Pharmacol. 2018;98:58-68 pubmed 出版商

Prestigiacomo V, Suter Dick L. Nrf2 protects stellate cells from Smad-dependent cell activation. PLoS ONE. 2018;13:e0201044 pubmed 出版商

Yamada T, Murata D, Adachi Y, Itoh K, Kameoka S, Igarashi A, et al. Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease. Cell Metab. 2018;28:588-604.e5 pubmed 出版商

Endo H, Owada S, Inagaki Y, Shida Y, Tatemichi M. Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells. Sci Rep. 2018;8:10122 pubmed 出版商

Yang B, Cheng H, Wang L, Fu J, Zhang G, Guan D, et al. Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes. Toxicol Appl Pharmacol. 2018;355:189-197 pubmed 出版商

Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina Y, et al. Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma. J Clin Invest. 2018;128:3341-3355 pubmed 出版商

Cai S, Hou N, Zhao G, Liu X, He Y, Liu H, et al. Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats. Front Pharmacol. 2018;9:540 pubmed 出版商

Liu J, Li W, Limbu M, Li Y, Wang Z, Cheng Z, et al. Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice. Front Pharmacol. 2018;9:555 pubmed 出版商

Adams O, Janser F, Dislich B, Berezowska S, Humbert M, Seiler C, et al. A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas. PLoS ONE. 2018;13:e0197610 pubmed 出版商

Li Y, Qian W, Wang D, Meng Y, Wang X, Chen Y, et al. Resveratrol relieves particulate matter (mean diameter < 2.5 ?m)-induced oxidative injury of lung cells through attenuation of autophagy deregulation. J Appl Toxicol. 2018;38:1251-1261 pubmed 出版商

Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y, et al. KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. Nature. 2018;557:585-589 pubmed 出版商

Li Y, Li G, Sun L, Li L, Liu Y, Kong D, et al. Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response. Oxid Med Cell Longev. 2018;2018:7616852 pubmed 出版商

Hu Q, Qin Y, Xiang J, Liu W, Xu W, Sun Q, et al. dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer. Cell Prolif. 2018;51:e12456 pubmed 出版商

Bi W, He C, Li X, Zhou L, Liu R, Zhang S, et al. Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway. Food Funct. 2018;9:2809-2819 pubmed 出版商

Zhang J, Jiao Q, Kong L, Yu J, Fang A, Li M, et al. Nrf2 and Keap1 abnormalities in esophageal squamous cell carcinoma and association with the effect of chemoradiotherapy. Thorac Cancer. 2018;9:726-735 pubmed 出版商

Zhou M, Zhang W, Li R, Guo C, Wei S, Tian X, et al. Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-?B, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells. Phytomedicine. 2018;42:152-163 pubmed 出版商

Liang M, Wang Z, Li H, Cai L, Pan J, He H, et al. l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway. Food Chem Toxicol. 2018;115:315-328 pubmed 出版商

Zhao L, Tao X, Qi Y, Xu L, Yin L, Peng J. Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress. Redox Biol. 2018;16:189-198 pubmed 出版商

Zhao D, Badur M, Luebeck J, Magaña J, Birmingham A, Sasik R, et al. Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis. Mol Cell. 2018;69:699-708.e7 pubmed 出版商

Jia Y, Lu H, Peng Y, Zhang B, Gong X, Su J, et al. Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. Int Immunopharmacol. 2018;56:105-112 pubmed 出版商

Lu M, Liu T, Jiao Q, Ji J, Tao M, Liu Y, et al. Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway. Eur J Med Chem. 2018;146:251-259 pubmed 出版商

Kageyama S, Saito T, Obata M, Koide R, Ichimura Y, Komatsu M. Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant. Mol Cell Biol. 2018;38: pubmed 出版商

Shen Z, Wang Y, Su Z, Kou R, Xie K, Song F. Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice. Chem Biol Interact. 2018;282:22-28 pubmed 出版商

Li S, Dai Q, Zhang S, Liu Y, Yu Q, Tan F, et al. Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway. Acta Pharmacol Sin. 2018;39:1294-1304 pubmed 出版商

Gong W, Chen Z, Zou Y, Zhang L, Huang J, Liu P, et al. CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys. Free Radic Biol Med. 2018;115:338-350 pubmed 出版商

An H, Harper J. Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy. Nat Cell Biol. 2018;20:135-143 pubmed 出版商

Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, et al. Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation. Toxicol Lett. 2018;284:37-45 pubmed 出版商

Lin E, Bayarsengee U, Wang C, Chiang Y, Cheng C. The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway. Environ Toxicol. 2018;33:72-82 pubmed 出版商

Zhou M, Li G, Sun B, Xu Y, Li A, Li Y, et al. Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells. Redox Biol. 2018;14:154-163 pubmed 出版商

Huang R, Li X, Yu Y, Ma L, Liu S, Zong X, et al. SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis. Oncotarget. 2017;8:94080-94090 pubmed 出版商

Ge W, Zhao K, Wang X, Li H, Yu M, He M, et al. iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding. Cancer Cell. 2017;32:561-573.e6 pubmed 出版商

Huang K, Gao X, Wei W. The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-?1 expressions in rat glomerular mesangial cells. Exp Cell Res. 2017;361:63-72 pubmed 出版商

Anzovino A, Chiang S, Brown B, Hawkins C, Richardson D, Huang M. Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3? Axis. Am J Pathol. 2017;187:2858-2875 pubmed 出版商

O Mealey G, Plafker K, Berry W, Janknecht R, Chan J, Plafker S. A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking. J Cell Sci. 2017;130:3467-3480 pubmed 出版商

Mildenberger J, Johansson I, Sergin I, Kjøbli E, Damas J, Razani B, et al. N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2. Autophagy. 2017;13:1664-1678 pubmed 出版商

