产品简要
公司名称 :
武汉三鹰
产品类型 :
抗体
产品名称 :
TDP-43(C末端)
目录 :
12892-1-AP
规格 :
150UL
价格 :
299美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , 免疫组化-冰冻切片, 免疫组化基因敲除验证
更多信息或购买 :
文章摘录数: 62
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 人类; 图 1i
Zhang P, Fan B, Yang P, Temirov J, Messing J, Kim H, et al. Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 人类; 图 4a
  • 免疫组化-冰冻切片; 小鼠; 图 7a
  • 免疫印迹; 小鼠; 图 4a, 4c
Lee Y, Huang W, Lin J, Kao T, Lin H, Lee K, et al. Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology. J Biomed Sci. 2018;25:76 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 3a
Maziuk B, Apicco D, Cruz A, Jiang L, Ash P, da Rocha E, et al. RNA binding proteins co-localize with small tau inclusions in tauopathy. Acta Neuropathol Commun. 2018;6:71 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2e
Becker L, Huang B, Bieri G, Ma R, Knowles D, Jafar Nejad P, et al. Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice. Nature. 2017;544:367-371 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 1b
  • 免疫印迹; 小鼠; 图 1c
Leal Lasarte M, Franco J, Labrador Garrido A, Pozo D, Roodveldt C. Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia. FASEB J. 2017;31:2797-2816 pubmed 出版商
  • 免疫细胞化学; 人类; 图 6g
Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, et al. Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics. Mol Cell. 2017;65:1044-1055.e5 pubmed 出版商
  • 免疫印迹; 人类; 1:2500; 图 5a
Wobst H, Wesolowski S, Chadchankar J, Delsing L, Jacobsen S, Mukherjee J, et al. Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro. Front Mol Neurosci. 2017;10:46 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3s1
Celona B, Dollen J, Vatsavayai S, Kashima R, Johnson J, Tang A, et al. Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. elife. 2017;6: pubmed 出版商
  • 免疫组化基因敲除验证; 小鼠; 1:150; 图 1c
Laclair K, Donde A, Ling J, Jeong Y, Chhabra R, Martin L, et al. Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathol. 2016;132:859-873 pubmed
  • 免疫印迹; 人类; 图 9f
Suzuki H, Matsuoka M. The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death. J Biol Chem. 2016;291:21448-21460 pubmed
  • 免疫印迹; 小鼠; 1:1000; 图 1b
Shiihashi G, Ito D, Yagi T, Nihei Y, Ebine T, Suzuki N. Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice. Brain. 2016;139:2380-94 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500; 图 3
  • 免疫组化; 小鼠; 1:500; 图 6
  • 免疫印迹; 小鼠; 1:1000; 图 1
Rodriguez Ortiz C, Flores J, Valenzuela J, Rodriguez G, Zumkehr J, Tran D, et al. The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress. Am J Pathol. 2016;186:1623-34 pubmed 出版商
Laclair K, Zhou Q, Michaelsen M, Wefers B, Brill M, Janjić A, et al. Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS. Acta Neuropathol. 2020;140:121-142 pubmed 出版商
Pourhaghighi R, Ash P, Phanse S, Goebels F, Hu L, Chen S, et al. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst. 2020;10:333-350.e14 pubmed 出版商
Strah N, Romano G, Introna C, Klima R, Marzullo M, Ciapponi L, et al. TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles. BMC Biol. 2020;18:34 pubmed 出版商
Khosravi B, LaClair K, Riemenschneider H, Zhou Q, Frottin F, Mareljic N, et al. Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD. EMBO J. 2020;39:e102811 pubmed 出版商
