抗体

抗Hsp90甲抗体

11112

100微克

378美元

单克隆

小鼠

未共轭

2G5.G3

人类, 小鼠, 大鼠

抗Hsp90甲抗体

抗Hsp90甲抗体(11112)

抗体

抗Hsp90甲小鼠单克隆抗体

Hsp90甲

人类, 小鼠, 大鼠

Hsp90甲

P07900

Nucleus , Cytoplasm , Melanosome , Cell membrane , Mitochondrion

热休克蛋白HSP 90甲

EC 3.6.4.10, Heat shock 86 kDa, HSP 86, HSP86, Lipopolysaccharide-associated protein 2, LAP-2, LPS-associated protein 2, Renal carcinoma antigen NY-REN-38

HSP90AA1

NP_001017963.2

单克隆

液体

Lot Specific

100微克

378美元

264.6

11112

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫沉淀

Immunoblotting: use at 0.5-1ug/ml. A band of ~90 kDa is detected. ELISA Immunohistochemistry/ Immuno- cytochemistry Imunoprecipitation User should determine optimal concentrations for their application. Positive control: HeLa cell lysate.

小鼠

纯化

Purified by Protein G affinity chromatography.

IgG1

2G5.G3

Host Species: Mouse

加热休克&压力蛋白

PBS, pH值7.4

磷酸盐缓冲液

pH值7.4

Hsp90 is an abundantly and ubiquitously expressed heat shock protein found in all eukaryotic cells. It exists in two principal forms, alpha and beta, which share 85% sequence homology. Both forms are expressed in the cytosol. Hsp90alpha exists primarily as a homodimer while Hsp90beta exists mainly as a monomer. Hsp90 plays a role in folding, assembly, maturation, and stabilization of specific proteins as a key component of a chaperone complex. Most of the Hsp90-regulated proteins that have been identified are involved in cell signaling; kinases, v-Src, Wee1, c-Raf, and p53 are some examples. When bound to ATP, Hsp90 interacts with co- chaperones Cdc37, p23, and various immunophilin-like proteins to form complexes that stabilize and protect target proteins from proteasomal degradation.

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate rPubMed:11274138, PubMed:11276205, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:20628368, PubMed:24613385, PubMed:25609812, PubMed:27353360, PubMed:29127155, PubMed:25973397, PubMed:26991466, PubMed:27295069}.

Dilute in PBS or medium which is identical to that used in the assay system.

This antibody is stable for at least one (1) year at -20C. Avoid repeated freezing and thawing.

This antibody recognizes human, mouse, and rat Hsp90alpha. Other species have not been tested. It does not cross-react with Hsp90beta in ELISA.