Wu J, Tian Z, Sun Y, Lu C, Liu N, Gao Z, et al. Exogenous H2S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy. Cell Death Dis. 2017;8:e2992 pubmed 出版商

Akdemir B, Nakajima Y, Inazawa J, Inoue J. miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1. Mol Cancer Res. 2017;15:1570-1578 pubmed 出版商

Liu J, Li Y, Liu L, Wang Z, Shi C, Cheng Z, et al. Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes. Front Physiol. 2017;8:291 pubmed 出版商

Wang Q, Ma J, Lu Y, Zhang S, Huang J, Bei J, et al. CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells. Oncogene. 2017;36:5321-5330 pubmed 出版商

Arai A, Chano T, Ikebuchi K, Hama Y, Ochi Y, Tameno H, et al. p62/SQSTM1 levels predicts radiotherapy resistance in hypopharyngeal carcinomas. Am J Cancer Res. 2017;7:881-891 pubmed

Gong W, Li J, Chen Z, Huang J, Chen Q, Cai W, et al. Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys. Free Radic Biol Med. 2017;106:393-405 pubmed 出版商

Krall E, Wang B, Munoz D, Ilic N, Raghavan S, Niederst M, et al. KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. elife. 2017;6: pubmed 出版商

Fabrizio F, Costantini M, Copetti M, la Torre A, Sparaneo A, Fontana A, et al. Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma. Oncotarget. 2017;8:11187-11198 pubmed 出版商

Xiao L, Xu X, Zhang F, Wang M, Xu Y, Tang D, et al. The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1. Redox Biol. 2017;11:297-311 pubmed 出版商

Nlandu Khodo S, Dissard R, Hasler U, Schafer M, Pircher H, Jansen Durr P, et al. NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury. Sci Rep. 2016;6:38598 pubmed 出版商

O Mealey G, Berry W, Plafker S. Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission. Redox Biol. 2017;11:103-110 pubmed 出版商

Duleh S, Wang X, Komirenko A, Margeta M. Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies. Acta Neuropathol Commun. 2016;4:115 pubmed

Park J, Oh S, Lee D, Lee Y, Sung S, Ji H, et al. p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death. Free Radic Res. 2016;50:1408-1421 pubmed

Lee D, Han D, Nam K, Park J, Kim S, Lee M, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016;99:520-532 pubmed 出版商

Mulvaney K, Matson J, Siesser P, Tamir T, Goldfarb D, Jacobs T, et al. Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate. J Biol Chem. 2016;291:23719-23733 pubmed

Wang S, Chen Y, Kou R, Wang Y, Zeng T, Xie K, et al. Carbon disulfide activates p62-Nrf2-keap1 pathway in rat nerve tissues. Toxicology. 2016;368-369:19-27 pubmed 出版商

Gong W, Chen C, Xiong F, Yang Z, Wang Y, Huang J, et al. CKIP-1 ameliorates high glucose-induced expression of fibronectin and intercellular cell adhesion molecule-1 by activating the Nrf2/ARE pathway in glomerular mesangial cells. Biochem Pharmacol. 2016;116:140-52 pubmed 出版商

Zhao L, Xu L, Tao X, Han X, Yin L, Qi Y, et al. Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation. Molecules. 2016;21: pubmed 出版商

Tao X, Sun X, Xu L, Yin L, Han X, Qi Y, et al. Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats. Nutrients. 2016;8: pubmed 出版商

Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, et al. p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. Nat Commun. 2016;7:12030 pubmed 出版商

Sergin I, Bhattacharya S, Emanuel R, Esen E, Stokes C, Evans T, et al. Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis. Sci Signal. 2016;9:ra2 pubmed 出版商

Eino A, Kageyama S, Uemura T, Annoh H, Saito T, Narita I, et al. Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells. J Cell Sci. 2015;128:4453-61 pubmed 出版商

Park J, Kang D, Lee D, Bae S. PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1. Biochem Biophys Res Commun. 2015;466:499-504 pubmed 出版商

Park J, Kang D, Lee D, Bae S. Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity. Biochem Biophys Res Commun. 2015;466:131-7 pubmed 出版商

Probst B, McCauley L, Treviño I, Wigley W, Ferguson D. Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405. PLoS ONE. 2015;10:e0135257 pubmed 出版商

Park J, Kang D, Lee D, Bae S. Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation. Biochem Biophys Res Commun. 2015;465:542-7 pubmed 出版商

Park J, Kang D, Bae S. p62 prevents carbonyl cyanide m-chlorophenyl hydrazine (CCCP)-induced apoptotic cell death by activating Nrf2. Biochem Biophys Res Commun. 2015;464:1139-1144 pubmed 出版商

Awuh J, Haug M, Mildenberger J, Marstad A, Do C, Louet C, et al. Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages. Proc Natl Acad Sci U S A. 2015;112:E4272-80 pubmed 出版商

Bakkar N, Kousari A, Kovalik T, Li Y, Bowser R. RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1. Mol Cell Biol. 2015;35:2385-99 pubmed 出版商

Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, et al. Potent effects of dioscin against liver fibrosis. Sci Rep. 2015;5:9713 pubmed 出版商

Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, et al. Potent effects of dioscin against obesity in mice. Sci Rep. 2015;5:7973 pubmed 出版商

Tanji K, Odagiri S, Miki Y, Maruyama A, Nikaido Y, Mimura J, et al. p62 Deficiency Enhances α-Synuclein Pathology in Mice. Brain Pathol. 2015;25:552-64 pubmed 出版商

Huang K, Chen C, Hao J, Huang J, Wang S, Liu P, et al. Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells. Mol Cell Endocrinol. 2015;399:178-89 pubmed 出版商