Tang F, Zhao L, Zhao Y, Sun D, Zhu X, Mei L, et al. Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons. Cell Death Differ. 2020;: pubmed 出版商
Lanznaster D, Bourgeais J, Bruno C, Hergesheimer R, Thepault R, Vourc H P, et al. TDP-43-Mediated Toxicity in HEK293T Cells: A Fast and Reproducible Protocol To Be Employed in the Search of New Therapeutic Options against Amyotrophic Lateral Sclerosis. Cells. 2019;9: pubmed 出版商
Yuva Aydemir Y, Almeida S, Krishnan G, Gendron T, Gao F. Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD. Nat Commun. 2019;10:5466 pubmed 出版商
Suzuki H, Shibagaki Y, Hattori S, Matsuoka M. C9-ALS/FTD-linked proline-arginine dipeptide repeat protein associates with paraspeckle components and increases paraspeckle formation. Cell Death Dis. 2019;10:746 pubmed 出版商
Deng Z, Lim J, Wang Q, Purtell K, Wu S, Palomo G, et al. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway. Autophagy. 2019;:1-15 pubmed 出版商
Donde A, Sun M, Ling J, Braunstein K, Pang B, Wen X, et al. Splicing repression is a major function of TDP-43 in motor neurons. Acta Neuropathol. 2019;: pubmed 出版商
Sugai A, Kato T, Koyama A, Koike Y, Konno T, Ishihara T, et al. Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation. Neurobiol Dis. 2019;130:104534 pubmed 出版商
Tsunemi T, Perez Rosello T, Ishiguro Y, Yoroisaka A, Jeon S, Hamada K, et al. Increased lysosomal exocytosis induced by lysosomal Ca2+ channel agonists protects human dopaminergic neurons from α-synuclein toxicity. J Neurosci. 2019;: pubmed 出版商
Choi S, López González R, Krishnan G, Phillips H, Li A, Seeley W, et al. C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo. Nat Neurosci. 2019;22:851-862 pubmed 出版商
Wang B, Maxwell B, Joo J, Gwon Y, Messing J, Mishra A, et al. ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97. Mol Cell. 2019;74:742-757.e8 pubmed 出版商
Coudert L, Nonaka T, Bernard E, Hasegawa M, Schaeffer L, Leblanc P. Phosphorylated and aggregated TDP-43 with seeding properties are induced upon mutant Huntingtin (mHtt) polyglutamine expression in human cellular models. Cell Mol Life Sci. 2019;76:2615-2632 pubmed 出版商
Gasset Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, et al. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. 2019;102:339-357.e7 pubmed 出版商
Mann J, Gleixner A, Mauna J, Gomes E, DeChellis Marks M, Needham P, et al. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron. 2019;102:321-338.e8 pubmed 出版商
Zhang Y, Guo L, Gonzales P, Gendron T, Wu Y, Jansen West K, et al. Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Science. 2019;363: pubmed 出版商
Masaki K, Sonobe Y, Ghadge G, Pytel P, Roos R. TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection. PLoS Pathog. 2019;15:e1007574 pubmed 出版商
Fourier A, Escal J, Bernard E, Lachman I, Perret Liaudet A, Leblanc P, et al. Development of an automated capillary nano-immunoassay-Simple Western assay-to quantify total TDP43 protein in human platelet samples. Anal Bioanal Chem. 2019;411:267-275 pubmed 出版商
Ash P, Dhawan U, Boudeau S, Lei S, Carlomagno Y, Knobel M, et al. Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology. Toxicol Sci. 2019;167:105-115 pubmed 出版商
Jeon G, Shim Y, Lee D, Kim J, Kang M, Ahn S, et al. Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations. Mol Neurobiol. 2019;56:2007-2021 pubmed 出版商
