产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗胱氨酸-天冬氨酸蛋白酶3抗体
目录 :
11024-50
规格 :
50微克
价格 :
273美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 犬, 鸡, 牛
更多信息或购买 :
QED Bioscience 产品网页
图像
图像 1 :
QED Bioscience 11024-50 图像 1
Detection of caspase-3 in Jurkat cell lysate (lane 2), staurosporine-treated Jurkat cell lysate (lane 3), MCF-7 cell lysate (negative control, lane 4), HeLa cell lysate (lane 5), rat spleen lysate (lane 6), mouse spleen lysate (lane 7).
图像 2 :
QED Bioscience 11024-50 图像 2
Detection of caspase-3 in human spleen.
产品信息
目录号 :
11024-50
产品名称 :
抗胱氨酸-天冬氨酸蛋白酶3抗体
NAME+SKU :
抗胱氨酸-天冬氨酸蛋白酶3抗体(11024-50)
产品_TYPE :
抗体
描述 :
抗胱氨酸-天冬氨酸蛋白酶3抗体兔多克隆抗体
SPECIFICITY SHORT :
胱氨酸-天冬氨酸蛋白酶3抗体
物种活性 :
Human, mouse, rat, rabbit, chicken, guinea pig, hamster, monkey, sheep, bovine, canine, porcine, yeast
靶标名 :
胱氨酸-天冬氨酸蛋白酶3
UniProt数据库 :
P42574
LOCATION :
细胞质
蛋白名 :
胱氨酸-天冬氨酸蛋白酶3
基因名称 :
CASP3
克隆性 :
多克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
50微克
标价规格1 :
273美元
DISTIRBUTOR价格 :
191.1
SKU号规格1 :
11024-50
应用 :
Human, mouse, rat, rabbit, chicken, guinea pig, hamster, monkey, sheep, bovine, canine, porcine, yeast
应用INSTRUCTIONS :
Immunoblotting: use at 1-5ug/ml. A band of ~36kDa is detected. Immunohistochemistry: use at 10ug/ml These are recommended concentrations. Endusers should determine optimal concentrations for their applications.
宿主 :
兔
格式 :
纯化
纯化 :
经免疫亲和层析纯化
免疫原 :
重组全长人类胱氨酸-天冬氨酸蛋白酶3
研究领域 :
凋亡
配方 :
PBS, 50% 甘油, 0.09% 叠氮化钠
缓冲液 :
磷酸盐缓冲液
缓冲液抗MICROBIAL :
0.09% 叠氮化钠
缓冲液CRYOPRESERVATIVE :
50% 甘油
靶标背景 :
Caspases are cysteine proteases that cleave after certain aspartate residues and have been identified as mediators of apoptosis. Caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.
FUNCTION :
Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed:7596430). At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond (PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (PubMed:7596430). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486). {PubMed:21357690, PubMed:23152800, PubMed:23845944, PubMed:30878284, PubMed:33725486, PubMed:7596430, PubMed:7774019, PubMed:8696339}.
STORAGE空调 :
This product is stable for at least one (1) year at -20C. Avoid multiple freeze-thaw cycles.
图像Name_1 :
qed-bioscience-anti-caspase-3-antibody-11024-1.jpg
应用1 :
免疫印迹
图像Name_2 :
qed-bioscience-anti-caspase-3-antibody-11024-2.jpg
应用2 :
免疫组化
更多信息或购买 :
QED Bioscience 产品网页
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
公司总部: 美国