产品简要
公司名称 :
武汉三鹰
产品类型 :
抗体
产品名称 :
GCLM
目录 :
14241-1-AP
规格 :
150UL
价格 :
299美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪
更多信息或购买 :
文章摘录数: 43
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 1j
Wei Y, Lu M, Mei M, Wang H, Han Z, Chen M, et al. Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection. Nat Commun. 2020;11:941 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3c
Lv W, Deng B, Duan W, Li Y, Liu Y, Li Z, et al. Schwann Cell Plasticity is Regulated by a Weakened Intrinsic Antioxidant Defense System in Acute Peripheral Nerve Injury. Neuroscience. 2018;382:1-13 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
Tian Y, Wu K, Liu Q, Han N, Zhang L, Chu Q, et al. Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer. J Hematol Oncol. 2016;9:83 pubmed 出版商
Chen X, Qi J, Wu Q, Jiang H, Wang J, Chen W, et al. High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression. Acta Biochim Biophys Sin (Shanghai). 2020;52:506-516 pubmed 出版商
Hou X, Xu H, Chen W, Zhang N, Zhao Z, Fang X, et al. Neuroprotective effect of dimethyl fumarate on cognitive impairment induced by ischemic stroke. Ann Transl Med. 2020;8:375 pubmed 出版商
Qi J, Chen X, Wu Q, Wang J, Zhang H, Mao A, et al. Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression. Oxid Med Cell Longev. 2020;2020:3985089 pubmed 出版商
Bi W, Shao S, Li Z, Ruan Y, Luan S, Dong Z, et al. FSHR ablation induces depression-like behaviors. Acta Pharmacol Sin. 2020;41:1033-1040 pubmed 出版商
Wang S, Cheng H, Wang L, Zhao R, Guan D. Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes. Int J Mol Sci. 2020;21: pubmed 出版商
Hang H, Wang L, Ren S, Song A, Wu G. Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia. Curr Med Sci. 2020;40:55-62 pubmed 出版商
Wang Z, Cai L, Li H, Liang M, Zhang Y, Wu Q, et al. Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats. J Food Biochem. 2020;44:e13180 pubmed 出版商
Yang W, Chen X, Wang S, Hu H, Cheng X, Xu L, et al. 4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease. J Nat Prod. 2020;83:1217-1228 pubmed 出版商
Lee J, Ishihara K, Notomi S, Efstathiou N, Ueta T, Maidana D, et al. Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells. Biochem Biophys Res Commun. 2019;: pubmed 出版商
Shu G, Qiu Y, Hao J, Fu Q, Deng X. γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways. Food Funct. 2019;10:6858-6872 pubmed 出版商
Zheng J, Tian X, Zhang W, Zheng P, Huang F, Ding G, et al. Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation. Mar Drugs. 2019;17: pubmed 出版商
Tang X, Fu X, Liu Y, Yu D, Cai S, Yang C. Blockade of glutathione metabolism in IDH1-mutated glioma. Mol Cancer Ther. 2019;: pubmed 出版商
Lu Q, Tan S, Gu W, Li F, Hua W, Zhang S, et al. Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway. J Ethnopharmacol. 2019;243:112089 pubmed 出版商
Wu X, Chen X, Zhou M, Hu H, Zhang J, Wang X, et al. Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells. Chem Biol Interact. 2019;310:108741 pubmed 出版商
Lu M, Zhao J, Liu Y, Liu T, Tao M, You Q, et al. CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation. Redox Biol. 2019;26:101266 pubmed 出版商
Betharia S, Rondόn Ortiz A, Brown D. Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells. Neurochem Res. 2019;: pubmed 出版商
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, et al. Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents. Nat Commun. 2019;10:2538 pubmed 出版商
Zhang J, Hong Y, Cao W, Yin S, Shi H, Ying W. SIRT2, ERK and Nrf2 Mediate NAD+ Treatment-Induced Increase in the Antioxidant Capacity of PC12 Cells Under Basal Conditions. Front Mol Neurosci. 2019;12:108 pubmed 出版商
Yan J, Pang Y, Zhuang J, Lin H, Zhang Q, Han L, et al. Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo. ACS Chem Neurosci. 2019;: pubmed 出版商
Wang Z, Liang M, Li H, Cai L, He H, Wu Q, et al. l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats. J Sci Food Agric. 2019;99:4849-4862 pubmed 出版商
Jobbagy S, Vitturi D, Salvatore S, Turell L, Pires M, Kansanen E, et al. Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis. Redox Biol. 2019;21:101050 pubmed 出版商
Peng L, Zhao Y, Li Y, Zhou Y, Li L, Lei S, et al. Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury. J Mol Med (Berl). 2019;97:189-199 pubmed 出版商
Yang W, Li Y, Gao H, Wu X, Wang X, Wang X, et al. Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice. J Ethnopharmacol. 2018;227:166-175 pubmed 出版商