Vogler T, Wheeler J, Nguyen E, Hughes M, Britson K, Lester E, et al. TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. Nature. 2018;563:508-513 pubmed 出版商
Liu C, Leng B, Li Y, Jiang H, Duan W, Guo Y, et al. Diallyl Trisulfide Protects Motor Neurons from the Neurotoxic Protein TDP-43 via Activating Lysosomal Degradation and the Antioxidant Response. Neurochem Res. 2018;43:2304-2312 pubmed 出版商
Suzuki H, Shibagaki Y, Hattori S, Matsuoka M. The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis. Cell Death Dis. 2018;9:975 pubmed 出版商
Cicardi M, Cristofani R, Rusmini P, Meroni M, Ferrari V, Vezzoli G, et al. Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells. Sci Rep. 2018;8:12390 pubmed 出版商
Clemen C, Winter L, Strucksberg K, Berwanger C, Türk M, Kornblum C, et al. The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?. Biochem Biophys Res Commun. 2018;503:2770-2777 pubmed 出版商
Kasu Y, Alemu S, Lamari A, Loew N, Brower C. The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology. Mol Cell Biol. 2018;38: pubmed 出版商
Salvatori I, Ferri A, Scaricamazza S, Giovannelli I, Serrano A, Rossi S, et al. Differential toxicity of TAR DNA-binding protein 43 isoforms depends on their submitochondrial localization in neuronal cells. J Neurochem. 2018;146:585-597 pubmed 出版商
Wang K, Qu X, Liu S, Yang X, Bie F, Wang Y, et al. Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma. J Cancer Res Clin Oncol. 2018;144:1509-1521 pubmed 出版商
Maucuer A, Desforges B, Joshi V, Boca M, Kretov D, Hamon L, et al. Microtubules as platforms for probing liquid-liquid phase separation in cells - application to RNA-binding proteins. J Cell Sci. 2018;131: pubmed 出版商
Bennett C, Dastidar S, Ling S, Malik B, Ashe T, Wadhwa M, et al. Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients. Acta Neuropathol. 2018;136:425-443 pubmed 出版商
Mackenzie I, Nicholson A, Sarkar M, Messing J, Purice M, Pottier C, et al. TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 2017;95:808-816.e9 pubmed 出版商
Prudencio M, Gonzales P, Cook C, Gendron T, Daughrity L, Song Y, et al. Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients. Hum Mol Genet. 2017;26:3421-3431 pubmed 出版商
Osuru H, Pramoonjago P, Abhyankar M, Swanson E, Roker L, Cathro H, et al. Immunolocalization of TAR DNA-binding protein of 43?kDa (TDP-43) in mouse seminiferous epithelium. Mol Reprod Dev. 2017;84:675-685 pubmed 出版商
Zhuang J, Wen X, Zhang Y, Shan Q, Zhang Z, Zheng G, et al. TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2',4,4'-tetrabromodiphenyl ether (BDE-47)-treated mice. Brain Behav Immun. 2017;65:99-110 pubmed 出版商
Wobst H, Delsing L, Brandon N, Moss S. Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant. PLoS ONE. 2017;12:e0177181 pubmed 出版商
Ash P, Stanford E, Al Abdulatif A, Ramirez Cardenas A, Ballance H, Boudeau S, et al. Dioxins and related environmental contaminants increase TDP-43 levels. Mol Neurodegener. 2017;12:35 pubmed 出版商
Schludi M, Becker L, Garrett L, Gendron T, Zhou Q, Schreiber F, et al. Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss. Acta Neuropathol. 2017;134:241-254 pubmed 出版商
Ditsworth D, Maldonado M, McAlonis Downes M, Sun S, Seelman A, Drenner K, et al. Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis. Acta Neuropathol. 2017;133:907-922 pubmed 出版商
