产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗CCR5(NT)抗体
目录 :
1112
规格 :
100微克
价格 :
455美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
更多信息或购买 :
QED Bioscience 产品网页
图像
图像 1 :
QED Bioscience 1112 图像 1
Immunohistochemistry of CCR5 in human lymph node tissue with CCR5 antibody at 20 ug/mL.
图像 2 :
QED Bioscience 1112 图像 2
Immunohistochemistry of CCR5 in human lymph node tissue with CCR5 antibody at 2.5 ug/ml.
产品信息
目录号 :
1112
产品名称 :
抗CCR5(NT)抗体
NAME+SKU :
抗CCR5(NT)抗体(1112)
产品_TYPE :
抗体
描述 :
抗CCR5(NT)兔多克隆抗体
SPECIFICITY SHORT :
CCR5(NT)
物种活性 :
人类
靶标名 :
CCR5(NT)
UniProt数据库 :
P51681
LOCATION :
Cell membrane , Multi-pass membrane protein
蛋白名 :
C-趋化因子C受体类型5
别称 :
C-C CKR-5, CC-CKR-5, CCR-5, CCR5, CHEMR13, HIV-1 fusion coreceptor, CD antigen CD195
基因名称 :
CCR5
登录号 :
NP_000570
克隆性 :
多克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
100微克
标价规格1 :
455美元
DISTIRBUTOR价格 :
318.5
SKU号规格1 :
1112
应用 :
免疫印迹
应用INSTRUCTIONS :
Immunoblotting: use at 1:1,000-1:2,000 dilution. Positive control: Whole cell lysate from THP-1 cells.
宿主 :
兔
格式 :
纯化
纯化 :
经免疫亲和层析纯化
免疫原 :
Peptide corresponding to aa 6-20 of human CCR5.
研究领域 :
传染病学
配方 :
PBS, pH值7.4
缓冲液 :
磷酸盐缓冲液
缓冲液pH值 :
pH值7.4
靶标背景 :
Human immunodeficiency virus (HIV) and related viruses require coreceptors in addition to CD4 to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, Bonzo, GPR1, and V28, have been identified as HIV coreceptors. Among them, CCR5 is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains. CCR5 is required for infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-1alpha, and MIP-1beta are the ligands for CCR5 and prevent infection by macrophage-tropic HIV-1. CCR5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV binding sites. Messenger RNA for CCR5 is expressed in lymphoid cells and tissues.
FUNCTION :
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed:30713770). {PubMed:10383387, PubMed:11323418, PubMed:30713770, PubMed:8639485, PubMed:8663314, PubMed:8699119}.; (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1. {PubMed:10383387, PubMed:21763489, PubMed:8649511, PubMed:8649512, PubMed:9632396}.
稀释INSTRUCTIONS :
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE空调 :
This antibody is stable for at least one (1) year at -20C. Avoid multiple freeze-thaw cycles.
特异性 :
This antibody recognizes human CCR5 (40 kD).
图像Name_1 :
qed-bioscience-anti-ccr5-nt-antibody-1112-1.jpg
应用1 :
免疫印迹
图像Name_2 :
qed-bioscience-anti-ccr5-nt-antibody-1112-2.jpg
应用2 :
免疫组化
图像Name_3 :
qed-bioscience-anti-ccr5-nt-antibody-1112-3.gif
应用3 :
免疫组化
图像Name_4 :
qed-bioscience-anti-ccr5-nt-antibody-1112-4.gif
图像Caption_4 :
Immunofluorescence of CCR5 in human lymph node tissue with CCR5 antibody at 20 ug/mL. Green: CCR5 Antibody (1112) . Blue: DAPI staining
应用4 :
IF
更多信息或购买 :
QED Bioscience 产品网页
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
公司总部: 美国