Richardson B, Jain A, Potteti H, Lazzara P, David B, Tamatam C, et al. Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors. J Med Chem. 2018;61:8029-8047 pubmed 出版商
Yuan X, Yang C, Wang X, Zhang L, Gao X, Shi Z. Progesterone maintains the status of granulosa cells and slows follicle development partly through PGRMC1. J Cell Physiol. 2018;234:709-720 pubmed 出版商
Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, et al. Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro. Regul Toxicol Pharmacol. 2018;98:58-68 pubmed 出版商
Li Y, Li G, Sun L, Li L, Liu Y, Kong D, et al. Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response. Oxid Med Cell Longev. 2018;2018:7616852 pubmed 出版商
Wei X, Mo X, An F, Ji X, Lu Y. 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone, a potent Nrf2/ARE pathway inhibitor, reverses drug resistance by decreasing glutathione synthesis and drug efflux in BEL-7402/5-FU cells. Food Chem Toxicol. 2018;119:252-259 pubmed 出版商
Liang M, Wang Z, Li H, Cai L, Pan J, He H, et al. l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway. Food Chem Toxicol. 2018;115:315-328 pubmed 出版商
Tang J, Vissers M, Anderson R, Sreebhavan S, Bozonet S, Scheepens A, et al. Bioavailable Blueberry-Derived Phenolic Acids at Physiological Concentrations Enhance Nrf2-Regulated Antioxidant Responses in Human Vascular Endothelial Cells. Mol Nutr Food Res. 2018;62: pubmed 出版商
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, et al. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Biomed Pharmacother. 2018;97:481-488 pubmed 出版商
Tomiyama R, Takakura K, Takatou S, Le T, Nishiuchi T, Nakamura Y, et al. 3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester induce preconditioning ER stress and autophagy in SH-SY5Y cells. J Cell Physiol. 2018;233:1671-1684 pubmed 出版商
Nie H, Xue X, Liu G, Guan G, Liu H, Sun L, et al. Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase. Free Radic Res. 2016;50:1200-1213 pubmed
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, et al. Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation. Environ Toxicol Pharmacol. 2016;45:193-201 pubmed 出版商
Cao W, Hong Y, Chen H, Wu F, Wei X, Ying W. SIRT2 mediates NADH-induced increases in Nrf2, GCL, and glutathione by modulating Akt phosphorylation in PC12 cells. FEBS Lett. 2016;590:2241-55 pubmed 出版商
Zheng Z, Xu H, Suo S, Xu X, Ni M, Gu L, et al. The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer. Sci Rep. 2016;6:26093 pubmed 出版商
Yu G, Deng A, Tang W, Ma J, Yuan C, Ma J. Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity. Neurochem Int. 2016;96:113-20 pubmed 出版商
Yuan X, Fan Y, Yang C, Gao X, Zhang L, Hu Y, et al. Progesterone amplifies oxidative stress signal and promotes NO production via H2O2 in mouse kidney arterial endothelial cells. J Steroid Biochem Mol Biol. 2016;155:104-11 pubmed 出版商
Snyder N, Golin Bisello F, Gao Y, Blair I, Freeman B, Wendell S. 15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways. Chem Biol Interact. 2015;234:144-53 pubmed 出版商
Ma Q, Zhao J, Cao W, Liu J, Cui S. Estradiol decreases taurine level by reducing cysteine sulfinic acid decarboxylase via the estrogen receptor-α in female mice liver. Am J Physiol Gastrointest Liver Physiol. 2015;308:G277-86 pubmed 出版商
图像
图像 1 :
武汉三鹰 14241-1-AP 图像 1
The GCLM antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GCLM. This antibody recognizes human,mouse,rat antigen. The GCLM antibody has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA analysis.
产品信息
目录号 :
14241-1-AP
AntigenName :
GCLM
Package :
150UL
价格 :
299美元
Exsists20ul :
20ul trial size available
FullName :
glutamate-cysteine ligase, modifier subunit
免疫原 :
重组蛋白
物种 :
人类, 小鼠, 大鼠
宿主 :
IsConjugated :
未共轭
AntigenSpecies :
人类
应用 :
免疫印迹, 免疫沉淀, 免疫组化, IF, FC, 酶联免疫吸附测定
Clonlity :
多克隆
抗体亚型 :
IgG
同义词 :
Gamma ECS regulatory subunit, GCLM, GCS light chain, GLCLR
PrimaryOrSecondary :
Primary
抗体缓冲液 :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBank登录号 :
BC041809
类别 :
结合蛋白;代谢;
PurifyMethod :
抗原亲和纯化
NewAb :
False
IsSellable :
True
AppTiter :
FC 1:0;IF 1:50;免疫组化1:200;免疫沉淀1:1000;免疫印迹1:1000;
更多信息或购买 :
公司信息
武汉三鹰
武汉市洪山区关山二路关东科技园7-4#,402室
Service@ptglab.com
http://www.ptgcn.com
4006 900 926, 027-87531629 / 027-87531627
公司总部: 美国
Proteintech Group致力于开发针对所有人类蛋白的抗体,我们将这项计划命名为人类抗体组计划。Proteintech Group在科研领域享有良好声誉, 迄今已生产出针对10,000种不同人类蛋白的10,000种抗体。同时,Proteintech Group也提供多种客户订单服务:克隆,表达,多肽合成,多抗及单抗生产,以满足您的不同需求。

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我们承诺为您提供高品质的抗体及相关产品,让您不再担忧试剂的品质,让您能够倾注您全部的创造力,才华和精力于研究当中。我们坚信只有您成功了,我们才会成功。