Jeong Y, Ling J, Lin S, Donde A, Braunstein K, Majounie E, et al. Tdp-43 cryptic exons are highly variable between cell types. Mol Neurodegener. 2017;12:13 pubmed 出版商
Manghera M, Ferguson Parry J, Douville R. TDP-43 regulates endogenous retrovirus-K viral protein accumulation. Neurobiol Dis. 2016;94:226-36 pubmed 出版商
Wang G, Yang H, Yan S, Wang C, Liu X, Zhao B, et al. Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain. Mol Neurodegener. 2015;10:42 pubmed 出版商
Chou C, Alexeeva O, Yamada S, Pribadi A, Zhang Y, Mo B, et al. PABPN1 suppresses TDP-43 toxicity in ALS disease models. Hum Mol Genet. 2015;24:5154-73 pubmed 出版商
Goossens J, Vanmechelen E, Trojanowski J, Lee V, Van Broeckhoven C, van der Zee J, et al. TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies. Acta Neuropathol Commun. 2015;3:15 pubmed 出版商
Paré B, Touzel Deschênes L, Lamontagne R, Lamarre M, Scott F, Khuong H, et al. Early detection of structural abnormalities and cytoplasmic accumulation of TDP-43 in tissue-engineered skins derived from ALS patients. Acta Neuropathol Commun. 2015;3:5 pubmed 出版商
Raitano S, Ordovas L, De Muynck L, Guo W, Espuny Camacho I, Geraerts M, et al. Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia. Stem Cell Reports. 2015;4:16-24 pubmed 出版商
Suzuki H, Matsuoka M. Overexpression of nuclear FUS induces neuronal cell death. Neuroscience. 2015;287:113-24 pubmed 出版商
Han H, Wei W, Duan W, Guo Y, Li Y, Wang J, et al. Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). In Vitro Cell Dev Biol Anim. 2015;51:249-63 pubmed 出版商
Suzuki H, Shibagaki Y, Hattori S, Matsuoka M. Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs. Hum Mol Genet. 2015;24:1513-27 pubmed 出版商
图像
图像 1 :
武汉三鹰 12892-1-AP 图像 1
The TDP-43 (C-terminal) antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TDP-43 (C-terminal). This antibody recognizes human,mouse,rat antigen. The TDP-43 (C-terminal) antibody has been validated for the following applications: IF, IHC, IP, WB, ELISA analysis.
产品信息
目录号 :
12892-1-AP
AntigenName :
TDP-43(C末端)
Package :
150UL
价格 :
299美元
Exsists20ul :
20ul trial size available
FullName :
焦油DNA结合蛋白
免疫原 :
重组蛋白
物种 :
drosophila, human, monkey, mouse, rat, zebrafish
宿主 :
IsConjugated :
未共轭
AntigenSpecies :
人类
应用 :
免疫印迹, 免疫沉淀, 免疫组化, IF, chIP, 酶联免疫吸附测定
Clonlity :
多克隆
抗体亚型 :
IgG
同义词 :
ALS10, 焦油DNA结合蛋白, 焦油DNA结合蛋白43, TARDBP, TAR DNA结合蛋白43, TDP43
PrimaryOrSecondary :
Primary
抗体缓冲液 :
PBS含0.1%叠氮化钠和50% 甘油pH值7.3
GenBank登录号 :
BC001487
类别 :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Disease Related;Metabolism;Neurology;
PurifyMethod :
抗原亲和纯化
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:100;免疫组化1:1000;免疫沉淀1:1000;免疫印迹1:800;
更多信息或购买 :
公司信息
武汉三鹰
武汉市洪山区关山二路关东科技园7-4#,402室
Service@ptglab.com
http://www.ptgcn.com
4006 900 926, 027-87531629 / 027-87531627
公司总部: 美国
Proteintech Group致力于开发针对所有人类蛋白的抗体,我们将这项计划命名为人类抗体组计划。Proteintech Group在科研领域享有良好声誉, 迄今已生产出针对10,000种不同人类蛋白的10,000种抗体。同时,Proteintech Group也提供多种客户订单服务:克隆,表达,多肽合成,多抗及单抗生产,以满足您的不同需求。

Proteintech Group的创建者都是资深科研人员,我们非常理解科学家们对工作尽善尽美的追求,我们也以同样的标准来要求我们的产品。作为科研领域的成员之一,我们要做每一项科研工作背后的默默支持者,为科学家们提供质量优良,价格合理的产品和服务。

我们承诺为您提供高品质的抗体及相关产品,让您不再担忧试剂的品质,让您能够倾注您全部的创造力,才华和精力于研究当中。我们坚信只有您成功了,我们才会成功。